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حرية الوصول المقاله
1 - One –Pot Synthesis of Polyhydroquinoline Derivatives via Hantzsch Condensation Reaction Using Nanosized Magnesium Oxide as Heterogeneous Catalyst
Hakimeh Mirzaee Ahmad Izadyar Abolghsem Davoodnia Hoseyn EshghiAn efficient, recyclable and environmental-friendly synthetic route to polyhdroquinoline derivatives have been developed via multi-component one-pot Hantzsch reaction of various aromatic aldehyde, 2 equivalents of 5,5-dimethyl-1,3-cyclohexanedione (dimedone), ethyl acet أکثرAn efficient, recyclable and environmental-friendly synthetic route to polyhdroquinoline derivatives have been developed via multi-component one-pot Hantzsch reaction of various aromatic aldehyde, 2 equivalents of 5,5-dimethyl-1,3-cyclohexanedione (dimedone), ethyl acetoacetate and ammonium acetate using nano magnesium oxide as a catalyst in ethanol under reflux condition. Reaction with 4-chlorobenzaldehyde was selected as the model reaction and different conditions for temperature, amount of catalyst and kind of solvent have been studied on it. It was found that 0.03 g catalyst in reflux condition and ethanol as solvent is the optimum condition which resulted in 94% yield. The present approach offers several advantages such as short reaction times, easy isolation and purification of product, and safe, non-toxic, recyclable and economic use of catalyst. تفاصيل المقالة -
حرية الوصول المقاله
2 - اکسید آهن سولوفونه شده آبگریز: یک نانوکاتالیست ناهمگن قابل بازیافت مغناطیسی جدید برای سنتز چهار جزئی تک ظرفی هگزا هیدروکینولین ها
سارا سبحانی تکتم یاری رویا جهانشاهییک نانوکاتالیست مغناطیسی سولفونه ناهمگن جدید که توسط گروههای اکتیلی آبگریز شده و باعلامت اختصاری NBS-γ-Fe2O3-Hydrophobic نشان داده شده است، با موفقیت سنتز و با روش های مختلف مانند FT-IR، SEM، TEM، TGA و آنالیز عنصری شناسایی شد. این کاتالیزور برای سنتز کارآمد هگزا أکثریک نانوکاتالیست مغناطیسی سولفونه ناهمگن جدید که توسط گروههای اکتیلی آبگریز شده و باعلامت اختصاری NBS-γ-Fe2O3-Hydrophobic نشان داده شده است، با موفقیت سنتز و با روش های مختلف مانند FT-IR، SEM، TEM، TGA و آنالیز عنصری شناسایی شد. این کاتالیزور برای سنتز کارآمد هگزا هیدروکینولین ها(HHQs) از طریق واکنش های چهار جزئی هانش تک ظرفی تحت شرایط بدون حلال به خوبی عمل کرد. افزایش فعالیت کاتالیزوری Hydrophobic-NBS-γ-Fe2O3 را می توان به اثرات هم افزایی گروه های اسید سولفونیک و گروههای آبگریز تثبیت شده بر روی سطح کاتالیزور نسبت داد. وجود گروههای آبگریز به خوبی مشکل مسمومیت مکان های اسیدی با آب را در سنتزHHQ ها که درآن آب تولید می شود، حذف می کند. همچنین انتقال مواد اولیه را که آبگریز هستند، به سایت های فعال اسیدی کاتالیزور تسهیل می کند. استفاده از شرایط بدون حلال، راندمان خوب تا عالی محصولات، استفاده از کاتالیزور قابل استفاده مجدد، زمان واکنش کوتاه و روش کار ساده، این روش را از نظر محیط زیستی و اقتصادی برای سنتزHHQ ها مطلوب می کند. این مطالعه اولین نمونه از کاربرد یک نانوکاتالیست مغناطیسی سولفونه آبگریز برای سنتز چهار جزئی یک مرحله ایHHQ ها می باشد. تفاصيل المقالة -
حرية الوصول المقاله
3 - A Novel, Heterogeneous Catalyst for the One-Pot Synthesis of 1,8-Dioxodecahydroacridine Derivatives Under Solvent-Free Conditions
Tayebeh Sanaeishoar Mitra SaremiAn efficient and environmental-friendly synthetic route to 1,8-dioxodecahydroacridines derivatives have been developed via multi-component one-pot Hantzsch reaction of various aldehydes and ammonium acetate with 2 equivalents dimedone in the presence of Phosphorus pento أکثرAn efficient and environmental-friendly synthetic route to 1,8-dioxodecahydroacridines derivatives have been developed via multi-component one-pot Hantzsch reaction of various aldehydes and ammonium acetate with 2 equivalents dimedone in the presence of Phosphorus pentoxide supported on aluminaas catalyst under solvent-free conditions. The present approach offersseveral advantages such as short reaction times, easy isolation and purification of product, and safe, non-toxic, recyclable and economic use of catalyst. تفاصيل المقالة -
حرية الوصول المقاله
4 - A Novel protocol for synthesis of Hantzsch 1, 4- dihydropyridines using PEG-400 as a reaction medium and under catalyst-free condition
Ali Ezabadi Fatemeh TosanAn efficient and expeditious catalyst-free procedure was developed for the one- pot synthesis of 1, 4-dihydropyridine derivatives via the three-component reaction of various aldehydes, ethyl acetoacetate, and ammonium acetate in PEG-400. The reaction was carried out at أکثرAn efficient and expeditious catalyst-free procedure was developed for the one- pot synthesis of 1, 4-dihydropyridine derivatives via the three-component reaction of various aldehydes, ethyl acetoacetate, and ammonium acetate in PEG-400. The reaction was carried out at 110°С and the products were obtained in good to high yields. تفاصيل المقالة -
