Ficusanol, a new cinnamic acid derivative and other constituents from the roots of Ficus exasperata Vahl. (Moraceae) with antioxidant and cytotoxic activities

Subject Areas : Phytochemistry: Isolation, Purification, Characterization

Stevine Claudiale  Popwo Tameye ¹ (Analytical, Structural and Materials Chemistry Laboratory, Department of Chemistry, Faculty of Sciences, University of Douala. P.O. Box 24157 Douala, Cameroon)
Jean Claude  Ndom ² (Analytical, Structural and Materials Chemistry Laboratory, Department of Chemistry, Faculty of Sciences, University of Douala. P.O. Box 24157 Douala, Cameroon)
Edwige Laure  Nguemfo ³ (Département des Sciences Biologiques, Faculté de Médecine et des Sciences Pharmaceutiques (FMSP), Université de Douala, BP 2701 Douala, Cameroun)
Jean Duplex  Wansi ⁴ (Analytical, Structural and Materials Chemistry Laboratory, Department of Chemistry, Faculty of Sciences, University of Douala. P.O. Box 24157 Douala, Cameroon)
Juliette Catherine  Vardamides ⁵ (Analytical, Structural and Materials Chemistry Laboratory, Department of Chemistry, Faculty of Sciences, University of Douala. P.O. Box 24157 Douala, Cameroon)
Anatole Guy Blaise  Azebaze ⁶ (Analytical, Structural and Materials Chemistry Laboratory, Department of Chemistry, Faculty of Sciences, University of Douala. P.O. Box 24157 Douala, Cameroon)

Received: 2019-07-18 Accepted : 2020-01-20 Published : 2020-03-01

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References:

Adebayo, E.A., Ishola, O.R., Taiwo, O.S., Majolagbe, O.N., Adekeye, B.T., 2009. Evaluation of the methanol extract of Ficus exasperata stem bark, leaves and roots for phytochemical analysis and antimicrobial activities. Afr. J. Plant Sci. 3(12), 283-287.

Akah, P.A., Orisakwe, O.E., Gamaniel, K.S., Shittu, A., 1998. Evaluation of Nigerian traditional medicines: II. Effects of some Nigerian folk remedies on peptic ulcer. J. Ethnopharmacol. 62(2), 123-127.

Amponsah, I.K., Fleischer, T.C., Dickson, R.A., Annan, K., Thoss, V., 2013. Evaluation of antiinflammatory and antioxidant activity of Furanocoumarins and Sterolin from the stem bark of Ficus exasperata Vahl. (Moraceae). J. Sci. Innov. Res. 2(5), 880-887.

Bafor, E.E., Lim, C.V., Rowan, E.G., Edrada-Ebel, R.A., 2013. The leaves of Ficus exasperata Vahl (Moraceae) generates uterine active chemical constituents. J. Ethnopharmacol. 145, 803-812.

Berg, C.C., Wiebes, J.T., “African Fig Trees and Fig Wasps, 1992” Koninklijke Nederlandse Akademie van Wetenschappen, Amsterdam, , p 1-298.

Bianchi, G., Pozzi, N., Vlahov, G., 1994. Pentacyclic triterpene acids in olives. Phytochemistry 37(1), 205-207.Carmichael, J., DeGraff, W.G., Gazdar, A.F., Minna, J.D., Mitchell, J.B., 1987. Evaluation of a tetrazolium-based semiautomated colorimetric assay: Assessment of chemosensitivity testing. Cancer Res. 47, 936-942.

Chandramu, C., Manohar, R.D., Krupadanam, D.G.L., Dashavantha, R.V., 2003. Isolation, characterization and biological activity of betulinic acid and ursolic acid from Vitex negundo L. Phytother. Res. 17(2), 129-134.

Chudzik, M., Korzonek-Szlacheta, I., Król, W., 2015. Triterpenes as potentially cytotoxic compounds. Molecules 20, 1610-1625.

Feusso, H.M.F., Mvot Akak, C., Tala, M.F., Azebaze, A.G.B., Tsabang, N., Vardamides, J.C., Laatsch, H., 2016. Conocarpol, a new cycloartane triterpenoid from Diospyros conocarpa. Z. Naturforsch. 71, 935-940.

Focho, D.A., Ndam, W.T., Fonge, B.A., 2009. Medicinal plants of Aguambu-Bamumbu in the Lebialem highlands, southwest province of Cameroon. Afr. J. Pharm. Pharmacol. 3, 1-13.

