بررسی تأثیر هشت هفته تمرینات سبک مقاومتی بر بیان 178CD زنان غیر ورزشکار

محورهای موضوعی : فعالیت بدنی و تندرستی

زینت ابراهیمی ¹ (تربیت بدنی و علوم ورزشی، دانشکده علوم انسانی، دانشگاه آزاد اسلامی واحد سنندج، سنندج، ایران)
پریوش پیرکی ² (تربیت بدنی و علوم ورزشی، دانشکده علوم انسانی، دانشگاه آزاد اسلامی واحد دره شهر، ایلام، ایران)

تاریخ دریافت : 1400/11/06 تاریخ پذیرش : 1401/03/11 تاریخ انتشار : 1401/04/01

کلید واژه:

چکیده مقاله :

آپوپتوز یا مرگ برنامه‌ریزی شده سلولی، نقش اصلی را در حذف سلول‌های از کار افتاده دارد. این پدیده، یک رخداد طبیعی و فیزیولوژیک است که فقدان آن می‌تواند منجر به سرطانی شدن سلول‌ها شود. لذا پژوهش حاضر با هدف بررسی تأثیر هشت هفته تمرینات متعادل بدنسازی بر میزان بیان 178CD لنفوسیتی در زنان غیر ورزشکار پرداخت. در راستای این هدف 30 دانشجوی زن غیر ورزشکار داوطلبانه در تحقیق شرکت کردند و به صورت تصادفی انتخاب و به دو گروه مساوی تجربی و کنترل تقسیم شدند. برخلاف گروه کنترل، گروه تجربی هشت هفته تمرینات بدنسازی را اجرا کردند. نمونه‌های ‌خون قبل و بعد از هشت هفته، و با فاصله 24 ساعت نسبت به اخرین جلسه تمرینات بعد جمع‌آوری شدند. آزمون تحلیل واریانس دو عاملی و اندازه‌گیری‌های مکرر برای تجزیه و تحلیل داده‌ها استفاده شدند. نتایج نشان دادند بیان 178CD لنفوسیتی در دو گروه متفاوت بودند. مقادیر گیرنده 178CD در گروه تجربی بعد از هشت هفته نسبت به مقادیر اولیه تفاوت معنی‌دار داشت (001/0=P)، اما کاهش معنی‌داری در اندازه‌گیری 24 ساعت بعد از فعالیت، در گروه تجربی دیده نشد (040/0=P). بر اساس نتایج به دست آمده از گروه تجربی می‌توان نتیجه گرفت که تمرینات سبک مقاومتی تأثیر مثبتی بر بیان گیرنده 178CD داشته است. لذا سیستم ایمنی افرادی که از تمرینات مقاومتی با هدف تندرستی استفاده می‌کنند، می تواند تحت تأثیر این نوع تمرینات تقویت شود. واژه های کلیدی: تمرینات سبک مقاومتی، 178CD ، لنفوسیت‌ها

چکیده انگلیسی:

Apoptosis or programmed cell death plays a major role in removing dead cells. This phenomenon is a natural and physiological event, the lack of which can lead to cancerous cells. Therefore, the present study aimed to investigate the effect of eight weeks of light resistance exercises on the expression level of lymphocyte CD178 in non-athlete women. In line with this goal, 30 non-athlete female students voluntarily participated in the research and were randomly selected and divided into two equal experimental and control groups. Unlike the control group, the experimental group performed eight weeks of light resistance exercises. Blood samples were collected before and after eight weeks, 24 hours later. Two-factor analysis of variance and repeated measurements were used to analyze the data. The results showed that the expression of lymphocyte CD178 was different in two groups. The values CD178 receptors in the experimental group after eight weeks were significantly different from the initial values (P=0.001), but there was no significant decrease in the measurement 24 hours after the activity in the experimental group (P=0.040). Based on the results obtained from the experimental group, it can be concluded that light resistance exercises had a positive effect on the expression of 178CD receptor. Therefore, the immune system of people who use resistance training for the purpose of health can be strengthened under the influence of this type of training.Key words: Resistance Exercises, CD178, Lymphocytes

منابع و مأخذ:

 

Brown, F.F., Bigley, A.B., Sherry, C., Neal, C.M., Witard, O.C., Simpson, R.J., Galloway, S.D.R. (2014). Training status and sex influence on senescent T-lymphocyte redistribution in response to acute maximal exercise. Brain, Behavior, and Immunity, 39, 152–159.

 

Cullen, S.P., Henry, C.M., Kearney, C.J., Logue, S.E., Feoktistova, M., Tynan, G.A. (2013). Fas/CD95-Induced Chemokines Can Serve as "Find-Me" Signals for Apoptotic Cells. Molecular Cell, 19(13), 1034-1048.

