Comparative effect of dexamethasone, metoclopramide and combination of dexamethasone-metoclopramide administrations on postoperative nausea and vomiting prophylaxis in dog model

Subject Areas : Journal of Comparative Pathobiology

مهدی  Marjani, ¹ (ندارد)
علی  Kazemi, ² (ندارد)
A.R  Hashempour, ³ (ندارد)

Received: 2014-06-11 Accepted : 2014-10-16 Published : 2015-01-21

Keywords: Vomiting, Dexamethasone, Metoclopramide, Xylazine,

Abstract :

Xylazine is preanesthetic drug that have nausea and vomiting effects. This study was done inorder to assessment of the effects of dexamethasone, metoclopramide and the combination ofdexamethasone - metoclopramide administrations in prophylaxis of nausea and vomiting afterxylazine administration in dogs.15 mixed breed dogs with average weight 18.9±5 Kg were randomly selected in 3 groupsincluding intravenous (I.V) dexamethasone 1mg/kg , I.V metoclopramide 0.5mg/kg and combination of dexamethasone - metoclopramide (0.5 -1 mg/kg). For induction of anesthesia inall groups, initially I.V diazepam (0.2 mg/kg) then I.V xylazine ( 2 mg/kg) and I.V morphine (2mg/kg) were administrated and dexamethasone, metoclopramide and combination ofdexamethasone-metoclopramide were injected and dogs were underwent the laparotomytechnique. Anesthetic and recovery times, also nausea and vomiting effects at 30 min, 2, 4, 8and 24 h after anesthesia were recorded and results were analyzed by ANOVA and (P < 0.05)were considered significant.Duration of anesthesia at dexamethasone group were 48.2±2.8 min, metoclopramide group51.7±2.3 min and in dexamethasone-metoclopramide group 45.7±2.3 min, respectively.Significant difference was not seen at duration of anesthesia between three groups (P> 0.05)none was seen nausea and vomiting.Single or co-administration of dexamethasone and metoclopramide prevents nausea andvomiting in operation and recovery period.