Xylazine is preanesthetic drug that have nausea and vomiting effects. This study was done inorder to assessment of the effects of dexamethasone, metoclopramide and the combination ofdexamethasone - metoclopramide administrations in prophylaxis of nausea and vomiting aft More
Xylazine is preanesthetic drug that have nausea and vomiting effects. This study was done inorder to assessment of the effects of dexamethasone, metoclopramide and the combination ofdexamethasone - metoclopramide administrations in prophylaxis of nausea and vomiting afterxylazine administration in dogs.15 mixed breed dogs with average weight 18.9±5 Kg were randomly selected in 3 groupsincluding intravenous (I.V) dexamethasone 1mg/kg , I.V metoclopramide 0.5mg/kg and combination of dexamethasone - metoclopramide (0.5 -1 mg/kg). For induction of anesthesia inall groups, initially I.V diazepam (0.2 mg/kg) then I.V xylazine ( 2 mg/kg) and I.V morphine (2mg/kg) were administrated and dexamethasone, metoclopramide and combination ofdexamethasone-metoclopramide were injected and dogs were underwent the laparotomytechnique. Anesthetic and recovery times, also nausea and vomiting effects at 30 min, 2, 4, 8and 24 h after anesthesia were recorded and results were analyzed by ANOVA and (P < 0.05)were considered significant.Duration of anesthesia at dexamethasone group were 48.2±2.8 min, metoclopramide group51.7±2.3 min and in dexamethasone-metoclopramide group 45.7±2.3 min, respectively.Significant difference was not seen at duration of anesthesia between three groups (P> 0.05)none was seen nausea and vomiting.Single or co-administration of dexamethasone and metoclopramide prevents nausea andvomiting in operation and recovery period.
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Background: Postoperative nausea and vomiting is caused by various factors and based on studies comparing the effects of various drugs in the prevention of postoperative nausea and vomiting.
Purpose: To compare the effectiveness of intravenous Ondansetron and Granisetr More
Background: Postoperative nausea and vomiting is caused by various factors and based on studies comparing the effects of various drugs in the prevention of postoperative nausea and vomiting.
Purpose: To compare the effectiveness of intravenous Ondansetron and Granisetron in the prevention of nausea and vomiting after cesarean section in spinal anesthesia procedures.
Method: We randomly assigned the women to cesarean surgery under spinal anesthesia in a 22 Bahman Hospital Islamic Azad University of Mashhad, and patients were divided into two groups of each 84 person,
Group I, intravenously ondansetron 4 mg and Group II, Granisetron 1 mg intravenously before anesthesia received, and questionnaire data on nausea and vomiting during the first hour after anesthesia records, we collected and analyzed.
Results: In our study 84 cases in the ondansetron group, 21 patients (25%) were had nausea and in Granistron group, 7 patients (8.3%) were had nausea. (P-value=0.004) The incidence of vomiting in the ondansetron group, 7 of 84 patients (8.3%) and vomiting was no reported in Granisetron group. (P-value=0.014)
Our findings suggest that 1mg Granisetron intravenously before spinal anesthesia is more effective than 4mg Ondansetron intravenously in the prevention of nausea and vomiting after cesarean section.
Discussion: Our findings support the effectiveness of Granisetron than Ondansetron. And recommended further studies to evaluate the effect of drug combination compared with either drug alone for the prevention of postoperative nausea and vomiting is performed in the future.
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BACKGROUND: Antiemetics currently in use are not totally effective.Serotonin receptor antagonists are a new class of antiemeticsthat have shown promise for treatment of nausea andvomiting in many situations. This study evaluates the efficacy of the Serotonin receptor an More
BACKGROUND: Antiemetics currently in use are not totally effective.Serotonin receptor antagonists are a new class of antiemeticsthat have shown promise for treatment of nausea andvomiting in many situations. This study evaluates the efficacy of the Serotonin receptor antagonist, ondansetron,for the prevention of postoperative nausea and vomiting.
METHODS: This randomized, double-blind study compared the efficacy of an intravenous dose of ondansetron 4 mg with metoclopramide 10 mg for the prevention of postoperative nausea and vomiting (PONV) in patients undergoing general anesthesia for openabdominal surgery. A total of 126 patients (63 ondansetron, 63 metoclopramide), ASA status I–II, aged 18–65yr,were included and received study medication 30 minutes after the induction of anaesthesia and a standardized anesthetic technique and intraoperative analgesia were used in all patients. The proportion of patients experiencing emesis or nausea and the duration of nausea and the number of emetic episodes, were recorded during the 24-h period after surgery.
RESULTS: During the overall observation period (0-24 h), significantly more patients who received ondansetron had no emetic episodes (87.3%) than those who received metoclopramide (73%, P = 0.044). A higher proportion of patients receiving ondansetron (71.4%) did not experience nausea (metoclopramide 63.5%, P=0.342).
CONCLUSIONS: Ondansetron was superior to metoclopramide for preventionof vomiting in the first 24h after surgury and the total number of emetic episodes was reduced significantly compared with metoclopramide, but no significant differenceswere observed between ondansetron and metoclopramide for nauseacontrol or treatment failure.
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