ارزيابي اثرات همزمان فعالیت بدنی و گیاهان دارویی بر کنترل دیابت، چربی خون و استرس اکسیداتیو
محورهای موضوعی : دسترسی آزادشهلا هاشمي 1 * , حسين علي هاشمي شهركي 2
1 - دانشگاه سيستان و بلوچستان
2 - گروه تربیت بدنی و علوم ورزشی، دانشکده تربیت بدنی و علوم ورزشی، دانشگاه تهران، تهران، ایران
کلید واژه: گیاهان دارویی, تمرین ورزشی, دیابت,
چکیده مقاله :
ارزيابي اثرات همزمان فعالیت بدنی و گیاهان دارویی بر کنترل دیابت، چربی خون و استرس اکسیداتیو
چکیده
دیابت، اختلال چربی خون و استرس اکسیداتیو از مهم‌ترین عوامل تهدیدکننده سلامت انسان در قرن حاضر محسوب می‌شوند. علاوه بر درمان‌های دارویی، بهره‌گیری ازروش‌های مکمل مانند انجام ورزش به طور منظم و بهره‌مندی از گیاهان دارویی با خواص ضدالتهابی و آنتی‌اکسیدانی، به عنوان روشی مؤثر و با عوارض جانبی کم مورد توجه قرار گیرد. هدف این مقاله ارزيابي اثرات همزمان فعالیت بدنی و گیاهان دارویی در بهبود شاخص‌های متابولیک و اکسیداتیو در بیماران مبتلا به دیابت نوع ۲ و دیس‌لیپیدمی تدوین شده است. نتایج حاکی از آن است که کاهش فاکتورهای التهابی، بهبود حساسیت به انسولین، کاهش سطح لیپیدهای خون و محصولات اکسیداتیو می‌تواند از ترکیب تمرینات ورزشی و مصرف برخی گیاهان دارویی حاصل شود این یافته‌ها بر اهمیت انجام پژوهش‌های بالینی بیشتر برای مشخص کردن مقدار مصرف، گونه گیاه دارویی و میزان شدت تمرین تأکید دارند.
واژگان کلیدی: گیاهان دارویی، تمرین ورزشی، دیابت
Abstract
Diabetes, dyslipidemia (lipid metabolism disorder), and oxidative stress are considered among the most significant threats to human health in the present century. In addition to pharmacological treatments, the utilization of complementary methods such as regular exercise and the use of medicinal plants with anti-inflammatory and antioxidant properties should be considered as an effective approach with fewer side effects. The aim of this article is to evaluate the simultaneous effects of physical activity and medicinal plants on improving metabolic and oxidative markers in patients with type 2 diabetes and dyslipidemia. The results indicate that a reduction in inflammatory factors, improved insulin sensitivity, decreased levels of blood lipids and oxidative products can be achieved through the combination of exercise training and the consumption of certain medicinal plants. These findings emphasize the importance of conducting further clinical research to determine the dosage, species of medicinal plant, and intensity of exercise..
Keywords: Medicinal Plants, Exercise Training, Diabetes
1. Habib, S.H. and Saha, S., 'Burden of Non-Communicable Disease: Global Overview', Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 2010, 4, (1), pp. 41-47.
2. Birben, E., Sahiner, U.M., Sackesen, C., Erzurum, S., and Kalayci, O., 'Oxidative Stress and Antioxidant Defense', World Allergy Organization Journal, 2012, 5, (1), pp. 9-19.
3. Chen, C.K., Muhamad, A.S., and Ooi, F.K., 'Herbs in Exercise and Sports', Journal of Physiological Anthropology, 2012, 31, (1), p. 4.
4. Sellami, M., Olfa, S., Andrzej, P., Goran, K., Lawrence, D.H., Mirjana, M., and and Padulo, J., 'Herbal Medicine for Sports: A Review', Journal of the International Society of Sports Nutrition, 2018, 15, (1), p. 14.
5. Ribeiro, D., Freitas, M., Lima, J.L.F.C., and Fernandes, E., 'Proinflammatory Pathways: The Modulation by Flavonoids', Medicinal Research Reviews, 2015, 35, (5), pp. 877-936.
6. Shahraki, S.H., Ahmadi, T., Jamali, B., and Rahimi, M., 'The Biochemical and Growth-Associated Traits of Basil (Ocimum Basilicum L.) Affected by Silver Nanoparticles and Silver', BMC Plant Biology, 2024, 24, (1), p. 92.
7. Babaei, M., Shabani, L., and Hashemi-Shahraki, S., 'Improving the Effects of Salt Stress by Β-Carotene and Gallic Acid Using Increasing Antioxidant Activity and Regulating Ion Uptake in Lepidium Sativum L', Botanical Studies, 2022, 63, (1), p. 22.
8. Shahraki, S.H., Javar, F.M., Jamali, B., and sargazi, F., 'Beneficial Role of Coronatine on the Morphological and Physiological Responses of Cress Plants (Lepidium Sativum) Exposed to Silver Nanoparticle', Botanical Studies, 2024, 65, (1), p. 17.
