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      • Open Access Article

        1 - Comparative study of sedation and pre-anesthetic effects of polar, semi polar and non-polar fractions of vinca minor extract in comparison with midazolam in rat
        A. Rezaei, E. Issabeagloo, مهرداد Pashazadeh, .
        Periwinkle is a plant known as a Vinca minor in Persian. This plant contain bitter substancecalled Vincine, Tannin, Pectin, Carotene, vincamine Alkaloids, Vinci nine, Catarin, and a kindof Saponin and large amount of Vinine Alkaloids and Pubcine. All parts of this plant More
        Periwinkle is a plant known as a Vinca minor in Persian. This plant contain bitter substancecalled Vincine, Tannin, Pectin, Carotene, vincamine Alkaloids, Vinci nine, Catarin, and a kindof Saponin and large amount of Vinine Alkaloids and Pubcine. All parts of this plant can beused; especially the leaves that can be picked in any season and seared by heat. The purpose ofthis study is evaluating sedation and pre-anesthetic effects of polar fractions, semi polar andnon-polar of Vinca minor plant in comparison with midazolam found in rats. 60 Wistar rat headin different groups is applied in these tests. Three polar, semi-polar, and non-polar fractions and0.04 mg/kg dose of midazolam and dimethyl sulfoxide (DMSO) with equal volume aretransfused into peritoneum as a drug, half an hour before experiment. In a test the sedation andpre-anesthetic induction time and sleeping time effects are surveyed by seconds and recorded bychronometer. Findings show that in medical team the mentioned doses of extract meaningfulboth in infused dream by ketamine and increase in life time (p<0.01). According to sedationand pre-anesthetic effects of this plant, studies indicate that polar fraction of Vinca minor with100 mg/kg dose has sedation, pre-anesthetic effects. Manuscript profile
      • Open Access Article

        2 - Comparative study on geometric and histopathologic effects of polar, semi polar and non-polar fractions Artemisia absinthium extract in rat
        Rezaei, A., Mohajeri, D., Ahmadizadeh, Ch., Jalilzadeh, M. .
        Recovery of Scars is a treatment challenge in some diseases and chronic disorders. For this reason, new compounds are used for rapid recovery of Scars and conglutination. It is expected that Artemisia absinthium as a galenical and herbal drug, has rapid recovery effects More
        Recovery of Scars is a treatment challenge in some diseases and chronic disorders. For this reason, new compounds are used for rapid recovery of Scars and conglutination. It is expected that Artemisia absinthium as a galenical and herbal drug, has rapid recovery effects in scars and sores because has anti- inflammation effects, activation of fibroblast cells and also antihyaluronidase effects cause the rapid recovery of sores. In this study, effects of Artemisia absinthium on recovery of sores as polar, semi polar and non-polar extractions of it are investigated on the rat as a second recovery. After anesthesia, with use of biopsy punch, Created circular sores with full thickness on the 70 female rats and recovery process were investigated in 5 groups. Drug administration and sores measures performed with analyzing of digital Scans, once a day for 21 days. For microscopic observations, gathered Samplings form this tissue in the 0, 3, 7, 14, 21 days, and microscopic symbols are ranged as edema factors and swelling reactions, hyperemia and bleeding, fibroblast, of Coverage tissue, torsion of sores and maturation of granular tissue. After histopathology and Calculation of recovery of sores scale for each drug, the finding results analyzed with SPSS software 17 versions. On the basis of geometric findings of recovery period, observed that semi polar extract of Artemisia absinthium has maximum Contraction of sores and control group has the least contraction of sores. Also, based on the histopathology results, total recovery in this group is better than other groups. In the second and third week. Recovered tissue has better organization than the other groups.  Manuscript profile
      • Open Access Article

        3 - Study on sedative effects of different fractions of Hop (Humulus lupulus L.) extract compared with diazepam in rats
        رامین Shishehgar علی Rezaie ایلیاد Iesa beiglou محمد Jalilzadeh Hedayati CH Ahmadizadeh سلما Asl Faeghi A.R Ebadi
        Humulus lupulus is a medicinal plant which in Farsi is called "razak". The purpose of this research is, studying the sedative effects of polar, semi polar and non polar fractions extracted from Hop (Humulus lupulus. L) in comparison with diazepam in the animal model of More
        Humulus lupulus is a medicinal plant which in Farsi is called "razak". The purpose of this research is, studying the sedative effects of polar, semi polar and non polar fractions extracted from Hop (Humulus lupulus. L) in comparison with diazepam in the animal model of Rat. For conducting this research polar, semi polar and non polar fractions extracted from Hop based on the polarity of solvent. Then study continued with the injection of obtained extracts and other medicines to different groups of Wistar breed of rats. First group was injected with 100mg/kg of Polar fraction extract the second group, with 100mg/kg of Semipolar extract, the third group, with 100 mg/kg of non-polar extract of Humulus lupulus the fourth group with 2 mg/kg of Diazepam the fifth group with the same volume of DMSO used as solvent of injectable medicines an the sixth group was the control group and did not receive any drug. The method of injection was Intra peritoneal (IP) form. Statistical diagrams and results showed a significant decreasing of anesthetic induction time and increasing of sleeping time of Ketamin induced anesthesia, after IP injection of the Polar fraction extract of Humulus lupulus. The results obtained showed that the polar-fraction extract of Humulus lupulus has more sufficient sedative effects than diazepam and other under studied groups. Manuscript profile
      • Open Access Article

        4 - Comparative study of antibacterial effects of polar, semi-polar, and nonpolar fractions of Rosa canina extract against some pathogenic bacteria
        sanaz tahmasebi changiz ahmadizadeh
        Due to the increasing demand for food worldwide, people inadvertently or deliberately, through the production, supply, import, and export of spoiled and contaminated food, cause instantaneous diseases, short-term, long-term, and even many deaths. Rose canina is one of t More
        Due to the increasing demand for food worldwide, people inadvertently or deliberately, through the production, supply, import, and export of spoiled and contaminated food, cause instantaneous diseases, short-term, long-term, and even many deaths. Rose canina is one of the most valuable medicinal plants that most people use in their lands to treat some diseases. The purpose of this study was to investigate the antimicrobial effects of polar, semi-polar, and non-polar fractions of Rosa canina L. extract on Pseudomonas aeruginosa, Staphylococcus aureus, Listeria monocytogenes, and E. coli. In this study, Rosa canina was used. First, methanolic, chloroform and hexane extracts of R.canina were extracted, and the effects of different concentrations of these extracts were investigated. All experiments were carried out using the well-diffusion method and MIC and MBC determination on standard strains of Intended bacterias. The chloroform extract of the Rosa canina prevented at a concentration of 6.25 μg / ml has an inhibitory effect on Gram-positive bacteria in Listeria monocytogenes. While the impact on gram-negative bacteria of Pseudomonas aeruginosa and Escherichia coli is required for high concentrations of chloroform extract. Methanolic extract of Rosa canina at a concentration of 25 μg / ml has an inhibitory and killing effect on both gram-positive bacteria and gram-negative bacteria, and the chloroform extract of this plant has a most inhibitory effect on Listeria monocytogenes. In general, it can be concluded that the extract of Rosa canina has an antibacterial effect. Manuscript profile