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      • Open Access Article

        1 - The anticancer and antibacterial properties of Zingiber officinale (ginger) extracts on cell viability of Cancer cells(AGS) and some Pathogenic bacteria
        Fatemeh Abdollahi Faranak Aali Ali Sharifzadeh
        Introduction: Today Ginger in fresh and dried form is used as a spice around the world.Ginger with a scientific name of Zingiber officinale, is a herbal medicine. It is widely used inthe traditional medicine and utilised as a dietary supplement. The aim of this study is More
        Introduction: Today Ginger in fresh and dried form is used as a spice around the world.Ginger with a scientific name of Zingiber officinale, is a herbal medicine. It is widely used inthe traditional medicine and utilised as a dietary supplement. The aim of this study is todetermine the antibacterial and anticancer properties and activities of hydroalcoholic extractof ginger.Materials and Methods: The cell lines were grown in RPMI supplemented with 10% FBS,1% penicillin and streptomycin. The cells were allowed to incubate at 37ºC in an atmospherethat contained 5% CO2 and 95% humidity. The extracts were also used with MIC onKlebciella Pneumoniae, E. Coli, Pseudomonas aeroginosa and Staphylococcus aureus. Thestandard MTT assay was performed to estimate cell viability after treatment by Zingiberextracts. We examined cytotoxicity effects of different concentrations the (250, 500, 750,1000, 1250, 1500, 1750, 2000, 1250, 2500, 2750 μg/ml) of Zingiber extracts on AGS celllines were examined.Results: Based on the findings of this Study, these extracts at different concentrations hadinhibitory effect on Klebciella Pneumoniae, E.Coli, and Staphylococcus aureus. Also Theresults of the MTT assay showed that the Zingiber extracts based on time and concentrationhad anticancer activities.Conclusion: Based on our results and findings it might be suggested that ginger extract withoptimum concentrations might be employed in food formulations to inhibit pathogenicbacteria and cancer cell lines. Manuscript profile
      • Open Access Article

        2 - Optimization of extraction methods for total polyphenolic compounds obtained from rhizomes of Zingiber officinale
        Lida Eberle Alena Kobernik Aleksandra Aleksandrova Iryna Kravchenko
      • Open Access Article

        3 - Effect of optimized nanocapsule containing Zingiber officinale based on gum arabic and gelatin as a natural polymeric wall on adult insect and larvae of Tribolium confusum
        A. R. Jalalizand M. Shahnazari M. Mirmohammadsadeghi
        Wheat is a strategic crop and is mainly consumed for the production of bread which is considered to be one of the most consumed crops in the world. Wheat is the most important plant on earth and is highly adapted to different climates. Flour (Tribolium confusum) in Iran More
        Wheat is a strategic crop and is mainly consumed for the production of bread which is considered to be one of the most consumed crops in the world. Wheat is the most important plant on earth and is highly adapted to different climates. Flour (Tribolium confusum) in Iran is found in all non-health warehouses, mills and bakeries. This type of insect is common in most parts of the world. Its main origin is probably India. Different chemical compounds have been used to protect warehouse products from pest attack. But in general, the use of these compounds has led to serious and growing problems, such as the poisoning of parasitoids, predators, pollinators, fish and humans, and possibly their mortality. Therefore, in the present study, the efficiency of ginger nano-capsule with Tribolium confusum polymeric wall as a nutritional indicator of weevil flour was evaluated. The results showed that the use of nanocapsules containing Zingiber officinale oil as an insecticide in different treatments had effective results and 100% of Tribolium confusummortality. Manuscript profile
      • Open Access Article

        4 - A Remedy for Biodeterioration: Zingiber officinale Roscoe. Oil
        Neeta Sharma Richa Tiwari Madhu Prakash Srivastava
        In our study, bioactivity of essential oil extracted from Ginger (Zingiber officinaleRoscoe.) that belongs to family Zingiberaceae was analyzed. Ginger rhizome oil was found to be effective against a range of bio-deteriogens. The Minimum Inhibitory Concentration (MIC) v More
        In our study, bioactivity of essential oil extracted from Ginger (Zingiber officinaleRoscoe.) that belongs to family Zingiberaceae was analyzed. Ginger rhizome oil was found to be effective against a range of bio-deteriogens. The Minimum Inhibitory Concentration (MIC) value was determined by Poisoned Food Technique and Volatile Activity Assay. The study demonstrates that essential oil had a wide spectrum of antifungal activities against common biodeteriogens Aspergillus niger van Tiegh., Penicillium chrysogenum Thom., Alternaria alternate (Fr.) Keissl and Fusarium roseum Link. Minimum inhibitory concentration (MIC) of oil was found to be effective, showing results at 1.0mL/cm-3of oil in respect to all fungi. At higher concentration of 2.0 mL/cm-3 of oil was fungicidal in action.2.0 mL/cm-3 was proved appropriate concentration for commercial trial of ginger oil as preservative for stored pulses and nuts which were used as test commodities. Manuscript profile
      • Open Access Article

        5 - Molecular evaluation of sea enterotoxin gene expression in Staphylococcus aures treated with Ginkgo biloba and Zingiber officinale plant extracts
        Shideh Masoumi Hadi Habibollahi Mohammad Reza Safari Motlagh
        In this study, the antimicrobial effect of extracts of Ginkgo biloba and Zingiber officinale plants against Staphylococcus aureus and their effect on the expression of sea enterotoxin gene were investigated. Two standard and pathogenic strains of S. aureus with enteroto More
        In this study, the antimicrobial effect of extracts of Ginkgo biloba and Zingiber officinale plants against Staphylococcus aureus and their effect on the expression of sea enterotoxin gene were investigated. Two standard and pathogenic strains of S. aureus with enterotoxin sea gene and G. biloba and Z. officinale extracts were used as ready-made tablets with a specified concentration. Antimicrobial test of the extracts was performed by disk impregnation and then the minimum inhibitory and bacteriocidal concentrations of these extracts were evaluated by MIC and MBC tests and SubMIC concentration of these extracts was used to evaluate the effect of extract treatment on the expression of sea enterotoxin gene. Then RNA extraction and cDNA synthesis and finally Real time PCR were performed and the results were interpreted. The results of disk diffusion and MIC showed that Z. officinale extract has antimicrobial effect. Interpretation of Real time PCR results also showed that Z. officinale extract reduced and completely inhibited the expression of sea enterotoxin gene in standard strain ATCC 25923. This extract also significantly reduced the expression of the target gene in the pathogenic strain, and its expression was reduced to 4% compared to the untreated sample. On the contrary, G. biloba extract significantly increased sea gene expression. This extract increased the expression of the target gene in the standard strain and the pathogen by approximately 55 and 9 fold, respectively. According to the results of this study, ginger can be a good candidate to fight S. aureus infections. Manuscript profile