anticancer

حرية الوصول المقاله

1 - Theoretical Study of Drug Delivery Ability of Carbon INanotube
N. Dalill Mansour K. Zare A Elsagh

Nowadays apphcanon of nanotubes in biology and medicinal science is more investigated. Nanotubes can passthroueh cell walls and transport and release drugs in special tissues. The purpose of this paper is to investigatethe interaction of a nanotube having hydroxyl funct أکثر

Nowadays apphcanon of nanotubes in biology and medicinal science is more investigated. Nanotubes can passthroueh cell walls and transport and release drugs in special tissues. The purpose of this paper is to investigatethe interaction of a nanotube having hydroxyl functional groups (OH) with an anticancer agent. In this worktransporting of an anticancer drug named 2-(2-amino 6,7-dimethyl Pteridine 4-ylammo)-ethanol by a zigzagnanotube with 60 C atoms (5,0) is investigated. The methods used are quantum mechanics and seroiemphical.Two composites of the drug and nanotube are under studying: I-compose of drug and nanotubes wall 2-compose of drug and one of the two heads of nanombe. At first some hydroxylic functional groups are put onthe head of nanotube and then an etheric bond formed between agents. The results show that the composite ismore stable than the single agent. Also binding of drug with the head of the nanotube is more stable than thewall. In the other case the Interaction between a carbon nanotube (9,0) and Levothyroxine as a drug isinvestigated. All of above composites art investigated by semiempincal methods and MolecularMechanicsiMolecular Ilymunics simulation in body temperature (310 K) and their heat capacities are obtainedin water, methanol and ethanol solutions separately. The results show that by increasing initial temperature inmost of the cases heat capacity increase& Also it can be seen that by increasing of solvent molecular mass, theheat capacity increases too. تفاصيل المقالة

حرية الوصول المقاله

2 - سنجش اثرات ضدسرطانی و ضدمیکروبی عصاره های زنجبیل بر رده سلول های سرطانی معده ( AGS)و برخی باکتریهای پاتوژن
فاطمه عبداللهی فرانک عالی علی شریف زاده

10.30495/jftn.2022.62726.11149

زنجبیل با نام علمی Zingiber officinale از جمله گیاهان دارویی است که در طب سنتی مطرح بوده و از دیرباز به عنوان مکمل غذایی کاربرد فراوانی داشته است . هدف از این بررسی سنجش اثر ضدمیکروبی عصار ه های آبی و هیدروالکلی زنجبیل بر برخی از باکتری های بیماریزا و اثر سمیت سلولی زنج أکثر

زنجبیل با نام علمی Zingiber officinale از جمله گیاهان دارویی است که در طب سنتی مطرح بوده و از دیرباز به عنوان مکمل غذایی کاربرد فراوانی داشته است . هدف از این بررسی سنجش اثر ضدمیکروبی عصار ه های آبی و هیدروالکلی زنجبیل بر برخی از باکتری های بیماریزا و اثر سمیت سلولی زنجبیل بر رده سلولی سرطان معده (AGS) بود.ابتدا عصاره های آبی و هیدروالکلی استخراج و سپس سوسپانسیون های میکروبی تهیه و استاندارد گردید . رده سلولهای سرطانی معده نیز در محیط ،کشت گردید . رطوبت قرار گرفت. اثر ضدمیکروبی عصاره ها به روش میکرو براث دایلوشن آزمونMIC سنجش گردید . از روش استانداردMTT نیز برای برآورد توانایی زیستی سلول های سرطانی AGS در مجاورت عصاره آبی زنجبیل در غلظت های 750، 1250، 1750 و 2250 میکروگرم در هر میلی لیتر در مدت زمان های 24، 48 و 72 ساعت بهره گرفته شد . بر اساس یافته های این تحقیق ، عصاره هیدروالکلی زنجبیل توانست رشد باکتری های استافیلوکوکوس اورئوس، کلبسیلا پنومونیه و اشریشیا کلای مورد آزمایش را مهار نماید . بیشترین مقدارMIC ، برای باکتری E.Coli 31/0گرم بر میلی لیتر ، برای باکتری کلبسیلا پنومونیه 28/0 گرم بر میلی لیتر و برای باکتری استافیلوکوکوس اورئوس 29/0 گرم برمیلی لیتر بود . همچنین بر اساس نتایج آزمون MTT، عصاره آبی زنجبیل بر حسب غلظت و زمان دارای اثر ضدسرطانی و بیش از 50 درصد کاهش تراکم سلولی بر رده سلولی AGS بود . مقدار IC50 نمونه ها که بیانگر غلظتی از نمونه است که موجب 50 درصد مهار رشد سلولهای سرطانی میشود، 2250 میکروگرم بر میلی لیتر محاسبه شد .با توجه به یافته های این تحقیق می توان پیشنهاد نمود که عصاره آبی زنجبیل با غلظت مناسب قابلیت استفاده به عنوان یک مکمل غذایی مناسب برای مهار رشد برخی سلول های سرطانی را دارا می باشد. تفاصيل المقالة

