List of Articles Phytochemical

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  1 - A comparative study on fruit extract of Ficus auriculata l.: GC-MS profiling, phytochemical composition, biological activities and in-silico ADMET study
  NISHA MEHRA GARIMA TAMTA SHISHIR TANDON VIVEKA NAND MANISH PANT VINITA GOURI
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  2 - Evaluation of triterpenes isolated from stems of Pouteria macahensis T. D. Penn. against Proteus mirabilis
  Gabriel da Silva Amaral Hermerson Dantas dos Santos Aline Oliveira da Conceição Fernando Faustino de Oliveira Rosilene Aparecida de Oliveira
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  3 - Phytochemical, antioxidant and antibacterial properties in different concentrations of Physalis alkekengi L. extract
  simin Arian Seyedeh Fatemeh Habib Hosseini
  10.30495/ejmp.2022.1946341.1665
  With the increasing resistance of bacteria to antibiotics and their side effects, the use of medicinal plants in the treatment of bacterial infections is increasing. The aim of this study was to evaluate the phytochemical, antioxidant, and antibacterial properties of di More

  With the increasing resistance of bacteria to antibiotics and their side effects, the use of medicinal plants in the treatment of bacterial infections is increasing. The aim of this study was to evaluate the phytochemical, antioxidant, and antibacterial properties of different concentrations of methanolic extract of Physalis alkekngi. For this purpose, the calyx and fruit of the P. alkekengi L. were collected from an area near the city of Tonekabon in the summer of 2019 from a height of 120 meters and the antimicrobial activity of the extracts on pathogenic bacteria was determined by disk diffusion methods, MIC, and MBC. Total phenol and flavonoid contents were measured by folin-ciocalteu reagent and aluminum chloride colorimetric method, respectively. In addition, total anthocyanin was measured by spectrophotometry as well as antioxidant activity of extract using DPPH method. Based on the results, the highest total phenol content at a concentration 50 mg-1 ml of calyx extract was 32.92±1.738 mgEGA g-1 DW. Also, the content of flavonoid and anthocyanin compounds in the calyx extract was more than that of the fruit extract. Based on the results of antioxidant activity also showed  that the highest DPPH radical inhibitory effect were obtained at concentrations of 100 and 150 mg/ml of calyx extract 51.43% and 51.58%, respectively. In addition, calyx and fruit extracts showed significant inhibitory activity against the studied bacteria as the highest inhibitory effect on Staphylococcus aureus was obtained at a concentration of 1000 mg -1ml of calyx and fruit extracts. The results of this study indicated that the calyx and fruit extracts of P. alkekengi are rich in antioxidant compounds, especially phenolic compounds, and the antimicrobial activity of the extracts showed a significant positive correlation with total phenol content. Therefore, the antimicrobial properties of the calyx and fruit extracts may be attributed to their phenolic compounds and these extracts can be recommended for medicinal applications. Manuscript profile
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  4 - Phytochemical investigation of the extract of different organs of Silene conoidea. L. using gas chromatography-mass spectrometer in Sabzevar
  Samira Eghbali Mino Qalichi Akram Taleghani
  Silene weed plant (Silene conoidea. L) is a medicinal and edible plant from the Caryophyllacea family. The medicinal properties of this species are mostly attributed to its phenolic chemical compounds. This plant in traditional and modern medicine, used for treatment of More

