Spleen is the largest lymphatic organ of the body and plays a role in blood purification, storage of red blood cells, removal of damaged old red blood cells and creation of specific immune responses. Some studies have shown that the spleen tissue has differences in some
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Spleen is the largest lymphatic organ of the body and plays a role in blood purification, storage of red blood cells, removal of damaged old red blood cells and creation of specific immune responses. Some studies have shown that the spleen tissue has differences in some species. Since Balb/c and C57BL/6 bi-strain mice are chosen as the first choice in many biological researches, it is necessary to carefully evaluate the anatomical, histological and genetic differences between them in order to develop study models be chosen correctly. Therefore, the present study was conducted with the aim of investigating the morphometric and histological characteristics of spleen tissue in Balb/c and C57BL/6 mice. 10 Balb/c female mice and 10 C57BL/6 female mice were bred in the animal house under the same conditions. Then the spleen of mice was examined in terms of morphometric and histological characteristics. The data obtained from two groups were analyzed with t-set method and p < 0.05 was considered significant. The results showed that the shape and color of the spleen in mice do not differ significantly. The average spleen weight in Balb/c mice was slightly higher than that of C57BL/6 mice, which was not statistically significant. In the slides prepared from the spleen tissue of Balb/c and C57BL/6 mice, no visible difference was detected between the mice's spleen in terms of histology.
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