حرية الوصول المقاله

3 - The Use of Nanoemulsion-based Strategies to Improve Corrosion inhibition Efficiency of Herbal Extract Inhibitors
Meysam Ahmadi-Zeidabadi Razieh Razavi Mahnaz Amiri Seyed Hamzeh Hosseini Maryam Payandeh

The requirement for abiding by strict environmental protection regulations has caused many researchers during the past decades to go after using green and cheap compounds available from renewable sources like plant metabolites (bioactive compounds). Improving the corros أکثر

The requirement for abiding by strict environmental protection regulations has caused many researchers during the past decades to go after using green and cheap compounds available from renewable sources like plant metabolites (bioactive compounds). Improving the corrosion prevention effect of various plant extracts is of utmost importance in this regard, for which a novel nanoemulsion-based strategy is proposed in the present paper. The corrosion inhibitors that participated in this study included Amaranthus, Althermanthea, and Cionura erecta (L.) Griseb, which was investigated against mild steel in 0.5 mol·L-1 HCl media. The presented data were obtained via electrochemical techniques (EIS andpolarization)and surface analyses (SEM). The researchers also used Dynamic light scattering to evaluate the particles’ sizes in nanoemulsion solutions. Nanoemulsions indicated hydrodynamic diameter below 500 nm, meanwhile having narrow particle size distribution.Findings presented that 100 mg/L of Amaranthus extract nanoemulsion resulted in an inhibition efficiency of 91%, denoting that a slight amount of Amaranthus inhibitor extract could produce greater efficiency. The SEM analysis results were decisive in proving that the absorption of Amaranthus molecules on the surface of metal decreased its dissolution rate substantially, producing a smooth and clean surface. One primary reason for the effective adsorption of extracts on metal surfaces via chelation with iron atoms refers to the presence of an abundant number of electron donor Oxygen- based atoms in the molecules of different aerial parts of the extracts. Further description for the extract inhibitory mechanism is the physical adsorption of the section on the surface layer of metal followed by the Langmuir adsorption isotherm. The nanoemulsion Amaranthus extract in this process absorbs approx. -24.7 kJ·mol-1 of free energy. the cytotoxicity test through MTT assay on A172 and SHSY5Y cell lines was used, revealing the therapeutic impact on initiating cytotoxic response in neural cell lines, and anticancer activity. تفاصيل المقالة

حرية الوصول المقاله

4 - The anti-inflammatory and antitumor potential of <i>Cryptocarya concinna</i> Hance and its phytoconsituents
Christian Bailly Gerard Vergoten

10.30495/tpr.2022.1970912.1283

The tree Cryptocarya concinna Hance is largely distributed in southeast Asia and essentially used for its robust wood. Alcoholic extracts made from the leaves or roots of the plant have revealed anti-inflammatory and anticancer properties. The DNA-damaging dihydrochalco أکثر

The tree Cryptocarya concinna Hance is largely distributed in southeast Asia and essentially used for its robust wood. Alcoholic extracts made from the leaves or roots of the plant have revealed anti-inflammatory and anticancer properties. The DNA-damaging dihydrochalcone derivative cryptocaryone accounts for the anti-proliferative and pro-apoptotic activities observed with the extracts. Other bioactive products have been isolated, including α-pyrone derivatives such as cryptoconcatones A-L and flavonoids such as cryptoconones A-E. A structural analogy is underlined between cryptoconcatone D and two known compounds with an α,β-unsaturated δ-lactone: pironetin and the styryl-lactone goniothalamin which targets the peroxisomal protein MFE2 (multifunctional enzyme type2). Pironetin is a potent α-tubulin binder with robust anticancer properties. By analogy, the binding of cryptoconcatone D to the pironetin-site of α-tubulin is proposed. The review shed light on the phytochemical constituents of Cryptocarya concinna and the biological properties of α,β-unsaturated lactone compounds isolated from this little studied plant. تفاصيل المقالة

حرية الوصول المقاله

5 - A review on biosynthesis, regulation, and applications of terpenes and terpenoids
Anjali Singh Dhananjay Singh Sapna Sharma Nishu Mittal

