Investigating the effect of eight weeks of endurance training on the serum levels of dipeptidyl peptidase-4, endurance performance and some anthropometric indices in obese women
Subject Areas : Role of Genes in Health
Maryam Kamari
1
,
مسعود رحمتی
2
,
مهدی بوستانی
3
1 - Department of Physical Education, Borujerd Branch, Islamic Azad University, Borujerd, Iran
2 - گروه تربیت بدنی دانشکده ادبیات و علوم انسانی دانشگاه لرستان
3 - استادیارگروه تربیت بدنی، دانشگاه آزاد اسلامی واحد اهواز، اهواز، ایران
Keywords: DPP-4, exercise training, VO2max, obesity,
Abstract :
Introduction: Dipeptidyl peptidase-4 (DPP-4), is related to many metabolic diseases such as obesity. The purpose of this study was to investigate the effect of eight weeks of endurance training on the serum level of DPP-4, endurance performance and some anthropometric indicators in obese women. Materials and Methods: 23 inactive obese women aged 30 to 45 with a BMI of 30.5±5.37 who voluntarily and purposefully participated in the study. The subjects were randomly divided into two experimental groups (N=12) and control (N=11). First, pre-test measurements related to blood sample, height, weight, BMI, fat percentage, VO2max and waist to hip ratio of the subjects were performed. Then, the experimental group participated in 8 weeks of endurance training and the measurements of the post-test were recorded. MANCOVA test was used to check the significance of the difference between the groups. Results: The results showed that there is no significant difference between the research variables in the pre-test (p<0.05). MANCOVA showed that there was a significant decrease in weight (P=0.001), BMI (P=0.001), fat percentage (P=0.001) and DPP-4 (0.001) =P), and there is a significant increase in the amount of maximum oxygen consumption (P=0.038) after the end of the study in training group compared to the control group. Conclusion: It was found that eight weeks of endurance training reduces the serum level of DPP-4 and improves body composition and endurance performance in obese women. Therefore, it is suggested that obese women use these exercises to improve their health, body composition and increase their endurance capacity.
1. Koçak FA, Kurt EE, Milletli Sezgin F, Şaş S, Tuncay F, Erdem HR. The effect of balneotherapy on body mass index, adipokine levels, sleep disturbances, and quality of life of women with morbid obesity. International Journal of Biometeorology. 2020;64(9):1463-72.
2. Sarma S, Sockalingam S, Dash S. Obesity as a multisystem disease: Trends in obesity rates and obesity‐related complications. Diabetes, Obesity and Metabolism. 2021;23:3-16.
3. Lobstein T, Brinsden H, Neveux M. World Obesity Atlas 2022. 2022.
4. Choi H, Kim J, Lim SC, Kim G, Yun H, Choi H. Dipeptidyl peptidase 4 promotes epithelial cell transformation and breast tumourigenesis via induction of PIN1 gene expression. British journal of pharmacology. 2015;172(21):5096-109.
5. Hoffstedt J, Arvidsson E, Sjölin E, Wåhlén K, Arner P. Adipose tissue adiponectin production and adiponectin serum concentration in human obesity and insulin resistance. The Journal of Clinical Endocrinology & Metabolism. 2004;89(3):1391-6.
6. Nargis T, Chakrabarti P. Significance of circulatory DPP4 activity in metabolic diseases. IUBMB life. 2018;70(2):112-9.
7. Drucker DJ. Dipeptidyl peptidase-4 inhibition and the treatment of type 2 diabetes: preclinical biology and mechanisms of action. Diabetes care. 2007;30(6):1335-43.
8. Lamers D, Famulla S, Wronkowitz N, Hartwig S, Lehr S, Ouwens DM, et al. Dipeptidyl peptidase 4 is a novel adipokine potentially linking obesity to the metabolic syndrome. Diabetes. 2011:DB_101707.
9. Conarello SL, Li Z, Ronan J, Roy RS, Zhu L, Jiang G, et al. Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance. Proceedings of the National Academy of Sciences. 2003;100(11):6825-30.
