The anticancer and antibacterial properties of Zingiber officinale (ginger) extracts on cell viability of Cancer cells(AGS) and some Pathogenic bacteria

Subject Areas : Microbiology

Fatemeh Abdollahi ¹ (Department of Microbiology, Faculty of Sciences , , Shahrekord Branch, Islamic Azad University, Shahrekord, I.R. Iran)
Faranak Aali ² (Biotechnology Research Center, Shahrekord Branch, Islamic Azad University, Shahrekord, I.R. Iran)
Ali Sharifzadeh ³ (Department of Microbiology, Faculty of Veterinary Medicine, Shahrekord Branch, Islamic Azad University, Shahrekord, I.R. Iran.)

Received: 2021-08-23 Accepted : 2022-01-10 Published : 2022-09-23

Keywords: Antimicrobe, anticancer, Zingiber officinale, Extract,

Abstract :

Introduction: Today Ginger in fresh and dried form is used as a spice around the world.Ginger with a scientific name of Zingiber officinale, is a herbal medicine. It is widely used inthe traditional medicine and utilised as a dietary supplement. The aim of this study is todetermine the antibacterial and anticancer properties and activities of hydroalcoholic extractof ginger.Materials and Methods: The cell lines were grown in RPMI supplemented with 10% FBS,1% penicillin and streptomycin. The cells were allowed to incubate at 37ºC in an atmospherethat contained 5% CO2 and 95% humidity. The extracts were also used with MIC onKlebciella Pneumoniae, E. Coli, Pseudomonas aeroginosa and Staphylococcus aureus. Thestandard MTT assay was performed to estimate cell viability after treatment by Zingiberextracts. We examined cytotoxicity effects of different concentrations the (250, 500, 750,1000, 1250, 1500, 1750, 2000, 1250, 2500, 2750 μg/ml) of Zingiber extracts on AGS celllines were examined.Results: Based on the findings of this Study, these extracts at different concentrations hadinhibitory effect on Klebciella Pneumoniae, E.Coli, and Staphylococcus aureus. Also Theresults of the MTT assay showed that the Zingiber extracts based on time and concentrationhad anticancer activities.Conclusion: Based on our results and findings it might be suggested that ginger extract withoptimum concentrations might be employed in food formulations to inhibit pathogenicbacteria and cancer cell lines.

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