10.30495/tpr.2023.1989410.1358

Essential oils (EOs) are concentrated liquids extracted from various parts of plants and can be classified based on their phytochemical compounds. Terpenes and terpenoids have a wide range of biological activities, including anticancer, anti-inflammatory, antimicrobial, أکثر

Essential oils (EOs) are concentrated liquids extracted from various parts of plants and can be classified based on their phytochemical compounds. Terpenes and terpenoids have a wide range of biological activities, including anticancer, anti-inflammatory, antimicrobial, antioxidant, and antiallergic properties. Terpenes are plant-based compounds commonly used in the pharmaceutical, food, biofuel, and chemical industries by humans. In synthetic biology, genomic resources and emerging tools facilitate the production of high-quality terpenoids in plants and microbes. Terpenoids, however, are difficult to produce in large quantities due to their complex chemical structures and the limited amounts found in plants. The regulation of terpenoid biosynthesis has gradually emerged as a research priority. This review presents an overview of the biological activities, synthesis pathways, and key enzymes involved in the biosynthetic pathways and regulation of terpenes or terpenoids. This review will also include references for further research on molecular regulation, biological advancements, and increasing the content of terpenes or terpenoids in plants. تفاصيل المقالة

حرية الوصول المقاله

6 - Uranyle Complexes: synthesis, evaluation of biological activity
Shahriar Ghammamy Rozita Hosseinzadeh Khezri Zahra Amini Monir Al-sadat Mirrahimi Masoud Soleimani Saeid Kaviani

In this research, some of the inorganic complexes of uranyl with N- donor ligandswere synthesized. Complexes were characteriezed by FT-IR and UV spectra, ¹HNMR,¹³CNMR and some physical properties. The uranyl unit (UO2) is composed of a center ofuranium at أکثر

In this research, some of the inorganic complexes of uranyl with N- donor ligandswere synthesized. Complexes were characteriezed by FT-IR and UV spectra, ¹HNMR,¹³CNMR and some physical properties. The uranyl unit (UO2) is composed of a center ofuranium atom with the charge (+6) and two oxygen atom by forming two U=O double bonds.The structure is linear (O=U=O, 180) and usually stable. So other ligands often coordinate tothe U atom in the plane perpendicularly to the O=U=O axis. The antitumor activity of some ofligand and their complexes against a panel of human tumor cell lines (HT29: Haman colonadenocarcinoma cell line T47D: human breast adenocarcinoma cell line) were determined byMTT(3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide) assay. These datasuggest that some of these compounds provide good models for the further design of potentantitumor compounds. تفاصيل المقالة

حرية الوصول المقاله

7 - Synthesis of imidazo[2,1-b]thiazole-3-carboxylate through the reaction of thiohydantoins and ethylbromopyruvate
Nasimeh Zarei Mohammad Mehdi Ghanbari Marzieh Jamali Mahboobeh Kiamarsi Pegah Mohagheghzadeh

Imidazo[2,1-b]thiazoles are obtaind in excellent yields from the addition reaction between thiohydantoin and ethylbromopyruvate. These imidazo[2,1-b]thiazoles in the presence of p-TSA in boiling toluene refluxed for 2.5 hours led to imidazo[2,1-b]thiazole-3-carboxylates أکثر

Imidazo[2,1-b]thiazoles are obtaind in excellent yields from the addition reaction between thiohydantoin and ethylbromopyruvate. These imidazo[2,1-b]thiazoles in the presence of p-TSA in boiling toluene refluxed for 2.5 hours led to imidazo[2,1-b]thiazole-3-carboxylates in elimination reactions تفاصيل المقالة

حرية الوصول المقاله

8 - reaction of thiohydantoins and ethylbromopyruvate for Synthesis of imidazo[2,1-b]thiazole 3-carboxylate
Nasimeh Zarei Mohammad Mehdi Ghanbari Marzieh Jamali Mahboobeh Kiamarsi Pegah Mohagheghzadeh

Imidazo[2,1-b]thiazoles are obtaind in excellent yields from the addition reaction between thiohydantoin and ethylbromopyruvate. These imidazo[2,1-b]thiazoles in the presence of p-TSA in boiling toluene refluxed for 2.5 hours led to imidazo[2,1-b]thiazole-3-carboxylates أکثر

Imidazo[2,1-b]thiazoles are obtaind in excellent yields from the addition reaction between thiohydantoin and ethylbromopyruvate. These imidazo[2,1-b]thiazoles in the presence of p-TSA in boiling toluene refluxed for 2.5 hours led to imidazo[2,1-b]thiazole-3-carboxylates in elimination reactions تفاصيل المقالة

