The effect of UCP1 and PPARα genotypes on endurance performance and body composition of obese women after eight weeks of endurance training

Subject Areas : Role of Genes in Health

Maryam  Kamari ¹ (Department of Physical Education, Faculty of Humanities, Islamic Azad University, Borujerd Branch, Borujerd, Iran)
Masoud  Rahmati ² (Department of Physical Education and Sport Sciences, Faculty of Literature and Human Sciences, Lorestan University, Khoramabad, Iran)
Mehdi  Boostani ³ (Department of Physical Education, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran)

Received: 2023-07-15 Accepted : 2023-11-06 Published : 2023-11-22

Keywords: exercise training, Oxygen Consumption, body composition, UCP1, PPARα,

Abstract :

Introduction: Considering the role of UCP1 and PPARα in fat metabolism, the aim of this study was to investigate the effect of UCP1 and PPARα genotypes on endurance performance and body composition of obese women after an endurance training program.Materials and Methods: 23 obese women (30-45 years old, BMI=30) voluntarily participated in the research. Subjects participated in an endurance training program (8 weeks, 5 sessions per week and 30 minutes in each session, by intensity of 55-75% of heart rate reserve). The subjects' height, weight, BMI, body fat percentage, waist-to-hip ratio, and VO2max were evaluated before and after the training program. In order to extract DNA and observe the genetic profile by RFLP method, saliva samples were collected. Subjects were placed in CG and GG groups for PPARα gene and CC and CT groups for UCP1 gene. The frequency of genotypes was checked with chi-square test and the difference between variables was checked with independent t-test.Results: The results of UCP1 gene in CC and CT genotype groups showed that there is no significant difference between pre to post test of VO2max (p=0.823), BMI (p=0.683), fat percentage (p=0.275), waist-to-hip ratio (p=0.113). Also, the results of PPARα gene in CG and GG genotype groups showed that there is no significant difference between pre to post test of VO2max (p=0.739), BMI (p=0.24), fat percentage (p=0.493) and waist-to-hip ratio (p=0.447).Conclusion: UCP1 and PPARα genotypes have no effect on endurance performance and body composition of obese women after an endurance training program.