Ficusanol, a new cinnamic acid derivative and other constituents from the roots of Ficus exasperata Vahl. (Moraceae) with antioxidant and cytotoxic activities

محورهای موضوعی : Phytochemistry: Isolation, Purification, Characterization

Stevine Claudiale Popwo Tameye ¹ , Jean Claude Ndom ² , Edwige Laure Nguemfo ³ , Jean Duplex Wansi ⁴ , Juliette Catherine Vardamides ⁵ , Anatole Guy Blaise Azebaze ⁶

1 - Analytical, Structural and Materials Chemistry Laboratory, Department of Chemistry, Faculty of Sciences, University of Douala. P.O. Box 24157 Douala, Cameroon
2 - Analytical, Structural and Materials Chemistry Laboratory, Department of Chemistry, Faculty of Sciences, University of Douala. P.O. Box 24157 Douala, Cameroon
3 - Département des Sciences Biologiques, Faculté de Médecine et des Sciences Pharmaceutiques (FMSP), Université de Douala, BP 2701 Douala, Cameroun
4 - Analytical, Structural and Materials Chemistry Laboratory, Department of Chemistry, Faculty of Sciences, University of Douala. P.O. Box 24157 Douala, Cameroon
5 - Analytical, Structural and Materials Chemistry Laboratory, Department of Chemistry, Faculty of Sciences, University of Douala. P.O. Box 24157 Douala, Cameroon
6 - Analytical, Structural and Materials Chemistry Laboratory, Department of Chemistry, Faculty of Sciences, University of Douala. P.O. Box 24157 Douala, Cameroon

تاریخ دریافت : 1398/04/27 تاریخ پذیرش : 1398/10/30 تاریخ انتشار : 1398/12/11

کلید واژه: cytotoxic activity, antioxidant activity, <i>Ficus exasperate</i>, phytochemical analysis, Moraceae, Spectroscopic techniques, ficusanol,

چکیده مقاله :

Phytochemical investigation of the roots of Ficus exasperata Vahl. (Moraceae) led to the isolation of a new cinnamic acid derivative, named ficusanol (1) along with eleven known compounds: 3-(6-methoxybenzo[b]furan-5-yl)propenoic acid (2), bergapten (3), oxypeucedanin hydrate (4), marmesin (5), decursinol (6), aridanin (7), betulinic acid (8), maslinic acid (9), a mixture of stigmasterol (10) and β-sitosterol (11), and sitosteryl-3-O-β-D-glucopyranoside (12). The structures of the new compound as well as those of the known ones were established by the means of usual spectroscopic methods: NMR (1H, 13C, DEPT, COSY, HSQC and HMBC) data and HR-ESIMS data. Crude extract and compounds 1, 2, 5, 6 and 7 were evaluated for their radical scavenging potency using DPPH (2,2-diphenyl-1-picrylhydrazyl) assay. Accordingly, the compound 6 showed significant antioxidant activity with IC50 = 25.10 ± 0.91 µg/mL, whereas the other compounds showed only moderate activity at high concentrations. Compounds 2, 6 and 7 were also evaluated for their cytotoxic activity among which the compound 7 exhibited a strong cytotoxic activity with a viability percentage of 3.5% on mouse lymphoma cell line L5178Y.

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