حرية الوصول المقاله

9 - Aloe Vera gel extract and sunlight mediated synthesis of silver nanoparticles with highly effective antibacterial and anticancer activity
Noha Mohamed Hossam Elmasry

10.22034/jna.2020.1884807.1176

In this study, a single-step method for green synthesis of silver nanoparticles using Aloe Vera gel extract and sunlight was investigated. The Aloe Vera gel extract is composed of pectins, lignin, and hemicellulose, which can be used in the reduction of silver ions to p أکثر

In this study, a single-step method for green synthesis of silver nanoparticles using Aloe Vera gel extract and sunlight was investigated. The Aloe Vera gel extract is composed of pectins, lignin, and hemicellulose, which can be used in the reduction of silver ions to produce colloidal silver nanoparticles (AgNPs-AV). The preliminary preparation of silver nanoparticles was observed by an immediate color change to brown. The prepared silver nanoparticles were characterized by transmission electron microscopy, Fourier transform infrared spectroscopy, dynamic light scattering, and zeta potential measurements. Additionally, the cytotoxicity and antimicrobial activity of AgNPs-AV was tested. Results indicated the formation of stable spherical 90±40nm with a strong absorption peak appears between 400 and 500 nm. 28.7 ±0.781% of breast cancer cells survived after incubation with AgNPs-AV invitro for 72 hrs. In addition to AgNPs-AV inhibited the growth of the most important human skin pathogens (candida albicans, Pseudomonas aeruginosa and Staphylococcus aureus). The largest inhibition zone was observed for candida albicans. This method for synthesis is very fast, produces spherical colloidal silver nanoparticles having an excellent antioxidant activity, high anticancer therapeutic index and very promising antibacterial activity. This greenly synthesized nano-formulation has a great potential to be explored in many different aspects. تفاصيل المقالة

حرية الوصول المقاله

10 - Aloe Vera gel extract and sunlight mediated synthesis of silver nanoparticles with highly effective antibacterial and anticancer activity
Noha Mohamed H.M. El-Masry

10.22034/jna.2020.675055

In this study, a single-step method for green synthesis of silver nanoparticles usingAloe Vera gel extract and sunlight was investigated. The Aloe Vera gel extractis composed of pectins, lignin, and hemicellulose, which can be used in thereduction of silver ions to prod أکثر

In this study, a single-step method for green synthesis of silver nanoparticles usingAloe Vera gel extract and sunlight was investigated. The Aloe Vera gel extractis composed of pectins, lignin, and hemicellulose, which can be used in thereduction of silver ions to produce colloidal silver nanoparticles (AgNPs-AV). Thepreliminary preparation of silver nanoparticles was observed by an immediatecolor change to brown. The prepared silver nanoparticles were characterizedby transmission electron microscopy, Fourier transform infrared spectroscopy,dynamic light scattering, and zeta potential measurements. Additionally, thecytotoxicity and antimicrobial activity of AgNPs-AV was tested. Results indicatedthe formation of stable spherical 90±40nm with a strong absorption peak appearsbetween 400 and 500 nm. 28.7 ±0.781% of breast cancer cells survived afterincubation with AgNPs-AV invitro for 72 hrs. In addition to AgNPs-AV inhibitedthe growth of the most important human skin pathogens (candida albicans,Pseudomonas aeruginosa and Staphylococcus aureus). The largest inhibitionzone was observed for candida albicans. This method for synthesis is very fast,produces spherical colloidal silver nanoparticles having an excellent antioxidantactivity, high anticancer therapeutic index and very promising antibacterialactivity. This greenly synthesized nano-formulation has a great potential to beexplored in many different aspects. تفاصيل المقالة

حرية الوصول المقاله

11 - Flavonoids as the emerging therapeutic agents: A review of their bioactivity, chemoprevention and chemotherapy approach
آبیچه ایکالو جامز داماهابیلاب

Background and aim: The aim of the review is to study the bioactivity, chemoprevention and chemotherapy approach of flavonoids as the emerging therapeutic agents. Results: The quickest way of managing health challenges in the developing world is by the uses of herbs. Th أکثر

