This study was conducted to determine the effects of supplemented curcumin (CMN), derived from plant Curcuma longa, extract on performance and blood parameters of acetaminophen (ACT) induced quail hepatic injury. 240 quails from 0-37 days of age were used in a completely randomized design with 4 treatments of 4 replicates each and 15 chickens per replicate. All groups received 750 mg/kg body weight oral doses of ACT at 12 days of age. Japanese quails were divided into four groups: control (no CMN), commercial diet with 20 g CMN per ton, commercial diet with 40 g CMN per ton and commercial diet with 60 g CMN per ton. Feed intake and body weight gain were recorded weekly. Blood albumin, glucose, total protein, triglyceride, aspartate aminotransferase, alanine aminotransferase, bilirubin, uric acid and creatinine were determined at 28 and 35 days of age. Adding curcumin to the diets significantly increased serum aspartate aminotransferase at 28 days of age (P<0.05) and decreased triglyceride and bilirubin at 35 days of age (P<0.05). There were no significant differences in performance and other blood parameters among the treatment groups at 28 and 35 days of age. The data indicated that curcumin is a natural antioxidant hepatoprotective agent against hepatotoxicity induced by acetaminophen model. Thus, curcumin may have a therapeutic value in drug-induced hepatotoxicity as well as in acetaminophen therapy. Manuscript profile

Sodium bentonite can bind to dietary pigment and decreases yolk color scale. Sodium bentonite is one of the main parts of Formycine® Gold, the effect of different levels of Formycine® Gold and dietary pigment on egg quality, egg yolk color and performance criteria of laying hens from 26 to 34 week of age were studied. One hundred ninety two Hy-Line hens were divided into 24 groups of 8 birds each and randomly assigned to 6 dietary treatments of 4 replicates each. The study was conducted in a completely randomized design with a 2 × 3 factorial arrangement of treatments based on 2 levels of pigment (0 and 0.4 g/kg) and 3 levels of Formycine® Gold (0, 1 and 2 g/kg). Feed intake, body weight, feed to egg ratio and egg productions were recorded at the end of the weeks 28, 30, 32 and 34. Egg quality characteristics including egg weight, specific gravity, yolk color scale, egg shell percentage and thickness were evaluated every other week. Formycine® Gold and dietary pigment had no effect on performance for entire of the experiment. Egg shell weight and thickness increased by 0.4 g/kg dietary pigment at 29-30 weeks of age. Hen-day egg production was not influenced by dietary treatments. Egg specific gravity was similar in hens fed different levels of Formycine® Gold and pigment, except for 29-30 weeks of age. Regardless of Formycine® Gold levels, diet supplemented with pigment considerably increased yolk color scale. It seems that, by decreasing the amount of sodium bentonite in Formycine® Gold, it can be used without any adverse effect on egg quality, egg pigmentation and performance of laying hens. Manuscript profile