10. Silva Junior WS, Souza MdGC, Nogueira Neto JF, Bouskela E, Kraemer-Aguiar LG. Dipeptidyl peptidase 4 activity is related to body composition, measures of adiposity, and insulin resistance in subjects with excessive adiposity and different degrees of glucose tolerance. Journal of diabetes research.2019.
11. Ohnuma K, Hatano R, Morimoto C. DPP4 in anti-tumor immunity: going beyond the enzyme. Nature immunology. 2015;16(8):791.
12. Ghasemnian A, Kordi M, Ghaeini A, Ghorbanian B, Hedayati M. Changes of Plasma Visfatin and Insulin Resistance in Overweight and Obese Non-athlete Adolescents following an Eight-Week-Endurance Rope Training. Journal of Zanjan University of Medical Sciences & Health Services. 2014;22(94). [In Persian]
13. Malin SK, Huang H, Mulya A, Kashyap SR, Kirwan JP. Lower dipeptidyl peptidase-4 following exercise training plus weight loss is related to increased insulin sensitivity in adults with metabolic syndrome. Peptides. 2013;47:142-7.
14. Tabibirad S, Abednatanzi H, Ghazalian F, Gholami M. Effects of aerobic training on dipeptidyl peptidase-4 and glucagon-like peptide-1 in obese women with type 2 diabetes. Iranian Journal of Diabetes and Metabolism. 2019;18(5):275-81. [In Persian]
15. Fathi R, Baghersalimi M, Nazemi M, Khosravi A. The effect of eight weeks interval and continuous walking on serum levels of dipeptidyl peptidase-4 and insulin resistance index in obese girls aged 9-11 years old. Metabolism and Exercise. 2018;8(1):29-42. [In Persian]
16. Carter R, Mouralidarane A, Ray S, Soeda J, Oben J. Recent advancements in drug treatment of obesity. Clinical medicine. 2012;12(5):456.
17. Rashidlamir A, Alizadeh A, Ebrahimiatri A, Dastani M. The effect of four-week period of aerobic exercise with cinnamon consumption on lipoprotein indicates and blood sugar in diabetic female patients (type 2). SSU_Journals. 2013;20(5):605-14. [In Persian]
18. khirabadi j, etemad z, azizbeigi k, mohamadzadeh salamat k. The effect of eight weeks of high-intensity interval training with caloric restriction and spirulina supplementation on inflammatory factors in heart tissue of rats under high-fat diet. Journal of Sport and Exercise Physiology. 2023;16(1):67-79. [In Persian]
19. She J, Nakamura H, Makino K, Ohyama Y, Hashimoto H. Selection of suitable maximum-heart-rate formulas for use with Karvonen formula to calculate exercise intensity. International journal of automation and computing. 2015;12:62-9.
20. Balady GJ, Williams MA, Ades PA, Bittner V, Comoss P, Foody JM, et al. Core components of cardiac rehabilitation/secondary prevention programs: 2007 update: A scientific statement from the american heart association exercise, cardiac rehabilitation, and prevention committee, the council on clinical cardiology; the councils on cardiovascular nursing, epidemiology and prevention, and nutrition, physical activity, and metabolism; and the american association of cardiovascular and pulmonary rehabilitation. Circulation. 2007;115(20):2675-82.
21. Rostamizadeh M, Elmieh A, Rahmani Nia F. Effects of aerobic and resistance exercises on anthropometric indices and osteocalcin, leptin, adiponectin levels in overweight men. Journal of Arak University of Medical Sciences. 2019;22(1):85-95. [In Persian]
22. Mohammadhassani F, Esfandiarinezhad A, Asad MR, Jafari A. The effects of endurance training and high intensity interval training on orexin-A and anthropometric parameters in obese adolescent boys. Journal of School of Public Health & Institute of Public Health Research. 2015;13(1).