Background and aim: The aim of the review is to study the bioactivity, chemoprevention and chemotherapy approach of flavonoids as the emerging therapeutic agents. Results: The quickest way of managing health challenges in the developing world is by the uses of herbs. These medicinal plants are known to contain phytochemicals that conferred on them these pharmacological potentials. Among these chemical constituents are the flavonoids which become the emergent therapeutic agents because of their vast pharmacological properties. Among reported activities of plants derived phytochemicals, flavonoids have shown various pharmacological activities. Many flavonoids have shown significant anticancer, antibacterial, antifungal and antioxidant activities. Therefore, researches have focused on developing potent bioactive flavonoids. Recent researchers have focused on the development of potent drugs with minimal toxicity for cancer chemoprevention and chemotherapy. The antibacterial activities of flavonoids against a wide range of microorganisms and their radical-scavenging ability are well known and reported. Therefore, one can conclude that flavonoids have actually become emerging therapeutic agents. Recommended applications/industries: In view of the pharmaceutical properties of various flavonoids such as anticancer, antibacterial, antifungal and antioxidant activities, they could be used in pharmaceutical industries. تفاصيل المقالة

حرية الوصول المقاله

12 - Natural Bioactive Products from an Ornamental- Medicinal Flower (<i>Catharanthus roseus</i> (L.) G. Don) forms Promising Therapeutics: A Critical Review of Natural Product-Based Drug Development
Somashekara Rajashekara Utpal Baro

Catharanthus roseus (L.) G. Don (Apocynaceae) commonly called as “flower of immortality”, “the flower of death”, “violet of the sorcerers” and “an emblem of friendship”. It is a well-known weed to employed for treating var أکثر

Catharanthus roseus (L.) G. Don (Apocynaceae) commonly called as “flower of immortality”, “the flower of death”, “violet of the sorcerers” and “an emblem of friendship”. It is a well-known weed to employed for treating various disorders. The study aims at far-reaching review on phytochemistry, pharmacological activities, ethnopharmacology, characterization, chemical composition, and biological applications of C. roseus plants which aids to provide scientific evidence for the ethnobotanical claims and to identify gaps required to be conducted as a future research requirement. Most of the traditional and systematic uses obtained from the extraction of C. roseus plants were validated by the scientific studies such as antimicrobial activity, anticancer activity, antidiabetic activity, antileukemia activity, antioxidant activity, chemotherapeutic drugs and therapy, wound healing, production of nanoparticles and nanoproducts, etc. Isolated compounds, mainly terpenoid indole alkaloids (TIA) such as ajmalicine, anhydrovinblastine, catharanthine, serpentine, vindoline, vinblastine, vincristine, and vindolinine were confirmed and showed potent activity. This review article explores the phytochemistry, ethnopharmacological, pharmacological and biological activities of C. roseus plants which gives the evidence of a potent and commercial drug which up on further research leads to the most viable drug for variety of treatments. تفاصيل المقالة

حرية الوصول المقاله

13 - تاثیراثرات مهاری عصاره گیاه دارویی عروسک پشت پرده (Physalis alkekengi) بر روی سرطان پروستات ناشی از تزریق DMBA در موش
مریم تیموری فریبا خسروی نژاد

10.30495/jdb.2021.683731

هدف: تا کنون مطالعات گسترده ای از اثرات درمانی گیاهان مختلف بر انواع سرطان صورت گرفته است. هدف از این مطالعه، بررسی اثرات عصاره هیدروالکلی گیاه عروسک پشت پرده(Physalis alkekengi) بر سرطان پروستات ناشی از تزریق داروی سرطان زای 12,7 دی متیل بنزآنتراسن (DMBA)، در موش است.م أکثر

هدف: تا کنون مطالعات گسترده ای از اثرات درمانی گیاهان مختلف بر انواع سرطان صورت گرفته است. هدف از این مطالعه، بررسی اثرات عصاره هیدروالکلی گیاه عروسک پشت پرده(Physalis alkekengi) بر سرطان پروستات ناشی از تزریق داروی سرطان زای 12,7 دی متیل بنزآنتراسن (DMBA)، در موش است.مواد و روش ها: در این پژوهش پس از القای بیهوشی در موش های مورد آزمایش، تزریق مستقیم DMBA به غده پروستات موش های نر انجام شد و پس از گذشت 10 روز، هر 48 ساعت و تا پایان روز بیست و یکم، موش های دریافت کننده دارو، مقادیر متفاوت از عصاره ی عروسک پشت پرده به صورت تزریق درون صفاقی دریافت کردند. در گروه کنترل تزریق درون صفاقی نرمال سالین انجام شد. یافته ها: نشان داد که عصاره عروسک پشت پرده به ویژه در دو غلظت (500 و1000) وزن پروستات را بطور معنی داری کاهش داد. همچنین تغییرات بافت آسیب شناسی در تومورهای پروستات گروه های تحت درمان با عصاره Physalis alkekengi در مقایسه با گروه کنترل مشاهده شد نتیجه گیری: به نظر میرسد که عصاره هیدروالکلی عروسک پشت پرده، رشد غیرطبیعی، ضایعات پیش سرطانی و کارسینوم ناشی از DMBA را در پروستات موش نژاد BALB/c مهار و درمان میکند. تفاصيل المقالة

