reaction of thiohydantoins and ethylbromopyruvate for Synthesis of imidazo[2,1-b]thiazole 3-carboxylate
محورهای موضوعی : Journal of Chemical Reactivity and SynthesisNasimeh Zarei 1 , Mohammad Mehdi Ghanbari 2 , Marzieh Jamali 3 , Mahboobeh Kiamarsi 4 , Pegah Mohagheghzadeh 5
1 - Young Researchers and Elite Club, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran,
2 - Young Researchers and Elite Club, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran
3 - Young Researchers and Elite Club, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran
4 - Young Researchers and Elite Club, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran
5 - Young Researchers and Elite Club, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran
کلید واژه: Thiohydantoin, Imidazo[2, 1-b]thiazole, Ethylbromopyruvate, anticancer, Thioxoimidazolidin,
چکیده مقاله :
Imidazo[2,1-b]thiazoles are obtaind in excellent yields from the addition reaction between thiohydantoin and ethylbromopyruvate. These imidazo[2,1-b]thiazoles in the presence of p-TSA in boiling toluene refluxed for 2.5 hours led to imidazo[2,1-b]thiazole-3-carboxylates in elimination reactions
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