 

Dorneles, G.P., Colato, A.S., Galvão, S.L., Ramis, T.R., Ribeiro, J.L. (2015). Acute response of peripheral CCr5 chemoreceptor and NK cells in individuals submitted to a single session of low-intensity strength exercise with blood flow restriction. Clinical Physiology and Functional Imaging, 35.

 

Delfani N, Peeri M, Matin Homaee H. (2021). Effect of Aerobic Exercise and Hydroalcoholic Extract of Tribulus Terrestris on Mitochondrial Oxidative Stress Markers in Heart Tissue of Rats Poisoned With Hydrogen Peroxide. cmja. 11 (1): 30-43. (Persian)

 

Eslami R, Heidary D, Mehdipour A, Heidari S. (2021). The Effects of Acute Exercise and Exercise Training onPlasma Fibrinogen Levels in Healthy Individuals:A Meta-Analysis. Sci J Iran Blood Transfus Organ. 18 (2): 127-141. (Persian)

 

Gordon, P.M., Liu, D., Sartor, M.A., IglayReger, H.B., Pistilli, E.E., Gutmann, L, Nader, G.A., & Hoffman, E.P. (2011). Resistance exercise training influences skeletal muscle immune activation: a microarray analysis. Journal Apply Physiology, 112(3), 443-453.

 

Hovanloo, F., Arefirad, T., Ahmadizad, S. (2013). Effects of sprint interval and continuous endurance training on serum levels of inflammatory biomarkers. Journal of Diabetes & Metabolic Disorders, 12, 22. Doi:  10.1186/2251-6581-12-22.

 

Hoff, P., Belavý, D.L., Huscher, D., Lang, A., Hahne, M., Kuhlmey, A.K, Maschmeyer, P., Armbrecht, G., Fitzner, R., Perschel, F.H., Gaber, T., Burmester, G.R., Straub, R.H., Felsenberg, D., Buttgereit, F. (2014). Effects of 60-day bed rest with and without exercise on cellular and humeral immunological parameters. Cellular & Molecular Immunology, online publication, 1-10. Doi: 10.1038/cmi.2014.106.

 Huang, Ch.Y., Yang, A.L.,  Lin, Y.M., Wu, F.N., Lin, J.A., Chan, Y,  Lin, J.A., Chan, .YS., Tsai, F.J., Tsai, CH., Kuo, CH., Lee, S.D. (2011). Anti-apoptotic and pro-survival effects of exercise training on hypertensive hearts. Journal Apply Physiology, 112(5), 883-891.

 

Hasani S, Habibian M. The effect of regular high-intensity interval exercise on some apoptotic factors in the brain tissue of old female rats. Feyz 2018; 22(2): 128-33. (Persian)

 

Jahani G R, Entezami K, Haydari H, Abkar A, Mollasaeidi Z. (2013). The effect of intensive activity and regular exercise with carbohydrate ingestion on cell-mediated immunity. RJMS. 19 (104) :43-59. (Persian)

 

Jokar M, Sherafati Moghadam M. (2022). Effect of 4 weeks of High-Intensity Interval Training on P53 and Caspase-3 Proteins Content in the Heart Muscle Tissue of Rats with Type 1 Diabetes. JSSU.  29 (11) :4255-4267. (Persian)

 

Koch, M., Hussein, F., Woeste, A., Gründker, C., Frontzek, K., Emons, G., Hawighors, T. (2011). CD36 mediated activation of endothelial cell apoptosis by an N. terminal recombinant fragment of thrombospondin.2 inhibits breast cancer growth and metastasis in vivo. Breast Cancer Research and Treatment, 128(2), 337-346.

 

Krüger, K., Mooren, F.C. (2014). Exercise-induced leukocyte apoptosis. Exercise Immunology Review, 117-134.

 

Kruger, K., Agnischock, S., Lechtermann, A., Tiwari, S., Mishra, M., Pilat, et al. (2011). Intensive resistance exercise induces lymphocyte apoptosis via cortisol and glucocorticoid receptor-dependent pathways. Journal Apply Physiology, 110(5), 1226-1232.

 

Mooren, F.C, Volker, K., Klocke, R., Nikol, S., Waltenberger, J., Kruger, K. (2012). Exercise delays neutrophil apoptosis by a G, CSF, and dependent mechanism. Journal Apply Physiology, 113(7), 1082-1090.

 

Margaritelis, N.V., Kyparos, A., Paschalis, V., Theodorou, A.A., Panayiotou, G., Zafeiridis, A., et al. (2014). Reductive stress after exercise: The issue of redox individuality, Redox Biology, 2, 520–528.

