جنین موش

Open Access Article

1 - TThe Biological Effects of Aqueous Extract of Ephedra major on the Development of Balb/C Mouse Embryos 7Th to 10Th Days of Pregnancy
S. Saffari P. Torabzadeh S.M. Mousavi Dohooii

Aqueous extract of Ephedra major used as a drug for blood pleasure, sleep disorder and lose weight. But it is effects on the body especially during pregnancy have not been reviewed. Therefore in study The Biological effects of aqueous extract of Ephedra major on the dev More

Aqueous extract of Ephedra major used as a drug for blood pleasure, sleep disorder and lose weight. But it is effects on the body especially during pregnancy have not been reviewed. Therefore in study The Biological effects of aqueous extract of Ephedra major on the development Balb.C mouse embryos 7Th to 10Th days of pregnancy. In this study 50 female Balb.C mice were randomly divided into 6 groups including: control group (non- injection), sham group (injection of saline) and 4 experimental groups. Lethal dose of LD50 was determined in condition of 3086 mg.kg.bw in vivo and selected dose for injection 300 mg.kg.bw. Injection was done on the seventh to tenth days by enema. Then the mouse were sacrificed on day 15 of pregnancy.For security of results above experiences was repeated three times. Data was checked with SPSS21 software and Duncan test subjest to (P Manuscript profile

Open Access Article

2 - The Effects of Diazinon on the Development of Balb/C Mice Embryos in 3th to 6th Days of Pregnancy
S. Rastgar Gharahshiran P. Torabzadeh S. Saffari

Diazinon is one of agricultural pesticides and organophosphate pesticide, because the chemical structure and the effects have been devastating on nervous, respiratory and digestive systems in recent years there have been studied. But it is effects on the embryo especial More

Diazinon is one of agricultural pesticides and organophosphate pesticide, because the chemical structure and the effects have been devastating on nervous, respiratory and digestive systems in recent years there have been studied. But it is effects on the embryo especially during pregnancy have not been reviewed. Therefore in study The Biological effects of pesticide diazinon on the development of Balb/C Mouse Embryos Third to Sixth Days of pregnancy. In this study 90 female Balb/C mice were randomly divided into 6 equal groups acontrol group (non- injection) and sham (injection of saline) and 4 experimental groups. The lethal dose LD50 was determined in condition of 11.09 ml/kg.bw in vivo and selected dose for injection 0.4 ml/kg.bw. Injection was done on mouse embryos 3Th to 6Th days of pregnancy by enema. Then the mouse were sacrificed on day 15 of pregnancy.For security of results above experiences was repeated three times. Data was checked with SPSS17 software and Duncan test subjest to (P Manuscript profile

Open Access Article

3 - The Effect of Embryonic Cartilaginous Tissue Extract on Differentiation of Mesenchymal Stem Cells to Osteoblasts
مرضیه رمضانی رمضان خان بابایی ویدا حجتی

Allstem cells are originated from both embryonic stem cells and adult stem cells. The most important adult stemcellsaremesenchymal stem cells. Mesenchymal stem cellsare pluripotentandnon-hematopoietic cellswithahighdifferentiation potential.There arein thebone marrowand More

Allstem cells are originated from both embryonic stem cells and adult stem cells. The most important adult stemcellsaremesenchymal stem cells. Mesenchymal stem cellsare pluripotentandnon-hematopoietic cellswithahighdifferentiation potential.There arein thebone marrowand otherskeletal tissues.Mesenchymalstem cellsderivedfrombone marroware capabledifferentiationto osteoblast, osteocyte,adipocyte, chondrocyte, tendonsand muscle cells underin vivoandin vitro.In vitro osteoblastic differentiation needs to a variety of factors, which creates condition similar to bone tissue microenvironment. In this study, the effects of embryonic cartilaginous tissue extract was studied to differentiation of bone marrow mesenchymal stem cell into osteoblast. Mesenchymal stem cells were isolated from mice bone marrow and cultured in flasks containing DMEM-F12, 100 andmu;g/ml streptomycin, 100 U/ml penicillin and 10% FBS.Mesenchymal stem cellswerepurifiedbyseveral passages, then cellswere affectedby 15day mouse cartilaginous tissue extraction. After21 days ofculture, Alizarin Red staining was usedfor the detection ofosteoblasticcells.Aftereffect of extraction, spindle-shaped mesenchymal stem cellschange theirshapeAndmany appendages was observedincells. Alizarin Red staining has shown osteoblasticdifferentiation ofmesenchymal stem cells.Also osteoblastic differentiation of mesenchymal stem cells has confirmed morphogenic and osteogenic factors at cartilaginous tissue extracts of 15-day mouse embryo. Theresults express of osteoblastic differentiation of mesenchymal stem cells.Therefore, it is used in vitro models of osteoblast differentiation and genetic diseases of bone. Manuscript profile