حرية الوصول المقاله
5 - Novel procedure for preparation of Hantzsch 1, 4- dihydropyridines using PEG-400 as a reaction medium and under catalyst-free condition
Ali Ezabadi Fatemeh TosanAn efficient and expeditious catalyst-free procedure was developed for the one- pot synthesis of 1, 4-dihydropyridine derivatives via the three-component reaction of various aldehydes, ethyl acetoacetate, and ammonium acetate in PEG-400. The reaction was carried out at أکثرAn efficient and expeditious catalyst-free procedure was developed for the one- pot synthesis of 1, 4-dihydropyridine derivatives via the three-component reaction of various aldehydes, ethyl acetoacetate, and ammonium acetate in PEG-400. The reaction was carried out at 110°С and the products were obtained in good to high yields. تفاصيل المقالة -
حرية الوصول المقاله
6 - Heterogeneous Catalyst for the One-Pot Synthesis of 1,8-Dioxodecahydroacridine
Haleh Sanaeishoar Mitra SeramiAn efficient and environmental-friendly synthetic route to 1,8-dioxodecahydroacridines derivatives have been developed via multi-component one-pot Hantzsch reaction of various aldehydes and ammonium acetate with 2 equivalents dimedone in the presence of Phosphorus pento أکثرAn efficient and environmental-friendly synthetic route to 1,8-dioxodecahydroacridines derivatives have been developed via multi-component one-pot Hantzsch reaction of various aldehydes and ammonium acetate with 2 equivalents dimedone in the presence of Phosphorus pentoxide supported on aluminaas catalyst under solvent-free conditions. The present approach offersseveral advantages such as short reaction times, easy isolation and purification of product, and safe, non-toxic, recyclable and economic use of catalyst. تفاصيل المقالة -
حرية الوصول المقاله
7 - Phospho sulfonic acid: an efficient solid acid catalyst for the facile preparation of 1,4-dihydropyridines
Sobhan Rezayati Parisa JavanmardiA simple and mild one-pot three-component reaction for the preparation 1,4-dihydropyridines has been developed from various aldehyde substrates, 1,3-dicarbonyl compounds (dimedone) and ammonium acetate (Hantzsch method) in the presence of a catalytic amount of phospho s أکثرA simple and mild one-pot three-component reaction for the preparation 1,4-dihydropyridines has been developed from various aldehyde substrates, 1,3-dicarbonyl compounds (dimedone) and ammonium acetate (Hantzsch method) in the presence of a catalytic amount of phospho sulfonic acid (PSA) as an efficient and heterogeneous solid acid in EtOH at room temperature. Preparation of PSA is straightforward and handling of the reagent is also easy. The attractive features of this protocol are: (i) The elimination of corrosive liquid acids; (ii) the use of an inexpensive and relatively non-toxic catalyst, and (iii) reusability of the catalyst. تفاصيل المقالة -
حرية الوصول المقاله
8 - Fe3O4/SiO2/(CH2)3N+Me3Br3– core–shell nanoparticles: An efficient catalyst for the synthesis of functionalized 5-oxo-hexahydroquinolines
Azita Farrokhi Issa Yavari Keivan GhodratiThe four-component Hantzsch condensation reaction of dimedone, ethyl acetoacetate, ammonium acetate, and various aromatic and aliphatic aldehydes in the presence of catalytic amount of a magnetic nanoparticle-supported tribromide, as a green catalyst, under solvent‐free أکثرThe four-component Hantzsch condensation reaction of dimedone, ethyl acetoacetate, ammonium acetate, and various aromatic and aliphatic aldehydes in the presence of catalytic amount of a magnetic nanoparticle-supported tribromide, as a green catalyst, under solvent‐free conditions at 80 °C affords functionalized 5-oxo-hexahydroquinolines in good to excellent yields. The magnetic Fe3O4-SiO2-(CH2)3N+Me3Br3–, was characterized by infrared spectroscopy (FT-IR), X-ray diffraction (XRD) spectroscopy, transmission electron microscope (TEM) and vibrating sample magnetometer (VSM). The method offers several advantages including high yields, short reaction time, simple work-up procedure and catalyst reusability for several runs. The catalyst could be readily separated by using a magnetic force and reused six times without any significant loss of catalytic activity. تفاصيل المقالة -
حرية الوصول المقاله
