مقایسه اثر اندانسترون و گرانیسترون وریدی در پیشگیری از تهوع و استفراغ بعد از عمل جراحی سزارین در بیمارستان 22 بهمن دانشگاه آزاد اسلامی مشهد
محورهای موضوعی : علوم پزشکیحامد بیضائی 1 , یاسمن هژبرالساداتی 2 , وحید مغفرتی 3 , مژگان رئیسی 4
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کلید واژه: اندانسترون, گرانیسترون, تهوع, استفراغ,
چکیده مقاله :
زمینه: تهوع و استفراغ بعداز عمل جراحی، توسط عوامل مختلفی ایجاد میشود و مطالعات بر اساس مقایسه ی اثر داروهای مختلف در پیشگیری از تهوع و استفراغ بعدازعمل جراحی انجام میشود. هدف: مقایسه ی اثر تزریق وریدی اندانسترون و گرانیسترون در پیشگیری از تهوع و استفراغ بعداز عمل جراحی سزارین در روش بی حسی نخاعی. روش: ما بطور تصادفی خانم هایی را که جهت انجام عمل جراحی سزارین تحت بی حسی نخاعی در بیمارستان 22 بهمن دانشگاه آزاد اسلامی مشهد قرار می گیرند انتخاب کردیم و بیماران به دو گروه 84 نفری تقسیم شدند که گروه اول 4 میلی گرم اندانسترون وریدی و گروه دوم 1 میلی گرم گرانیسترون وریدی قبل از انجام آنستزی دریافت کردند ودر پرسشنامه اطلاعات مربوط به بروز تهوع و استفراغ در یک ساعت اول از شروع بی حسی نخاعی ثبت، جمع آوری و مورد بررسی قرار دادیم. نتایج: در مطالعه ی ما در بررسی میزان تهوع از 84 نفر در گروه اندانسترون، 21نفر (25%) تهوع داشتند و از 84 نفر در گروه گرانیسترون 7نفر (8/3%) تهوع داشتند.(P-value=0/004) و در بررسی بروز استفراغ، از 84 نفر در گروه اندانسترون 7 نفر (8/3%) استفراغ داشتند و در گروه گرانیسترون هیچ موردی از استفراغ گزارش نشد. (P-value=0/014) یافته های ما بیانگر این است که یک میلی گرم گرانیسترون وریدی قبل از بی حسی نخاعی نسبت به 4 میلی گرم اندانسترون وریدی در پیشگیری از تهوع و استفراغ بعداز عمل جراحی سزارین مؤثرتر است. بحث: یافته های ما از اثربخشی بیشتر گرانیسترون نسبت به اندانسترون حمایت می کنند و پیشنهاد می شود مطالعات بیشتری برای بررسی اثر ترکیبی داروها در مقایسه با هریک از داروها به تنهایی برای پیشگیری از تهوع و استفراغ بعدازعمل جراحی در آینده انجام شود.
Background: Postoperative nausea and vomiting is caused by various factors and based on studies comparing the effects of various drugs in the prevention of postoperative nausea and vomiting. Purpose: To compare the effectiveness of intravenous Ondansetron and Granisetron in the prevention of nausea and vomiting after cesarean section in spinal anesthesia procedures. Method: We randomly assigned the women to cesarean surgery under spinal anesthesia in a 22 Bahman Hospital Islamic Azad University of Mashhad, and patients were divided into two groups of each 84 person, Group I, intravenously ondansetron 4 mg and Group II, Granisetron 1 mg intravenously before anesthesia received, and questionnaire data on nausea and vomiting during the first hour after anesthesia records, we collected and analyzed. Results: In our study 84 cases in the ondansetron group, 21 patients (25%) were had nausea and in Granistron group, 7 patients (8.3%) were had nausea. (P-value=0.004) The incidence of vomiting in the ondansetron group, 7 of 84 patients (8.3%) and vomiting was no reported in Granisetron group. (P-value=0.014) Our findings suggest that 1mg Granisetron intravenously before spinal anesthesia is more effective than 4mg Ondansetron intravenously in the prevention of nausea and vomiting after cesarean section. Discussion: Our findings support the effectiveness of Granisetron than Ondansetron. And recommended further studies to evaluate the effect of drug combination compared with either drug alone for the prevention of postoperative nausea and vomiting is performed in the future.
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