reaction of thiohydantoins and ethylbromopyruvate for Synthesis of imidazo[2,1-b]thiazole 3-carboxylate
الموضوعات : International Journal of Heterocyclic Chemistry
Nasimeh Zarei
1
,
Mohammad Mehdi Ghanbari
2
,
Marzieh Jamali
3
,
Mahboobeh Kiamarsi
4
,
Pegah Mohagheghzadeh
5
1 - Young Researchers and Elite Club, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran,
2 - Young Researchers and Elite Club, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran
3 - Young Researchers and Elite Club, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran
4 - Young Researchers and Elite Club, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran
5 - Young Researchers and Elite Club, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran
الکلمات المفتاحية: Thiohydantoin, Imidazo[2, 1-b]thiazole, Ethylbromopyruvate, anticancer, Thioxoimidazolidin,
ملخص المقالة :
Imidazo[2,1-b]thiazoles are obtaind in excellent yields from the addition reaction between thiohydantoin and ethylbromopyruvate. These imidazo[2,1-b]thiazoles in the presence of p-TSA in boiling toluene refluxed for 2.5 hours led to imidazo[2,1-b]thiazole-3-carboxylates in elimination reactions
[1] A. Andreani, M. Rambaldi, F. Andreani, R. Bossa and I. Galatulas, Eur. J. Med. Chem 1988, 23, 385.
[2] J. Chern, Y. Liaw, C. Chen, J. Rong and C. Huang, Heterocycles 1993, 36, 1091.
[3] A. Andreani, M. Rambaldi, A. Leoni, A. Locatelli and R. Bossa, J. Med. Chem 1996, 39, 2852.
[4] N. Terzioglu and A. Gursoy, Eur. J. Med. Chem, 2003, 38, 781.
[5] A. Andreani, M. Granaiola, A. Leoni, A. Locatelli, R. Morigi, M. Rambaldi, G. Giorgi, L. Salvini and V. Garaliene, Anti-Cancer Drug Des, 2001, 16, 167.
[6] G. Kolavi, V. Hegde and I. A. Khazi, Tetrahedron Letters, 2006, 47, 2811.
[7] R. B. Blackshire and C. J. Sharpe, J. Chem. Soc. C, 1971, 3602.
[8] M. M. Ghanbari, Monatsh Chem, 2011, 142, 749.
[9] I. Yavari, M. M. Ghanbari, J. Azizia and F. Sheikholeslami, J. Chem. Res, 2011, 5, 87.
[10] M. M. Ghanbari, G. H. Mahdavinia, J. Safari, H. Naeimi and M. Zare, Synth. Commun, 2011, 16, 2414.
[11] J. Safari, H. Naeimi, M. M. Ghanbari and O. Sabzi-Fini, Russ. J. Org. Chem, 2009, 45, 477.