23. Kazemi A, Kerendi H, Iranmanesh M. The Effects of Eight Weeks of Aerobic Exercise on Plasma Nesfatin-1, Insulin, Glucose and Insulin Resistance in Obese Women. Journal of Isfahan Medical School. 2023;41(709):110-7. [In Persian]
24. Samadi M, Bagherpoor Goll T, Fattahi MR, Rostamkhani F, Riyahi Malayeri S. Effect of continuous aerobic training and high-intensity interval training on some anthropometric indicators of overweight and obese military personnel. Journal of Exercise & Organ Cross Talk. 2022;2(4):136-41.
25. Manna I, Lal Khanna G, Chandra Dhara P. Effect of training on anthropometric, physiological and biochemical variables of U-19 volleyball players. 2012.
26. Rahmati M, Kazemi A, Kerendi H, Sheibak A. The effect of HIIT with supplementation of cinnamon on DPP4 concentration, insulin resistance, BMI and Vo2max in overweight boys. Journal of Applied Exercise Physiology. 2019;15(29):119-32. [In Persian]
27. Abbassi-Daloii A, Shaghi R, Ahmadi M, Kohanpour MA. determine the effects of resistance training on serum levels of GLP-1, DPP-4 and insulin resistance in obese men. Journal of Sport and Exercise Physiology. 2017;10(1):21-30. [In Persian]
28. Reinehr T, Roth CL, Enriori PJ, Masur K. Changes of dipeptidyl peptidase IV (DPP-IV) in obese children with weight loss: relationships to peptide YY, pancreatic peptide, and insulin sensitivity. Journal of Pediatric Endocrinology and Metabolism. 2010;23(1-2):101-8.
29. Lee SS, Yoo JH, So YS. Effect of the low-versus high-intensity exercise training on endoplasmic reticulum stress and GLP-1 in adolescents with type 2 diabetes mellitus. Journal of physical therapy science. 2015;27(10):3063-8.
30. Akbarpour M, Fathollahi Shoorabeh F, Mardani M, Amini Majd F. Effects of eight weeks of resistance training and consumption of pomegranate on GLP-1, DPP-4 and glycemic statuses in women with type 2 diabetes: A randomized controlled trial. Nutrition and Food Sciences Research. 2021;8(1):5-10. [In Persian]
31. Lamers D, Famulla S, Wronkowitz N, Hartwig S, Lehr S, Ouwens DM, et al. Dipeptidyl peptidase 4 is a novel adipokine potentially linking obesity to the metabolic syndrome. Diabetes. 2011;60(7):1917-25.
32. Boschmann M, Engeli S, Dobberstein K, Budziarek P, Strauss A, Boehnke J, et al. Dipeptidyl-peptidase-IV inhibition augments postprandial lipid mobilization and oxidation in type 2 diabetic patients. The Journal of Clinical Endocrinology & Metabolism. 2009;94(3):846-52.
33. El-Alameey IR, Ahmed HH, Abushady MM. Dipeptidyl peptidase IV: a target for improving metabolic syndrome components in obese children and adolescents. Biomedical and Pharmacology Journal. 2019;12(04):1701-13.
34. sayah A. The effect of weight loss caused by three methods of energy balance (caloric restriction, aerobic exercise with three different intensities (high, moderate, low) and caloric restriction and aerobic exercise combination] on the expression of DPP-4 gene and plasma levels of GIP, GLP1, DPP- 4 and insulin resistance index in obese rats. 2016. [In Persian]
35. Keller AC, Knaub LA, Miller MW, Birdsey N, Klemm DJ, Reusch JE. Saxagliptin restores vascular mitochondrial exercise response in the Goto-Kakizaki rat. Journal of cardiovascular pharmacology. 2015;65(2):137.
36. Tanimura Y, Aoi W, Mizushima K, Higashimura Y, Naito Y. Combined treatment of dipeptidyl peptidase‐4 inhibitor and exercise training improves lipid profile in KK/Ta mice. Experimental Physiology. 2019;104(7):1051-60.