The effect of caloric restriction on reserpine-induced catalepsy in rats model of Parkinson's disease

Subject Areas : zoology

Azam Khalaj ¹ , Tahreh sadat Shobeiri ² , Mohammad Reza Yazdian ³

1 - Department of Physiology, faculty of science, qom Branch, Islamic Azad University, qom, Iran
2 - Department of Physiology, faculty of science, qom Branch, Islamic Azad University, qom, Iran
3 - Department of medicine, faculty of science, qom branch, Islamic azad university, qom, Iran

Received: 2017-05-26 Accepted : 2018-08-19 Published : 2018-11-22

Keywords: catalepsy, Parkinson&#039, s disease, caloric restriction, Rat,

Abstract :

Aim and Background: Parkinson's disease is the second most common neurodegenerative disorder after Alzheimer's disease and the most common cause of disability . it is a progressive disease that is associated with the destruction of nerve cells. Caloric restriction is the only preventive action that has a life long-lasting effect on laboratory models. It has been shown in a large scale of laboratory animals that caloric restriction increases life expectancy, decreases the incidence of several age-related diseases, and preserves youth activities. Therefore, the aim of this study was to investigate the effect of caloric restriction diet on reserpine-induced catalepsy in male rats model of Parkinson's disease. Material and Methods: In this study, 30 Wistar rats were divided in 5 groups (control, Parkinson's disease,caloric restriction, Parkinson's disease + caloric restriction, caloric restriction+ Parkinson's disease(2) ).Animals in caloric restriction groups were under the caloric restriction of 30 percent. Parkinson's disease was induced by administration of Reserpine (1 mg/kg, i.p). The bar- test was used to measure cataleptic symptoms. Results: catalepsy was significantly lower in of caloric restriction + Parkinson's disease and caloric restriction+ Parkinson's disease (2) groups than in Parkinson's disease group. (P <0/05). Conclusion: caloric restriction of 30 percent can improve reserpine-induced catalepsy in male rats model of Parkinson's disease. Also, caloric restriction before inducing Parkinson's disease reduces the severity of complications after getting sick, including catalepsy.