 

Mooren, F.C., Lechtermann, A., Volker, K. (2004). Exercise-induced apoptosis of lymphocytes depends on training status. Medicine & Science in Sports & Exercise, 36(9), 1476-1483.

 

Mooren, F.C., Krüger, K. (2015). Exercise, Autophagy, and Apoptosis. Progress in Molecular Biology and translational Science135,     http://dx.doi.org/10.1016/bs.pmbts.2015.07.023.

 

Mooren FC, Kruger K. (2015). Apoptotic lymphocytes induce progenitor cell mobilization after exercise. Journal Apply physiology, 119 (2), 135–139. http://dx.doi.org/10.1152/japplphysiol.00287.2015.

 

Navalta, J.W., McFarlin, B.K., Lyons, T.S. (2010). Does exercise really induce lymphocyte apoptosis?  Frontiers in Bioscience, (Elite Ed), 2, 478-88.

 

Navalta, J.W, Sedlock, D.A, Park KS. (2007). Effect of exercise intensity on exercise induced lymphocyte apoptosis. International Journal of Sports Medicine, 28(6), 539-542.

 

Navalta, J.W., McFarlin, B.K., Lyons, T.S., Faircloth, J.C., Bacon, N.T., Callahan, Z.J. (2009). Exercise induced lymphocyte apoptosis attributable to cycle ergometer exercise in endurance, trained individuals. Applied Physiology, Nutrition, and Metabolism, 34(4), 603-608.

 

Neves, P.R.D.S., Tenório, T.R.D.S., Lins, T.A., muniz, M.T.C., Curi, T.C.P., Botero, G.P., Prado, W.L.D. (2015). Acute effects of high- and low-intensity exercise bouts on leukocyte counts. Journal of Exercise Science & Fitness, 13(1), 24–28.

Niazi, S., Mirdar, Sh., Bazar, B., Hamidian, Gh., Talebi, V. (2022). evaluation of HIF -1α response and the rate of bronchial and bronchiole apoptosis in lung tissue of male wistar rats in case of decreased exercise load and hypobaric hypoxia conditions belonging to high - intensity interval training. Studies in Medical Sciences, Vol. 32(6), 437-447. (Persian)

Otsuki, T., Shimizu, K., Iemitsu, M., Kono, L. (2012). Chlorella intake attenuates reduced salivary SIgA secretion in kendo training camp participants. Nutrition Journal, 11, 103. Doi:  10.1186/1475-2891-11-103.

 

Simpson, R.J., Florida-James, G.D., Whyte, G.P., Black, J.R., Ross, J.A., Guy, K. (2007). Apoptosis does not contribute to the blood lymphocytopenia observed after intensive and downhill treadmill running in humans. Research in Sports Medicine, 15(3), 157-174.

 

Steinbacher, P., Eckl, P. (2015). Impact of Oxidative Stress on Exercising Skeletal Muscle. Biomolecules, 5(2), 356–377.

 

Simpson, R.J. (2011). Aging, Persistent Viral Infections, and Immunosenescence: Can Exercise "Make Space". Exercise Sport Science Review 39(1), 23-33.

 

Simpson RJ, Kunz H, Agha N, Graff R. (2015). Exercise and the regulation of immune functions. Progress in Molecular Biology and Translational Science. 135: 355-380.

 

Tayebi, S.M., Alinejad, A.H., Shafaee, S.H., Ashori, G.R. (2014). Short-Term Effects of Oral Feeding Jujube Zizi plus Solution before a Single Session of Circuit Resistance Exercise on Apoptosis of Human Neutrophil.  Annals of Applied Sport Science, 2(1), 53-68. (Persian)

 

Tanimura, Y., Kon, M., Shimizu, K., et al. (2009). Effect of 6-day intense Kendo training on lymphocyte counts and its expression of CD95. European Journal of Applied Physiology, 107(2), 227–233.

 

Timmons, B.W., Bar-Or, O. (2006). Lymphocyte expression of CD95 at rest and in response to acute exercise in healthy children and adolescents. Brain, Behavior, and Immunity, 2192007), 442–449.

 

Wang, J.S., Lin, Ch.T. (2010). Systemic hypoxia promotes lymphocyte apoptosis induced by oxidative stress during moderate exercise. European  Journal Apply Physiology, 108(2), 371-382.

 

Zarali M., Etemad Z., Azizbeigi K., Karimi P. (2020). Effect of 8 Weeks of High Intensity Interval Training (HIIT) With and Without Calorie Restriction on Gene Expression of Caspase-3 and Caspase-9 Proteins in Male Rats. J Arak Uni Med Sci. 23 (3): 300-313. (Persian)