Association between IL-12 Receptor beta-1 gene polymorphisms and Tuberculosis between Iranian Population
Subject Areas : Molecular Microbiology
Noor olhoda
Saadaee Jahromi
1
(Department of Microbiology, Islamic Azad University, Jahrom Branch, Jahrom, Iran)
Parissa
Farnia
2
(Mycobacterium Research Center (MRC), National Research Institute Of Tuberculosis and Lung Disease (NRITLD))
Mohammad
Kargar
3
(Department of Microbiology, Islamic Azad University, Jahrom Branch, Jahrom, Iran)
Mehdi
Kazem pour
4
(Mycobacterium Research Center (MRC), National Research Institute Of Tuberculosis and Lung Disease (NRITLD))
Jamileh
Nowroozi
5
(Department of Microbiology, Shahid Beheshti University of Medical sciences, Tehran, Iran)
Mohammad Reza
Masjedi
6
(Mycobacterium Research Center (MRC), National Research Institute Of Tuberculosis and Lung Disease (NRITLD))
Aliakbar
Velayati
7
(Mycobacterium Research Center (MRC), National Research Institute Of Tuberculosis and Lung Disease (NRITLD))
Keywords: Polymorphism, Interleukin 12, Mycobacteium tuberculosis, Beta-1 receptor,
Abstract :
Background and objectives: Tuberculosis (TB) is the most common cause of death due to infectious disease, worldwide. In fact only 10% of people infected with Mycobacterium tuberculosis develop clinical disease which suggests , the role of host genetic factors in susceptibility against TB. For this reason, we aimed to determined IL-12 gene polymorphism among PTB cases. Material and method: A case-control study was carried out in one hundred twenty TB patient and one hundred sixty seven healthy control individuals. The Single Nucleotide Polymorphism (SNP ) in 5 regions of IL12 RB1 gene +705A/G +1158T/C, +1196G/C,+1664C/T and +1637 G/A were determinate by PCR-RFLP. Results: No significance differences were detected at +1664 C/T and +1637 G/A allele frequencies. Conclusion: In this study, the IL-12 gene polymorphism at +1664 C/T and +1637G/A allele were associated with susceptibility against TB. Although, further studies suggested on more number of samples.