حرية الوصول المقاله

14 - Synthesis of Hydroxyapatite/Ag/TiO2 Nanotubes and Evaluation of Their Anticancer Activity on Breast Cancer Cell Line MCF-7
Sara Rahimnejad Maryam Bikhof Torbati

10.22034/jchr.2016.544148

In this research, TiO2 nanotubes were synthesized by anodized oxidation method and were covered with a hydroxyapatite-silver nanoparticles using photodeposition and dip coating for loading silver nanoparticles and coated hydroxyapatite (HA). The morphological texture of أکثر

In this research, TiO2 nanotubes were synthesized by anodized oxidation method and were covered with a hydroxyapatite-silver nanoparticles using photodeposition and dip coating for loading silver nanoparticles and coated hydroxyapatite (HA). The morphological texture of TiO2 nanotube and Ag-HA nanoparticles on TiO2 nanotubes surface were studied by field emission scanning electron microscopy (FESEM), energy dispersive X-ray spectroscopy (EDAX analysis) and X-ray diffraction (XRD). The MCF-7 cell lines were treated with concentrations 1, 10 and 100 Âµg/ml of TiO2 nanotubes and HA/Ag/TiO2 nanotube for 24 and 48h. Finally, the cell viability and IC50% were evaluated using MTT assay. The results show that the HA/Ag/TiO2 has more positive effect on enhancing the cell death compare to TiO2 nanotubes and also exerts a time and concentration-dependent inhibition effect on viability of MCF-7 cells تفاصيل المقالة

حرية الوصول المقاله

15 - Anti-proliferative and Cytotoxic Effects of Curcumin in MCF-7 Human Breast Cancer Cells
Hossein Abbaspour Akbar Safipour Afshar

10.22034/jchr.2018.544207

Curcumin is the effective constituents of Curcuma longa, which inhibit the growth of cancer cells. Prevention of breast cancer, as one of the common cancer type with serious health problem, is an area of interest in breast cancer research. In this study, we have evaluat أکثر

Curcumin is the effective constituents of Curcuma longa, which inhibit the growth of cancer cells. Prevention of breast cancer, as one of the common cancer type with serious health problem, is an area of interest in breast cancer research. In this study, we have evaluated the effects of curcumin on the cell proliferation of human breast cancer cell line (MCF-7) compared to non-cancer line (MCF-10A). The cell lines were subjected to increasing doses of curcumin ranging from 0 to 30 Î¼g/ml. Cell viability was quantified by MTT assay. In vitro clonogenic survival assay was performed on MCF-7 cells.Â Curcumin inhibited the growth of malignant cells in a time and dose-dependent manner. Calculated IC50 value for MCF-7 cells in 48 h was 12 Î¼g/ml.Â Overall, 45%â€“70% decrease in colony formation was observed in MCF-7 cells treated by 30-60 Î¼g/ml curcumin respectively. The result of our study confirms the potential cytotoxic effects of curcumin in breast cancer cell line. It could be considered as a potential chemopreventive agent in breast cancer treatment. تفاصيل المقالة

حرية الوصول المقاله

16 - Smirnovia Iranica Whole Herb Extract: Antioxidant, Radical Scavenging, Anti-microbial and Anti-Cancer Effects
Leila Monjazeb Marvdashti Samaneh Arab Marjan Bahraminasab Mina Roustaei Samaneh Souri Mojtaba Heydari Majd Anna Abdolshahi

10.22034/jchr.2022.1943420.1443

In this study, the biological activities of whole herb extract of a medicinal plant named Smirnovia Iranica were investigated. The extraction was performed using Supercritical CO2 and phytochemical compounds, total phenolic content (TPC), total flavonoid content (TFC), أکثر