Open Access Article

4 - The Teratogenic Effects Pesticide of Chlorpyrifos on the Development of BALB/c Mouse Embryos 3Th to 6Th Days of Pregnancy
S. Rastgar Gharahshiran P. Torabzadeh S. Saffari

Chlorpyrifos is one of organophosphate insecticides and had studied in recent years because it has many complications devastating on skin, nervous, respiratory and digestive systems, but its effects on the embryo especially during pregnancy has not been reviewed. Theref More

Chlorpyrifos is one of organophosphate insecticides and had studied in recent years because it has many complications devastating on skin, nervous, respiratory and digestive systems, but its effects on the embryo especially during pregnancy has not been reviewed. Therefore, in study the teratogenic effects pesticide of Chlorpyrifos on the development of BALB/c mouse embryos 3rd to 6thd of pregnancy. In this study, 50 female BALB/c mouse were randomly divided into 6 equal groups a control group (non-injection: 5 mice) and witness (injection of saline: 5 mice) and 4 experimental groups (each group: 10 mice). A lethal dose LD50 was determined in condition of 25.32 ml/kg.bw in vivo and selected dose for injection 0.4 ml/kg.bw. Injection was done on the 3rd to 6th d of pregnancy days by enema. Then the mouse was sacrificed on day 15 of pregnancy. For security of results above experiences was repeated 2 times. Data were checked with SPSS 17 software by percentage. After a comparative study at this dose has been observed a significant increase, extrahepatic, exencephaly, syndactyly, having a defect in dynamic organs (legs and hands), extensive bleeding in whole body and exophthalmia were compared with control and witness groups.According to the findings, negative effects of Chlorpyrifos use as pesticides in agricultural products. On the mouse embryos, it is recommended to protect the environment and human health, especially pregnant women use of non-chemical methods to control pests. Manuscript profile

Open Access Article

5 - The Teratogenic Effects Pesticide of Diazinon On the development of Balb/C Mouse Embryos 3Th to 6Th Days Of Pregnancy
safoora saffari Parvin Torabzadeh Saba Rastgar Gharahshiran

Introduction:Diazinon is one of agricultural pesticides and organophosphate pesticide, Because the chemical structure and the effects have been devastating on nervous, respiratory and digestive systems in recent years there have been studied. But It is effects on the em More

Introduction:Diazinon is one of agricultural pesticides and organophosphate pesticide, Because the chemical structure and the effects have been devastating on nervous, respiratory and digestive systems in recent years there have been studied. But It is effects on the embryo especially during pregnancy has not been reviewed.Therefore in study the teratogenic effects pesticide of Diazinon on the development of Balb/C mouse embryos 3Th to 6Th days of pregnancy.Material and Method:In this study 50 female Balb/C mice were randomly divided into 6 equal groups acontrol group(non-injection:5mice) and witess(injection of saline:5mice) and 4 experimental groups(each group: 10 mice).A lethaldose LD50 was determined in condition of 11.09 ml/kg.bw in vivo and selected dose for injection 0.4 ml/kg.bw.Injection was done on the 3Th to 6Th days of pregnancy by enema Then the mouse were sacrificed on day 15 of pregnancy.For security of results above experiences was repeated three times.Data was checked with SPSS17 software and Duncan test subjest to (P Manuscript profile

