List of Articles Peganum harmala

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  1 - Study effect of methanolic extract of Peganum Harmala and Harmine on Kidney tissue damage of diabetes mellitus in male Wistar rats
  Forough Kajbaf Shahrbanoo Oryan Ramesh Ahmadi Akram Eidi
  Introduction: The dangerous side effects of diabetes are diabetic nephropathy, which has a relatively high prevalence in diabetic patients and causes renal failure. Investigating the process of destruction and the mechanisms that prevent it, in order to reduce the tissu More

  Introduction: The dangerous side effects of diabetes are diabetic nephropathy, which has a relatively high prevalence in diabetic patients and causes renal failure. Investigating the process of destruction and the mechanisms that prevent it, in order to reduce the tissue damage, especially with the treatment of plants, can be a significant issue. Material and methods: In this research, Espand with scientific name of Peganum harmala, a plant of the Zygophyllaceae family and its effective substance called harmine in diabetes-induced renal injury, were studied on 80 male Wistar rats in experimental and diabetic groups. Rats were treated with methanolic extract of seeds and leaves of Peganum Harmala and Harmine. After tissue passage and fixation, Microscopic slides were prepared and studied. In tissue studies, four factors of epithelial changes, tubular destruction, leukocyte inflammation and capillary obstruction were detected in the kidneys. Results: The diabetic rat group received harmine and the diabetic rats receiving the extract of the seed were less damaged, while in the diabetic rats recieveing the leaf extract these lesions was higher and it was interesting to note that there was no difference in the experimental groups with the positive control group. Conclusion: According to the tissue results in our study, seed extract and harmine have the ability to prevent tissue damage caused by diabetes, which can be attributed to the harmine alkaloid in the seed.     Manuscript profile
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  2 - In vitro assessment of antimicrobial effect of methanolic extract of Peganum harmala against some important foodborne bacterial pathogens
  طیبه zeinali محمد Mohsenzadeh رویا Rezaeian-Doloei رویا Nabipour
  Foodborne bacterial pathogens play an important role in food infections/intoxications in human population. With ever increasing the number of antibiotic-resistant bacterial strains, there is an attempt to use the antimicrobial properties of herbs. Peganum harmala is a m More

  Foodborne bacterial pathogens play an important role in food infections/intoxications in human population. With ever increasing the number of antibiotic-resistant bacterial strains, there is an attempt to use the antimicrobial properties of herbs. Peganum harmala is a medicinal plant of Iraniantraditional medicine which was used as an antiseptic in the past. Amongthe foodborne bacterial pathogens, Escherichia coli O157:H7, Salmonella Typhimurium and Listeria monocytogenes are considered as the most important and hazardous pathogens. The aim of this study was to evaluate the antibacterial effect of methanolic extract of Peganum harmala against these bacteria in vitro. The minimum inhibitory concentration (MIC) and minimum bactericidal concentrations (MBC) of methanolic extract of Peganum harmala was determined against three foodborne bacterial pathogens by micro-dilution method in Muller-Hinton broth. According to the results, MIC for E. coli O157:H7 and S. Typhimurium was 1.56 mg/ml. In the case of L. monocytogenes, it was estimated at 0.78 mg/ml. Moreover, results revealed that MBC for these organisms was similar to MIC concentrations. Regarding the results, Peganum harmala can be used as an ingredient in the formula of the disinfectants applied in the food systems.  Manuscript profile
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  3 - Antibacterial activities of the ultrasound assisted extracts of Laurus nobilis, Peganum harmala and rosemary
  M. Ghorbanpour H. Jahedi
  The present study was aimed to investigate the antibacterial activities of the Laurus nobilis,Peganumharmala and rosemary extracts against Staphylococcus aureus and Escherichia coli. Thus, the ultrasonic extracts were performed using the aqueous, ethanol, hydro-alcoholi More