In this study, the biological activities of whole herb extract of a medicinal plant named Smirnovia Iranica were investigated. The extraction was performed using Supercritical CO2 and phytochemical compounds, total phenolic content (TPC), total flavonoid content (TFC), antioxidant, anti-bacterial, and anti-cancer effect were determined in the extract. Based on the results, high TPC concentration (120.36 mg GAE/100 g FW) and TFC (17.41 mg quercetin/100g FW) were obtained in the extract. Besides, the extract showed significant antioxidant activity (IC50=53.97 µg mL-1). Moreover, the extract showed a notable inhibitory effect againstEscherichia coli(MIC=15.63 mg mL-1) andSalmonella enterica (MIC=31.25 mg mL-1). On the other hand, this extract showed the cytotoxic effect on glioblastoma cancer cell lines in the MTT assay. This is the first, yet comprehensive, scientific report about the chemical composition and pharmacological properties of the extract of Smirnovia Iranica whole herb. According to current results, the Smirnovia Iranica extract has excellent antioxidant properties for application as bioactive components for various objects such as as food supplements. The experiment confirmed the efficacy of the extracts as natural antimicrobials and suggested the possibility of employing them in drugs for the treatment of infectious diseases caused by the test organisms. تفاصيل المقالة

حرية الوصول المقاله

17 - Synthesis and Cytotoxic Evaluation of 2-Pyrazoline Derivative on Leukemia Cancer Cell Line K562
Masoud Shaabanzadeh Maryam Bikhof Torbati

10.22034/jchr.2018.545324

The 2-pyrazoline derivatives have a wide range of biological effects, such as anti-viral, anti-bacterial, anti-fungal, anti-depressant and anti-cancer effects. Studies have shown that compounds containing 2-pyrazoline along with another heterocycles may show more effect أکثر

The 2-pyrazoline derivatives have a wide range of biological effects, such as anti-viral, anti-bacterial, anti-fungal, anti-depressant and anti-cancer effects. Studies have shown that compounds containing 2-pyrazoline along with another heterocycles may show more effective biological properties. In this study, a 2-pyrazoline derivative with a spiro-indenoquinoxaline ring at C3 position was synthesized by one-pot microwave-assisted method and its chemical structure was confirmed by 1H NMR spectroscopy. The cytotoxic effects of the compound were evaluated on the K562 cell line and phytohemagglutinin-activated peripheral bloodmononuclear cells (PHA+PBMC) by MTT assay.Additionally, the cytotoxic effects of cisplatin on these cells were investigated and compared with those of 2-pyrazoline. The IC50 values obtained from the 2-pyrazoline derivative effects on the K562 cell line and PHA+PBMC cells were 45 and 55 μg/mL respectively, while cisplatin inhibited proliferation of the same cells with IC50 value 1.71 and 7.8 µg/mL respectively. The results of this study showed that the synthesized derivative had a cytotoxic activity on the K562 cancer cell line at higher concentrations than cisplatin. تفاصيل المقالة

حرية الوصول المقاله

18 - بررسی خواص آنتی‌اکسیدانی و ضدسرطانی عصاره میوه درخت ارس (Juniperus polycarpos) بر روی سلول سرطانی پستان MCF7
سهیلا معینی احسان کریمی احسان اسکوئیان

10.22034/ascij.2023.1954620.1373

گیاه ارس (Juniperus polycarpos) دارای ترکیبات طبیعی زیست فعالی است که برای تولید داروهای ضد التهابی و ضد سرطانی استفاده می شود. هدف این مطالعه بررسی خواص آنتی اکسیدانی و ضدسرطانی عصاره میوه درخت ارس بر روی سلول سرطانی پستان MCF7 می باشد. برای این منظور،جهت عصاره گیری، م أکثر

گیاه ارس (Juniperus polycarpos) دارای ترکیبات طبیعی زیست فعالی است که برای تولید داروهای ضد التهابی و ضد سرطانی استفاده می شود. هدف این مطالعه بررسی خواص آنتی اکسیدانی و ضدسرطانی عصاره میوه درخت ارس بر روی سلول سرطانی پستان MCF7 می باشد. برای این منظور،جهت عصاره گیری، میوه درخت ارس به مدت 7 روز خشک و سپس به آن ترکیب متانول و HCL اضافه و با همزن مغناطیسی هم زده و پس از قرارگیری در دستگاه تقطیر از طریق کاغذ واتمن فیلتر شد. جهت ارزیابی فعالیت آنتی اکسیدانی عصاره میوه درخت ارس از روش DPPH استفاده و میزان جذب رادیکال های آزاد در طول موج 517 نانومتر خوانده شد. جهت تعیین مقدار IC50از ویتامین C به عنوان یک آنتی اکسیدان استاندارد استفاده شد. سلول سرطانی پستان MCF7 کشت و اثر سایتوتوکسیسیتی عصاره بعد از 48 ساعت به روش MTT assay محاسبه شد. برای تعیین سمیت عصاره از مدل موشی Balb/c استفاده و بعد از تیمار با دوزهای (25، 50 و 100 میلی گرم/کیلوگرم) خون گیری جهت بررسی تغییر تعداد سلول های خونی و جداسازی بافت های کبد، کلیه، روده، طحال جهت تغییرات مورفولوژیکی و بافت‌شناسی انجام شد. درصد مهارکنندگی آنتی اکسیدان عصاره میوه درخت ارس در غلظت300 میکروگرم در میلی لیتر، به ترتیب با دو روش DPPH وFRAP 25/2 ± 47/59 و 09/2±19/63 درصد بوده و این مقادیر از میزان استاندارد‌ بکاررفته یعنی ویتامین C کمتر بود. 9/66 میکروگرم بر میلی لیتر از عصاره میوه توانست 50 درصد از رشد سلول های سرطانی پستان را در طی مدت زمان 48 ساعت مهار کند. آنالیز سلول های خونی و بافتی تغییرات معنی داری را در تعداد سلول های خونی و تغییرات مورفولوژیکی بافتی نشان نداد. یافته ها، اثر سایتوتوکسیسیتی عصاره برروی سلول های سرطان پستان را نشان داد. از طرفی عصاره باعث مسمومیت در مدل موشی نشده و برروی بافت های حیوان و سلول های خونی تاثیر معنی داری نداشته است. تفاصيل المقالة

