Sports training is considered as a tool to increase the protective power of the heart against stress.The aim of this study is to investigate the effect of pre-training with intense intermittent exercise on myocardial Hsp70 and SOD following acute myocardial infarction in male rats. 20 8-week-old male Wistar rats (with an average weight of 224.41±5.1 grams) were divided into 4 groups: control, exercise, stroke, and stroke-exercise. The training groups did two weeks of intense interval training in four sections. The first part, three days of training every day, two sessions, each day, and each session includes 4 intense intervals of two minutes at a speed of 35 to 40 meters per minute, and between each interval, a 2 minute active rest period at a speed of 25 to 30 meters per minute. Considered in the second part, two days of training, each day consisted of two training sessions containing 4 periods of intense activity of 2 minutes (40 to 45 m/min) and 3 periods of active rest of 2 minutes (28 to 32 m/min). The third part also included 5 intense periods (40 to 45 m/min) and 4 active rest periods (28 to 32 m/min) in three training days. The fourth part included two training days with the same intensity as the third part, but with an increase in activity and active rest in each session. Finally, Hsp70 and SOD were measured along with the amount of infarcted area. Heart damage enzymes (CK and LDH) were also measured in serum. The one-way analysis of variance test showed that two weeks of intense intermittent exercise, although it reduces the infarcted area of the heart of rats, but there were significant changes in Hsp70 and SOD after acute myocardial infarction between the stroke-exercise and stroke groups. Does not cause, while the measured heart damage enzymes (CK and LDH) showed a significant decrease in the stroke-exercise group compared to the stroke group. Therefore, two weeks of HIIT training can protect the heart from acute ischemia-induced damage through signaling pathways.
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