Effects of garlic and stevia extract along with endurance activity on anxiety-like behaviors of male Wistar rats induced obesity with high-fat diet
Subject Areas : Role of Genes in Health
Mahsa Taleshi
1
,
reza rezaeeshirazi
2
,
Javad Ziaolhagh
3
,
Habib Asgharpour
4
1 - Islamic Azad University, Aliabad Katoul
2 - Islamic Azad University
3 - Shahrood Branch
4 - Faculty member
Keywords: Obesity, garlic extract, Aerobic physical activity, cross maze, stevia extract,
Abstract :
Aim of the present study was to investigate the effect of supplementation of garlic and stevia extract along with endurance activity on anxiety-like behaviors of male Wistar rats induced obesity with a high-fat diet. In this fundamental and experimental research, in order to induce obesity, 50 three-week-old male Wistar rats were exposed to a high-fat diet for 12 weeks, and then in 7 healthy control groups (HC), obese (HFD), garlic (G), stevia (St), aerobic (ET), garlic+aerobic (ET+G) and stevia+aerobic (ET+St) were randomly divided. Aerobic exercises including 30 minutes a day, 8 m/min and 5 days a week and garlic and stevia extract with a concentration of 250 mg/kg were also added to the water consumed daily. Cross-maze test was used to measure anxiety-like behaviors. ANOVA was used to determine the difference between groups and a significance level of 0.05 was considered. The results showed that the percentage of entering the open arm in the 12 weeks of high-fat diet in the obese group compared to the control group was significantly reduced (P=0.001) and in the 8 weeks exposed to exercise and extract interventions, the ET group (0.001) P=0), ET+G (P=0.001) and ET + St (P=0.001), had a significant increase compared to the HFD group. The present study showed that induction of obesity increases anxiety in male Wistar rats and it seems that the combination of aerobic exercise with garlic extract, the combination of aerobic exercise and stevia extract, aerobic exercise, stevia and garlic are effective in improving this process.
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