حرية الوصول المقاله

19 - اثر نانوذره اکسید روی (ZnO) عامل‌دار شده با گلوتامیک اسید و کنژوگه با تیوسمی کاربازید (TSC) بر روی بیان ژن‌های Bax، bcl-2 و caspase-3 در رده سلولی آدنوکارسینومای معده
صدف بیگی علی صالح زاده هادی حبیب اللهی سید عطااله سادات شاندیز فریبا صفا

10.22034/ascij.2022.1936578.1279

کنژوگه کردن نانوذرات فلزی با تیوسمی کاربازید یا مشتقات آن می توند منجر به بهبود پایداری و قابلیت ضدسرطانی آنان از طریق القاء آپوپتوزیس در سلول‌های سرطانی شود. بنابراین، هدف از این مطالعه سنتز نانوذرات اکسید روی عامل دار شده با گلوتامیک اسید کنژوگه شده با تیو سمی کاربازی أکثر

کنژوگه کردن نانوذرات فلزی با تیوسمی کاربازید یا مشتقات آن می توند منجر به بهبود پایداری و قابلیت ضدسرطانی آنان از طریق القاء آپوپتوزیس در سلول‌های سرطانی شود. بنابراین، هدف از این مطالعه سنتز نانوذرات اکسید روی عامل دار شده با گلوتامیک اسید کنژوگه شده با تیو سمی کاربازید (Zn@Glu/TSC) و سپس ارزیابی قابلیت ضد سرطانی آنان از طریق سنجش سمیت سلولی و بیان ژن‌های دخیل در تنظیم آپوپتوزیس در سلول‌های آدنوکارسینومای معده (AGS) است. ویژگی‌های فیزیکی-شیمیایی نانوذرات سنتز شده از طریق آنالیزهای FT-IR، میکروسکوپ الکترونی نگاره و گذاره و اندازه‌گیری پتانسیل زتا تعیین گردید. میزان سمیت سلولی و دوز مهاری میانه نانوذرات بر سلول‌های AGS از طریق آزمایش MTT تعیین گردید. سپس میزان بیان ژن‌های caspase-3، bax و bcl-2 در سلول‌های مواجهه یافته با نانوذرات از طریق آزمایش Real time PCR مورد ارزیابی قرا گرفت. نتایج نشان داد که نانوذرات ساخته‌شده کروی بوده و دارای اندازه 10 تا 90 نانومتر بودند. ماهیت ذرات توسط طیف‌سنجی FT-IR تائید شد و مقدار پتانسیل زتا نیز mV 7/11- به دست آمد. نانوذرات ساخته‌شده در غلظت‌های µg/mL 62/15 و بالاتر به‌طور چشمگیری باعث کاهش زنده‌مانی سلول‌های AGS شدند و مقدار دوز مهاری میانه µg/mL 90 به دست آمد. همچنین، در سلول‌های مواجهه یافته با نانوذرات بیان ژن‌های caspase-3 و bax به میزان 67/1 و 80/1 برابر افزایش داشت درحالی‌که میزان بیان ژن bcl-2 به میزان 70/0 برابر در مقایسه با سلول‌های کنترل کاهش معنی‌دار داشت. تفاصيل المقالة

فهرس المقالات anticancer

سند

الروابط

المراكز ذات الصلة

دعامة

الصفحات الرسمية