Study of the effect of nerolidol on Alzheimer's disease in Wistar rats

Subject Areas : Journal of Comparative Pathobiology

پیمان  Taheri ¹ (Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran)
پریچهره  Yaghmaei ² (Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran)
زهرا  Hajebrahimi ³ (A&S Research Institute, Ministry of Science Research and Technology, Tehran, Iran)
کاظم  Parivar ⁴ (Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran)

Received: 2022-06-21 Accepted : 2022-08-25 Published : 2022-08-25

Keywords: Alzheimer’s, nerolidol, beta amyloid, oxidative stress,

Abstract :

Alzheimer's disease is the most important cause of dementia in human societies and the elderly population. One of the most important symptoms of this disease is amyloid plaques in the hippocampus. Inflammation and oxidative stress play an important role in the development of Alzheimer's disease. Nerolidol is one of the many metabolites of plants and has antioxidant and anti-inflammatory properties. Therefore, the aim of this study was to evaluate the effect of nerolidol on beta amyloid-induced model of Alzheimer's in rats. 48 male Wistar rats randomly divided into 8 groups including control, sham, streptozotocin induced model of Alzheimer's, Alzheimer's and drug solvent, Alzheimer's and treatment with donepezil, Alzheimer's and treatment with nrolidol dose 50, Alzheimer's and treatment with nrolidol dose 100 and protection groups (pre-treatment with nerolidol before Alzheimer's induction). Rats weight, catalase activity, and amount of amyloid plaque were measured. Histological studies were performed by fluorescent staining. Streptozotocin increased amyloid plaques, and decreased rat's weight and catalase activity. Donepezil and nerolidol, especially at doses of 100 and in the protective group, reduced the symptoms of Alzheimer's disease through weight gain, increased catalase activity, and decreased amyloid plaques. These findings show that nerolidol can be effective in improving Alzheimer's disease and its damage, and may possibly be effective in preventing Alzheimer's in people with a family history of Alzheimer's.

References:

1.Nguyen TT, Van Giau V, Vo TK. Current advances in transdermal delivery of drugs for Alzheimer's disease. Indian J Pharmacol. 2017;49(2):145.

2.Alves L, Correia AS, Miguel R, Alegria P, Bugalho P. Alzheimer’s disease: a clinical practice-oriented review. Frontiers in Neurology. 2012 Apr 20;3:63.  2011;377(9770):1019-31.

3.Wu C, Yang L, Li Y, Dong Y, Yang B, Tucker LD, Zong X, Zhang Q. Effects of exercise training on anxious–depressive-like behavior in Alzheimer rat. Medicine and Science in Sports and Exercise. 2020 Jul;52(7):1456.

4. 4. Rajmohan R, Reddy PH. Amyloid-beta and phosphorylated tau accumulations cause abnormalities at synapses of Alzheimer’s disease neurons. Journal of Alzheimer's Disease. 2017 Jan 1;57(4):975-99..


5. 5. Colom LV, Castañeda MT, Bañuelos C, Puras G, García-Hernández A, Hernandez S, Mounsey S, Benavidez J, Lehker C. Medial septal β-amyloid 1-40 injections alter septo-hippocampal anatomy and function. Neurobiology of Aging. 2010 Jan 1;31(1):46-57.


6. 6. Liu PP, Xie Y, Meng XY, Kang JS. History and progress of hypotheses and clinical trials for Alzheimer’s disease. Signal Transduction and Targeted Therapy. 2019 Aug 23;4(1):1-22.


7. 7. Silva MV, Loures CD, Alves LC, de Souza LC, Borges KB, Carvalho MD. Alzheimer’s disease: risk factors and potentially protective measures. Journal of Biomedical Science. 2019 Dec;26(1):1-1.


8. 8. Tsuda L, Lim YM. Alzheimer’s disease model system using Drosophila. Drosophila Models for Human Diseases. 2018:25-40.


9. 9. Müller M, Cheung KH, Foskett JK. Enhanced ROS generation mediated by Alzheimer's disease presenilin regulation of InsP3R Ca2+ signaling. Antioxidants & Redox Signaling. 2011 Apr 1;14(7):1225-35.


10. 10. Behl C. Oxidative stress in Alzheimer’s disease: implications for prevention and therapy. Alzheimer’s Disease. 2005:65-78.

11Pacifico S, D'Abrosca B, Golino A, Mastellone C, Piccolella S, Fiorentino A, Monaco P. Antioxidant evaluation of polyhydroxylated nerolidols from redroot pigweed (Amaranthus retroflexus) leaves. LWT-Food Science and Technology. 2008 Nov 1;41(9):1665-71.

12. 12. Silva MP, Oliveira GL, De Carvalho RB, De Sousa DP, Freitas RM, Pinto PL, de Moraes J. Antischistosomal activity of the terpene nerolidol. Molecules. 2014 Mar 24;19(3):3793-803.


13. 13. Nogueira Neto JD, de Almeida AA, da Silva Oliveira J, Dos Santos PS, de Sousa DP, de Freitas RM. Antioxidant effects of nerolidol in mice hippocampus after open field test. Neurochemical Research. 2013 Sep;38(9):1861-70.


14. 14. De Carvalho RB, De Almeida AA, Campelo NB, Lellis DR, Nunes LC. Nerolidol and its pharmacological application in treating neurodegenerative diseases: a review. Recent Patents on Biotechnology. 2018 Sep 1;12(3):158-68.


15. 15. Francis PT, Parsons CG, Jones RW. Rationale for combining glutamatergic and cholinergic approaches in the symptomatic treatment of Alzheimer’s disease. Expert Review of Neurotherapeutics. 2012 Nov 1;12(11):1351-65.


16. 16. Liu L, Drouet V, Wu JW, Witter MP, Small SA, Clelland C, Duff K. Trans-synaptic spread of tau pathology in vivo. PloS one. 2012 Feb 1;7(2):e31302..


17. 17. Cheng YF, Wang C, Lin HB, Li YF, Huang Y, Xu JP, Zhang HT. Inhibition of phosphodiesterase-4 reverses memory deficits produced by Aβ25–35 or Aβ1–40 peptide in rats. Psychopharmacology. 2010 Oct;212(2):181-91.


18. 18. Peng D, Pan X, Cui J, Ren Y, Zhang J. Hyperphosphorylation of tau protein in hippocampus of central insulin-resistant rats is associated with cognitive impairment. Cellular Physiology and Biochemistry. 2013;32(5):1417-25.

19. 19. Javed H, Azimullah S, Abul Khair SB, Ojha S, Haque ME. Neuroprotective effect of nerolidol against neuroinflammation and oxidative stress induced by rotenone. BMC Neuroscience. 2016 Dec;17(1):1-2.