Govindarajan, R., Rastogi, S., Vijayakumar, M., Shirwaikar, A., Rawat, A.K., Mehrotra, S., Pushpangadan, P., 2003. Studies on the antioxidant activities of Desmodium gangeticum. Biol. Pharm. Bull. 26(10), 1424-1427.

Habib, R., Nikkon, F., Rahman, M., Haque, E., Karim, R., 2007. Isolation of stigmasterol and β-sitosterol from methanolic extract of root bark of Calotropis gigantean (Linn). Biotechnol. J. Int. 10(22), 4174-4176.

Ijeh, I.I., Ukweni, A.I.J., 2007. Acute effect of administration of ethanol extracts of Ficus exasperata vahl on kidney function in albino rats. J. Med. Plants Res. 1, 27-29.

Jiofack, D.M.D., Lallemand, M.C., Kuete, V., Mbazoa, C.D., Wansi, J.D., Trinh-van-Dufat, H., Michel, S., Wandji, J., 2012. A new sphingolipid and furanocoumarins with antimicrobial activity from Ficus exasperata. Chem. Pharm. Bull. 60(8), 1072-1075.

Mbeunkeu, A.B.D., Azebaze, A.G.B., Tala, M.F., Teinkela, J.E.M., Noundou, X.S., Krause, R.W.M., Vardamides, J.C., Laatsch, H., 2018. Three new pentacyclic triterpenoids from twigs of Manniophyton fulvum (Euphorbiaceae). Phytochem. Lett. 27, 1-8.

Mo, E.J., Ahn, J.H., Jo, Y.H., Kim, S.B., Hwang B.Y., Lee, M.K., 2017. Inositol derivatives and phenolic compounds from the roots of Taraxacum coreanum. Molecules 22(8), 1349.

Mohammadhosseini, M., Sarker, S.D., Akbarzade, A., 2017. Chemical composition of the essential oils and extracts of Achillea species and their biological activities: A review. J. Ethnopharmacol. 199, 350-394.

Monteiro, V. de F.F., Mathias, L., Vieira, I.J.C., Schripsema, J.R., Braz-Filho, 2002. Prenylated coumarins, chalcone and new cinnamic acid and dihydrocinnamic acid derivatives from Brosimum gaudichaudii. J. Braz. Chem. Soc. 13(2), 281-287.

Mouho, D.G., Oliveira, A.P., Kodjo, C.G., Valentão, P., Gil-Izquierdo, A., Andrade, P.B., Ouattara, Z.A., Bekro, Y.A., Ferreres, F., 2018. Chemical findings and in vitro biological studies to uphold the use of Ficus exasperata Vahl leaf and stem bark. Food Chem. Toxicol. 112, 134-144.

Nnamonu, L.A., Tor-Anyiin, T.A., Ugbenyo, N.O., Anyam, J.V., 2016. Isolation and characterization of α-amyrin from stem bark of Ficus exasperata (Vahl). Biotechnol. J. Int. 16(4), 1-7.

Noumi, E., Yomi, A., 2001. Medicinal plants used for intestinal diseases in Mbalmayo Region, Central Province, Cameroon. Fitoterapia 72, 246-254.

Odunbaku, O.A., Ilusanya, O.A., and Akasoro, K.S., 2008. Antibacterial activity of ethanolic leaf extract of Ficus exasperata on Escherichia coli and Staphylococcus albus. Sci. Res. Essays 3 (11), 562-564.

Sirisha, N., Sreenivasulu, M., Sangeeta, K., Madhusudhana, C.C., 2010. Antioxydant properties of Ficus species - A review. Int. J. PharmTech Res. 2(4), 2174-2182.

Titanji, V.P., Zofou, D., Ngemenya, M.N., 2008. The antimalarial potential of medicinal plants used for the treatment of malaria in Cameroonian folk medicine. Afr. J. Tradit. Complement. Altern. Med. 5, 302-321.

Wansi, J.D., Sewald, N., Nahar, L., Martin, C., Sarker, S.D., 2018. Bioactive essential oils from the Cameroonian rain forest: A review - Part I. Trends Phytochem. Res. 2(4), 187-234.

Wansi, J.D., Sewald, N., Nahar, L., Martin, C., Sarker, S.D., 2019. Bioactive essential oils from the Cameroonian rain forest: A review - Part II. Trends Phytochem. Res. 3(1), 3-52.

Woode, E., Poku, R.A., Ainooson, G.K., Boakye-Gyasi, E., Abotsi, W.K.M., Mensah, T.L., 2009. An evaluation of the anti-inflammatory, antipyretic and antinociceptive effects of Ficus exasperata (Vahl) leaf extract. J. Pharmacol. Toxicol. 4(4), 135-151.