Open Access Article

6 - The Biological Effects Pesticide of Chlorpyrifos On the development of Balb/C Mouse Embryos Third to Sixth Days Of Pregnancy
safoora saffari Parvin Torabzadeh Saba Rastgar gharahshiran

Introduction: Chlorpyrifos is one of organophosphate Insecticides and had studied in recent years because it has many complications devastating on skin, nervous, respiratory and digestive systems. But It is effects on the embryo especially during pregnancy has not been More

Introduction: Chlorpyrifos is one of organophosphate Insecticides and had studied in recent years because it has many complications devastating on skin, nervous, respiratory and digestive systems. But It is effects on the embryo especially during pregnancy has not been reviewed, . Therefore in study The Biological effects pesticide of Chlorpyrifos on the development of Balb/C mouse embryos Third to Sixth days of pregnancy.Material and Method: In this study 90 female Balb/C mouse were randomly divided into 6 equal groups acontrol group (non- injection) and witess (injection of saline) and 4 experimental groups. A lethaldose LD50 was determined in condition of 25/32 ml/kg.bw in vivo and selected dose for injection 0/4 ml/kg.bw. Injection was done on the Third to Sixth days of pregnancy days by enema. Then the mouse were sacrificed on day 15 of pregnancy.For security of results above experiences was repeated three times. Data was checked with SPSS17 software with ANOVA and Duncan test subjest to (P Manuscript profile

Open Access Article

7 - Effects of Lavandula officinalis aqueous extract on fertility and embryo Balb/C mouse
fatemeh soheili parvin Torabzadeh safoora saffari

Introduction: In addition to the sedative properties of Lavandula officinalis aqueous extract, it has antimicrobial properties. However, its effect on fertility has not been reviewed yet. Therefore in this study the effect of Lavandula officinalis aqueous extract on fer More

Introduction: In addition to the sedative properties of Lavandula officinalis aqueous extract, it has antimicrobial properties. However, its effect on fertility has not been reviewed yet. Therefore in this study the effect of Lavandula officinalis aqueous extract on fertility and embryo Balb/C mouse was investigated.Material and Method: After preparation of aqueous extract, experiments was on 65 mice with selected doses: 6 (group1:15mice), 12 (group2:15mice), 18 (group3:15mice) g/kg.bw. Interperitoneally injections were done for 12 days. Results were compared with the control group (non-injection) and sham (injection of normal saline). For reliability of above results, experiences were repeated 3 times. Data was checked with SPSS 20.0 software and Duncan post test and ANOVA subject to (P Manuscript profile

Open Access Article

8 - The teratogenic effects of aqueous extract of Ephedra major on Balb/C mouse embryos third to sixth days of pregnancy
safoora saffari parvin Torabzadeh Ali Karimi

Introduction: Ephedra major plant in traditional medicine is used loss weight, blood pleasure treatment, common cold and muscular weakness. But effects on the body especially during pregnancy has not been reviewed. Therefore in study the teratogenic effects of aqueous e More

Introduction: Ephedra major plant in traditional medicine is used loss weight, blood pleasure treatment, common cold and muscular weakness. But effects on the body especially during pregnancy has not been reviewed. Therefore in study the teratogenic effects of aqueous extract of Ephedra major on Balb/C mouse embryos third to sixth days of pregnancy has been reviewed. Materials and methods: In this study 50 female Balb/C mice were randomly divided into 6 equal groups a control group (non-injection: 5 mice) and witess (injection of Physiology serum: 5 mice) and 4 experimental groups (each of 10 mice). A lethaldose LD50 was determined in condition of 3086 mg/kg.bw in vivo and selected dose for injection 500, 300 mg/kg.bw. Injection was done on the third to sixth days by enema and mice were sacrificed on fifteenth day of pregnancy. ANOVA statistical method was used and SPSS21 was used for diagramming software and to compare groups of Duncan test was used with significant condition P Manuscript profile

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