9. Gauttam, V.K., Munjal, K., Chopra, H., Ahmad, A., Rana, M.K., and Kamal, M.A., 'A Mechanistic Review on Therapeutic Potential of Medicinal Plants and Their Pharmacologically Active Molecules for Targeting Metabolic Syndrome', Current Pharmaceutical Design, 2024, 30, (1), pp. 10-30.
10. Yatoo, M.I., Gopalakrishnan, A., Saxena, A., Parray, O.R., Tufani, N.A., Chakraborty, S., Tiwari, R., Dhama, K., and Iqbal, H.M.N., 'Anti-Inflammatory Drugs and Herbs with Special Emphasis on Herbal Medicines for Countering Inflammatory Diseases and Disorders - a Review', Recent Patents on Inflammation & Allergy Drug Discovery, 2018, 12, (1), pp. 39-58.
11. Rubió, L., Maria-José, M., and and Romero, M.-P., 'Recent Advances in Biologically Active Compounds in Herbs and Spices: A Review of the Most Effective Antioxidant and Anti-Inflammatory Active Principles', Critical reviews in food science and nutrition, 2013, 53, (9), pp. 943-953.
12. Singletary, K.W., 'Fenugreek: Overview of Potential Health Benefits', Nutrition Today, 2017, 52, (2), pp. 93-111.
13. Wilson, P.B., 'Ginger (Zingiber Officinale) as an Analgesic and Ergogenic Aid in Sport: A Systemic Review', The Journal of Strength & Conditioning Research, 2015, 29, (10), pp. 2980-2995.
14. Wilson, P.B., 'A Randomized Double-Blind Trial of Ginger Root for Reducing Muscle Soreness and Improving Physical Performance Recovery among Experienced Recreational Distance Runners', Journal of Dietary Supplements, 2020, 17, (2), pp. 121-132.
15. Anderson, R.A., Zhan, Z., Luo, R., Guo, X., Guo, Q., Zhou, J., Kong, J., Davis, P.A., and Stoecker, B.J., 'Cinnamon Extract Lowers Glucose, Insulin and Cholesterol in People with Elevated Serum Glucose', Journal of Traditional and Complementary Medicine, 2016, 6, (4), pp. 332-336.
16. Tipoe, G.L., Leung, T.-M., Hung, M.-W., and Fung, M.-L., 'Green Tea Polyphenols as an Anti-Oxidant and Anti-Inflammatory Agent for Cardiovascular Protection', Cardiovascular & Haematological Disorders - Drug Targets, 2007, 7, (2), pp. 135-144.
17. Marin, D.P., Bolin, A.P., Campoio, T.R., Guerra, B.A., and Otton, R., 'Oxidative Stress and Antioxidant Status Response of Handball Athletes: Implications for Sport Training Monitoring', International Immunopharmacology, 2013, 17, (2), pp. 462-470.
18. Sielski, Ł., Sutkowy, P., Pawlak-Osińska, K., Woźniak, A., Skopowska, A., Woźniak, B., and Czuczejko, J., 'The Impact of Modern Therapeutic Methods on the Oxidant-Antioxidant Equilibrium and Activities of Selected Lysosomal Enzymes and Serine Protease Inhibitor in Amateur Athletes', Oxidative medicine and cellular longevity, 2020, 2020, (1), p. 9792836.
19. Tryfidou, D.V., McClean, C., Nikolaidis, M.G., and Davison, G.W., 'DNA Damage Following Acute Aerobic Exercise: A Systematic Review and Meta-Analysis', Sports Medicine, 2020, 50, (1), pp. 103-127.
20. Sellami, M., Almuraikhy, S., Naja, K., Anwardeen, N., Al-Amri, H.S., Prince, M.S., Aden, A.A., Doemling, A., and Elrayess, M.A., 'Eight Weeks of Aerobic Exercise, but Not Four, Improves Insulin Sensitivity and Cardiovascular Performance in Young Women', Scientific Reports, 2025, 15, (1), p. 1991.
21. Ashcroft, S.P., Stocks, B., Egan, B., and Zierath, J.R., 'Exercise Induces Tissue-Specific Adaptations to Enhance Cardiometabolic Health', Cell Metabolism, 2024, 36, (2), pp. 278-300.
22. Coşkun, R.B. and Dağlıoğlu, Ö., 'The Effects of Pilates Exercises on Body Composition and Flexibility in Sedentary Women', European Journal of Physical Education and Sport Science, 2023, 9, (3).
23. Sharafi, S., Hassanpour, G., and Noura, M., 'The Effect of Pilates Training Along with Saffron Consumption on Body Composition of Female', Researches in Sport Sciences and Medical Plants, 2020, 1, (1), pp. 58-66.
24. Fateh, H.L. and Amin, S.M., 'Effects of Cinnamon Supplementation on Lipid Profile: A Systematic Review and Meta-Analysis of Randomized Controlled Trials', Clin Nutr Res, 2024, 13, (1), pp. 74-87.
25. Yu, Z., Wang, W., Yang, K., Gou, J., Jiang, Y., and Yu, Z., 'Sports and Chinese Herbal Medicine', Pharmacological Research - Modern Chinese Medicine, 2023, 9, p. 100290.