Comparison of intravenous Ondansetron and Granisetron in prevention of Post Cesarean section operation Nausea and Vomiting in 22Bahman Hospital of Mashhad Islamic Azad university
Subject Areas : علوم پزشکی
Hamed Beyzai
1
()
yasamanhozhabr hozhabrosadat
2
()
Vahid Maghferati
3
()
Mozhgan Raisi
4
()
Keywords: Ondansetron, Granisetron, Nausea, Vomiting,
Abstract :
Background: Postoperative nausea and vomiting is caused by various factors and based on studies comparing the effects of various drugs in the prevention of postoperative nausea and vomiting. Purpose: To compare the effectiveness of intravenous Ondansetron and Granisetron in the prevention of nausea and vomiting after cesarean section in spinal anesthesia procedures. Method: We randomly assigned the women to cesarean surgery under spinal anesthesia in a 22 Bahman Hospital Islamic Azad University of Mashhad, and patients were divided into two groups of each 84 person, Group I, intravenously ondansetron 4 mg and Group II, Granisetron 1 mg intravenously before anesthesia received, and questionnaire data on nausea and vomiting during the first hour after anesthesia records, we collected and analyzed. Results: In our study 84 cases in the ondansetron group, 21 patients (25%) were had nausea and in Granistron group, 7 patients (8.3%) were had nausea. (P-value=0.004) The incidence of vomiting in the ondansetron group, 7 of 84 patients (8.3%) and vomiting was no reported in Granisetron group. (P-value=0.014) Our findings suggest that 1mg Granisetron intravenously before spinal anesthesia is more effective than 4mg Ondansetron intravenously in the prevention of nausea and vomiting after cesarean section. Discussion: Our findings support the effectiveness of Granisetron than Ondansetron. And recommended further studies to evaluate the effect of drug combination compared with either drug alone for the prevention of postoperative nausea and vomiting is performed in the future.
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