Study on the effects of consumption of milk containing Lactobacillus acidophilus on serum lipid trends and weight gain of rats fed high lipid diet

Subject Areas : Veterinary Clinical Pathology

حمید Mirzaei ¹ , مهران Mesgari abbasi ² , عیسى Tajmohammadi ³

1 - Department of Food Hygiene, Faculty of Veterinary Medicine, Islamic Azad University, Tabriz Branch, Tabriz, Iran
2 - Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3 - Department of Clinical Sciences, Faculty of Veterinary Medicine, Islamic Azad University, Urmia Branch, Urmia, Iran

Received: 2008-04-22 Accepted : 2008-07-17 Published : 2008-02-20

Keywords: Milk, Rat, Lactobacillus acidophilus, lipid trends, high lipid diet,

Abstract :

      Despite the significant progresses made in the reduction of mortality due to cardiovascular diseases, they are still the primary cause of death in many countries and hyperlipidemia is an important causal agent of cardiovascular diseases. Probiotics are food supplements containing live microbes which balance the flora of the digestive system and produce positive effects in the host body. L.acidophilus is a beneficial bacterium used in the production of probiotic products .The aim of this study is to evaluate the effects of consumption of milk containing L.acidophilus on serum lipid trends of rats fed high lipid diet. This is an experimental study in which 30 male albino Wistar rats with a body weight of 200±15 gr. were randomly allocated to two groups of treatment and control each containing 15 rats which were adapted to a high lipid diet (11.74%) and water containing 25% milk within a week. Rats in both groups received high lipid diet and water containing 25% milk for 60 days with the exception that rats in the treatment group received water containing L. acidophilus at a level of 109 CFU/rat/day throughout the experiment. Independent t-test revealed that at a level of α= 0.05, mean levels of total cholesterol and LDL-C of rats in the treatment group was significantly lower than the control group (p<0.05), and HDL-C of rats in the treatment group was significantly higher than the control group (p<0.05), but the mean levels of triglyceride and VLDL-C was not significantly different. Also increase in body weight was significantly higher in the treatment group compared with the control group (p<0.01). On the whole, long term daily consumption of milk containing L. acidophilus improves serum lipid trends by lowering total cholesterol level and LDL-C and increasing HDL-C and also increases the rate of body growth.  

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