  Silene weed plant (Silene conoidea. L) is a medicinal and edible plant from the Caryophyllacea family. The medicinal properties of this species are mostly attributed to its phenolic chemical compounds. This plant in traditional and modern medicine, used for treatment of skin infections, and blood coagulation which its medicinal properties are attributed to phenolic compounds. In this research, flower, stem, leaf and root of S. conoidea collected from Sabzevar in Spring 2022, the chemical compositions of chloroform and dichloromethane fractions were reported by GC-MS. In order to preparation of fractions for all the organs under the same conditions, petroleum ether was used for defatting, and chloroform and dichloromethane were used to extract the effective phytochemicals by maceration method. Analysis GC-MS of chloroform fractions showed that terpene derivatives, phenolic derivatives, hydrocarbons, fatty acids, heterocyclic derivatives, phenylpropanes, silane derivatives and steroids are the main constituent compounds in all organs. Hydrocarbon derivatives (69.16%) in flower, terpene derivatives (40.46%) in stem and fatty acid derivatives (40.46% and 63.98%) respectively in leaf and root are the most constituent compounds in chloroform fractions. Also, the analysis GC-MS of dichloromethane fractions showed that terpene derivatives (47.62% and 40.53%) in leaf and stem and silane derivatives (52.70%) in root are the most constituent compounds, respectively. The properties of solvents play an important role in determining the extraction of phytochemical compounds with unique biological properties. In general, the results of this research show that the non-polar extract of chloroform and the stem of plant have valuable effective substances, especially terpene compounds for medicinal purposes. These results suggested that other genetic resources of S. conoidea can be further explored to screen high bioactive compounds and purification of phytochemical compounds, which are valuable to produce, expand, and develop natural antioxidants in production of bio-medicine and food. Manuscript profile
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  5 - A comparative study on the extracts from the fruits of Ficus auriculata L.: GC-MS profiling, phytochemical composition, biological activities and in-silico ADMET study
  Garima Tamta Nisha  Mehra Shishir Tandon Viveka  Nand Manish Pant Vinita Gouri
  Ficus auriculata L., commonly known as, “elephant ear fig” is a species of fig tree in Moraceae family and globally found in tropical and subtropical forests. The present comparative study investigated the GC-MS analysis, phytochemical composition, in vitro antioxidant More

  Ficus auriculata L., commonly known as, “elephant ear fig” is a species of fig tree in Moraceae family and globally found in tropical and subtropical forests. The present comparative study investigated the GC-MS analysis, phytochemical composition, in vitro antioxidant assays and antidiabetic activity of methanol and hexane extracts from the fruits of Ficus auriculata which was collected from two different agro-climatic conditions in Uttarakhand, namely Almora (Hill region) and Haldwani (Tarai region). The GC-MS analysis of Almora unripe hexane fruit extract (AUFHE) and Haldwani unripe hexane fruit extract (HUFHE) gave rise to the characterization of two chemical profiles composed of 37 and 40 bioactive compounds with γ-sitosterol (15.46% and13.44%) as the most abundant component, respectively. Moreover, in Almora unripe methanol fruit extract (AUFME) and Haldwani unripe methanol fruit extract (HUFME), 24 and 23 bioactive compounds were characterized among which linoleic acid (71.41%) and hexadecadienoate (26.42%) were the most prevalent compounds, respectively. In view of the obtained results, HUFME exhibited prominent total phenolic, flavonoid and tannin contents. AUFME also showed potent antioxidant activity when using DPPH (2,2-diphenylpicrylhydrazyl) radical scavenging activity assay (IC50 =447.45 ± 0.53 µg/mL), whereas strong metal chelation assay was found for HUFHE (IC50= 502.07 ± 2.50 µg/mL). Furthermore, AUFME and HUFME displayed potent anti-diabetic activity. In addition, ADMET study predicted that F. auriculata could be considered an effective bioactive source of phytoconstituents for various biological efficacies. The observed pharmacological properties could be attributed to the presence of polyphenols, flavonoids and fatty acids in F. auriculata fruit. Manuscript profile
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  6 - Antioxidant properties and anticancer activity of Olea europaea L. olive and Ficus carica fruit extracts against pancreatic cancer cell lines
  Nadia Nadia Dekdouk Souad Ameddah Chawki Bensouici Meghboun  Ibtissem Menad Ahmed Fátima Martel
  Olea europaea (OFE) and Ficus carica (FFE) extracts have shown anticancer activity. The currents report, we aim to evaluate the phytochemical composition, antioxidant properties and anticancer activity of OFE and FFE against PANC-1 and AsPC-1 pancreatic cancer cell line More

  Olea europaea (OFE) and Ficus carica (FFE) extracts have shown anticancer activity. The currents report, we aim to evaluate the phytochemical composition, antioxidant properties and anticancer activity of OFE and FFE against PANC-1 and AsPC-1 pancreatic cancer cell lines. OFE possessed higher phenolic, flavonoid content and antioxidant ability than FFE. OFE and FFE induced a cytotoxic effect and their combination resulted in an increased cytotoxicity. OFE showed an antiproliferative effect while FFE had no effect. Combination of the two extracts resulted in an antiproliferative effect similar to that of OFE. OFE showed an antimigratory effect, while FFE exhibited a promigratory effect. Interestingly, combination of the two extracts resulted in an anti-migratory effect similar to that caused by OFE. In view of the findings of this study, these extracts could be considered potential sources of natural compounds with antioxidant and anti-pancreatic cancer effects. The combination of these extracts should be further investigated in the context of pancreatic cancer. Manuscript profile