List of Articles Alireza Barari

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  1 - The Effect of Moderate Intensity Interval Training on Mitochondrial Biogenesis Markers of Rats Fed a High Fat Diet
  Ahmad Khajvand Abedini Ahmad Abdi Alireza Barari ghasem Torabi Palat Kaleh mostafa Kazemi Masoomeh Alsadat Mirshafaei
  10.30495/pah.2022.693883
  PGC-1α has been reported to play an essential role in skeletal muscle mitochondrial biogenesis in collaboration with Nrf2. The aim of the present study was to investigate the effect of moderate intensity interval training on mitochondrial biogenesis markers in mic More

  PGC-1α has been reported to play an essential role in skeletal muscle mitochondrial biogenesis in collaboration with Nrf2. The aim of the present study was to investigate the effect of moderate intensity interval training on mitochondrial biogenesis markers in mice fed a high fat diet. In this experimental study, 24 male rats were randomly divided into three groups (n=9): Normal Diet (ND), High-Fat Diet (HFD) and High-Fat Diet +Training (HFDT). The training group performed moderate intensity interval training (MIIT) on the treadmill for 8 weeks and 5 sessions per week. The MIIT program includes 13 repetitions of 4-minute activity with an intensity of 16-25 meters per minute, with 2-minute rest periods. Data were analyzed using ANOVA at p<0.05. There was a significant decrease in the relative expression of PGC-1α (p=0.0001) and Nrf2 (p=0.0001) in HFD groups compared to CN. Also, the relative expression of PGC-1α (p=0.0001) and Nrf2 (p=0.0001) increased significantly in HFDT groups compared to HFD. It seems that MIIT by increasing the expression of PGC-1α and Nrf2 is a suitable method to improve the performance of mitochondrial biogenesis in HFD-fed rats. Manuscript profile