9 - Novel acidic ChCl/TFA DES as reaction medium and catalyst for Biginelli and Hantzsch reactions
Adeleh Moshtaghi Zonouz Abdolreza Abri Nasrin babajani Hemayat ShekaariNovel deep eutectic solvent (DES) using Choline Chloride (ChCl) as the hydrogen bond acceptor and triflouroacetic acid (TFA) as hydrogen bond donor (1.0:1.5 molar ratio) was prepared at room temperature and characterized by FT- IR and 1H NMR spectroscopy. Also, this nov أکثرNovel deep eutectic solvent (DES) using Choline Chloride (ChCl) as the hydrogen bond acceptor and triflouroacetic acid (TFA) as hydrogen bond donor (1.0:1.5 molar ratio) was prepared at room temperature and characterized by FT- IR and 1H NMR spectroscopy. Also, this novel acidic RTDES (room temperature deep eutectic solvent) was successfully used both as a reaction medium and catalyst in Biginelli, Biginelli-like, and Hantzsch reactions. The procedures have the advantages of high yields, short reaction times and easy work-up as well as relatively mild conditions and they do not require additional catalysts and organic solvents. The DES could be easily recycled without considerable loss of activity even after more than three cycles. تفاصيل المقالة -
حرية الوصول المقاله
10 - Nanocrystalline TiO2 as an efficient and reusable catalyst for the one-pot synthesis of polyhydroquinolien derivatives via Hantzsch reaction
Farhad Shirini Seyyed Vahid Atghia Meysam Alipour KhoshdelAn efficient synthesis of polyhydroquinoline derivatives was reported via four-component coupling reactions of aldehydes, 1,3-dicarbonyl ketones (dimedone or 1,3-cyclohexanedione), ethyl acetoacetate or methyl acetoacetate and ammonium acetate in the presence of a catal أکثرAn efficient synthesis of polyhydroquinoline derivatives was reported via four-component coupling reactions of aldehydes, 1,3-dicarbonyl ketones (dimedone or 1,3-cyclohexanedione), ethyl acetoacetate or methyl acetoacetate and ammonium acetate in the presence of a catalytic amount of nanocrystalline TiO2 under solvent free conditions. The reported method is mild, rapid and has the advantages such as heterogeneous catalysis, simple work-up procedure, recyclability of the catalyst and purification of products without chromatographic methods. تفاصيل المقالة -
حرية الوصول المقاله
11 - Synthesis and Study of the Effect New Pyrazoles and Oxadiazole Linked to the 1,4-Dihydropyridine Ring on Breast Cancer
Adiba Saaduldeen Ali Tahseen Saddam Fandi Al-MathkuriThe Hantzsch reaction created a new series comprising 1,4-dihydropyridine pyrazoles and oxa diazoles (DHP) by initially synthesizing DHP esters, then its carbohydrates, and subsequent treatment with hydrazine. Pyrazole derivatives (Am1 and Am2) were obtained via the rea أکثرThe Hantzsch reaction created a new series comprising 1,4-dihydropyridine pyrazoles and oxa diazoles (DHP) by initially synthesizing DHP esters, then its carbohydrates, and subsequent treatment with hydrazine. Pyrazole derivatives (Am1 and Am2) were obtained via the reaction of hydrazines with acetylacetone or ethyl acetoacetate, whereas the oxadiazole derivative (Am3) was prepared via reaction with carbon disulfide in an alkaline medium. The prepared compounds were identified using spectroscopic techniques (FTIR, 1H and 13C NMR, and mass spectrometry). The anti-breast cancer activity of new compounds was evaluated. This cytotoxicity activity afforded that compound (AS) was the strongest in this group together with an IC50 = 100.24µg mL-1, whereas compound (AT) demonstrated the lowest potency, with an IC50 value of 300 µg mL-1. The Hantzsch reaction was used in the synthesis of a new 1,4-dihydropyridine that has pyrazole and oxadiazole moieties. The activity of in vitro cytotoxicity (MTT cell viability assay) was determined. In vitro MCF7 cells were used in the evaluation of the cytotoxicity activity (MTT cell viability assay) of new compounds. This cytotoxicity activity meant that compound (AS) was the strongest in this group, with an IC50 of 100.24 µg mL-1, while compound (AT) had the least potency, with an IC50 value of 300 µg mL-1. Based on our findings, we can infer that 1,4-dihydropyridine derivatives (DHPs) are noteworthy heterocyclic compounds with pharmacological potential. This cytotoxicity activity meant that compound (AS) was the strongest in this group, with an IC50 of 100.24 µg mL-1, while compound (AT) had the least potency, with an IC50 value of 300 µg mL-1. تفاصيل المقالة
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