  The present study was aimed to investigate the antibacterial activities of the Laurus nobilis,Peganumharmala and rosemary extracts against Staphylococcus aureus and Escherichia coli. Thus, the ultrasonic extracts were performed using the aqueous, ethanol, hydro-alcoholic or chloroform phases. The microdilution technique was used to evaluate the antibacterial activities which was finally reported as the MIC and MBC values. All the extracts showed the antibacterial activities against the bacteria at the concentration of 6.25%. However, the metalonic extract exert a maximum antibacterial activity. The extract of three plants revealed the same antibacterial activity against E. coli, but the ethanoloic extract from P. harmala showed a maximum antibacterial activity against S. aureus at the concentration of 6.25%. Results of the current study showed the similar antibacterial activities of the extracts against E. coli; meanwhile, the maximum antibacterial effect on S. aureus was observed by applying alcohol or water as a solvent. In general, this paper proposed that ultrasound assisted extraction was quick and cost effective approach to extract the plants. In addition, ethanolic solvent was found as the best selection among the aqueous, hydro-alcoholic or chloroform solvents. Manuscript profile
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  4 - Antibacterial survey of different extracts of Peganum harmala L. different parts in North east of Golestan province (Inche Borun)
  معصومه Mazandarani E.A Ghaemi فاطمه Ghaffari
  Peganum harmala L. belongs to Zigophyllaceae family is one of the most important medicine plants with wild distribution in stepic and semi stepic of Golestan province. In this research, after phenology ethnopharmacological data obtained from turkman rural people. Differ More

  Peganum harmala L. belongs to Zigophyllaceae family is one of the most important medicine plants with wild distribution in stepic and semi stepic of Golestan province. In this research, after phenology ethnopharmacological data obtained from turkman rural people. Different parts of plant were collected in May to late of September 2008 in dry stepic region of North east of Golestan province (Inche Borun). Aqueous, infusion and ethanolic extract were obtained by percolation method and their antibacterial effect was evaluated by disc diffusion and well methods. Inhibition zone after 24h incubation of 37 and their antibacterial activity were assessed by Pearson chi-square (P<0.05). Ethnopharmacological data in this research showed, it has been used by the Turkmen rural healers in North east of Golestan province as strong anti air infection, sedative, anti bacterial and skin inflammation to treatment fungal, gastro intestinal infection and dysmenorrhea. Ethanol extracts of root and seeds had the most efficacy against tested bacteria, especially in well method (P<0.001), another extracts had no any antibacterial effect. 78.8% of gram positive and negative bacteria (Bacillus licheniformis, Staphylococcus epidermisis, Staphylococcus aureus, Micrococcus loteus, Salmonella typhi, Shigella dysentria) were the most sensitive bacteria against ethanol extract, but gram negative bacteria such as Pseudomonas aeroginosa and Proteus loteus were the most resistant bacteria (P<0.001). Rural people were interested to take seed and smok for air disinfection, sedative and calming, can be a good candid for chemical analysis of antibacterial activity in animal and clinical models for formulation and production of natural antibacterial drug. Manuscript profile
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  5 - Effects of Artemisia sieberi extract on growth and nutrients uptake of Peganum harmala
  Asma Ricki Maryshany Mahdieh Ebrahimi Ebrahim Shirmohammadi
  10.30495/ijpp.2018.540890
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  6 - Determination of Seizure Threshold due to Intrapritoneal Injection of Harmaline in NMRI Mice
  غلامحسن واعظی مهسا ترابی عبدالحسین شیروی
  Harmaline is one of the alkaloids that exist in different plant like Peganum harmala. This alkaloid has stimulative effect on realasing serotonin and katkol -amins in different parts of the brain.Also this alkaloid has hallucinogenic effect. one of the most important ph More

  Harmaline is one of the alkaloids that exist in different plant like Peganum harmala. This alkaloid has stimulative effect on realasing serotonin and katkol -amins in different parts of the brain.Also this alkaloid has hallucinogenic effect. one of the most important pharmacological effects of Harmaline is the inhibitory effect on Monoamine oxidase enzyme.Also Harmaline with attachment to Inverse agonist locus GABA-A receptors produced a wide range of antagonistic effects against benzodiazepins and interference of benzodiazepine receptors in produce seizure and tremor has show.This research has done to estimate seizure threshold due to intrapritoneal injection of Harmaline in comparison with seizure threshold pentylenetetrazole (PTZ) of male NMRI mice.In this research the positive control receive of amount 45mg/kg,ip of PTZ and the other groups were injected with 5,10,20 mg/kg,ip of Harmaline.After above injections, seizure symptom has been estimated.As result of this research indicate the seizure threshold in positive group (PTZ) is amount 45mg/kg and seizure threshold of Harmaline is amount 5 mg/kg.In conclusion can reveal that Harmaline with attachment to Inverse agonist locus GABA-A receptors produced a wide range of antagonistic effects against benzodiazepins and has show that gabaergic system and serotonin neurotransmitters are involved in seizure activity due to Harmaline.While in seizure due to PTZ,interfere picrotoxine locus of GABA receptor and benzodiazepine locus has partial role on its effects.The result of this research has been shown that Harmaline reduce seizure threshold dose dependent significantly. Manuscript profile