بایوسنسور تشدید پلاسمون سطحی مبتنی بر فیبر بلور فوتونی دو شکافه U شکل با حساسیت و تشخیص ضریب شکست بسیار بالا
محورهای موضوعی : مهندسی الکترونیک
سید حسین مؤید
1
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مجتبی صادقی
2
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زهرا عادل پور
3
1 - دانشگاه آزاد - واحد شیراز - گروه مهندسی برق و الکترونیک
2 - گروه مهندسی برق، واحد شیراز، دانشگاه آزاد اسلامی، شیراز، ایران
3 - گروه مهندسی برق- واحد شیراز، دانشگاه آزاد اسلامی، شیراز، ایران
کلید واژه: بایوسنسور, فیبر بلور فوتونی, تشدید پلاسمون سطحی, روش المان محدود,
چکیده مقاله :
در این مقاله یک بایوسنسور تشدید پلاسمون سطحی مبتنی بر فیبر بلور فوتونیِ دوشکافه با حساسیت بسیار بالا معرفی شده است. ساختار پیشنهادی شامل یک حلقه حفره های هوا و یک حلقه حفره از جنس طلا و TiN می‌باشد. به منظور افزایش حساسیت و کارآیی سنسور، دو شکاف U شکل در بالا و پایین ساختار ایجاد شده و لایه نازکی از طلا بر روی آنها قرار گرفته است. مجموعه این مواد و هندسه طراحی شده باعث شده است که شرایط تطبیق فاز به نحو مناسبی برقرار شده و ضریب شکست ماده آنالیت را تشخیص دهد. روش اجزای محدود به منظور شبیه‌سازی عددی، تجزیه و تحلیل مودی و بررسی ویژگی‌های تشدید پلاسمون سطحی بایوسنسور فیبر بلور فوتونی استفاده شده است. نتایج عددی نشان می‌دهد که سنسور دارای حساسیت بسیار بالای 8100 و رزولوشن RIU می‌باشد. همچنین محدوده ضریب شکست قابل تشخیص سنسور بین 35/1 تا 39/1 و ماکزیمم FOM آن برابر با 112 است. با توجه به نتایج بدست آمده، سنسور پیشنهادی یک گزینه بسیار عالی برای کاربردهای تشخیص پزشکی و بایومولکولی می‌باشد.
In this In this paper, a highly sensitive surface plasmon resonance biosensor based on a double-groove photonic crystal fiber has been introduced. The proposed structure consists of an air-hole ring and a gold-TiN-hole ring. To increase the sensitivity and efficiency of the sensor, two U-shaped grooves are created at the top and bottom of the structure and a thin layer of gold is deposited on them. The combination of these materials and the designed geometry has ensured that the phase-matching condition is properly established and the refractive index of the analyte material is detected. The finite element method has been used for numerical simulation, mode analysis, and investigation of the surface plasmon resonance characteristics of the photonic crystal fiber biosensor. Numerical results show that the sensor has a high sensitivity of 8100 and a resolution of RIU. Also, the detectable refractive index range of the sensor is 1.35 to 1.39 and its maximum FOM is 112 . Based on the obtained results, the proposed sensor is an excellent option for medical and biomolecular diagnostic applications.
[1] Vasimalla Y, Salah NH, Santhosh C, Balaji R, Rasul HM, Srither SR, Kumar S. “SMF-based SPR sensors utilizing thallium bromide immobilization for detection of various bacterial cells”, Microchemical Journal, vol. 208, pp. 112312, Jan. 2025. https://doi.org/10.1016/j.microc.2024.112312
[2] Singh NP, Mishra AC, Yadav S, Lohia P, Dwivedi DK. “Numerical analysis of SPR biosensor using zinc telluride, ferric oxide and black phosphorous for malaria detection” Journal of Optics. pp. 1-11, Jan. 2025. https://doi.org/10.1007/s12596-025-02460-w
[3] Xu W, Liu T, Ma Y, Jin M, Wang F, Fan C, Zhangyong Z, Han L. “Highly Sensitive Surface Plasmon Resonance Cancer Cell Biosensor Based on BlueP/TMDCs and MXene Heterostructure”, Plasmonics, pp. 1-11, Jan. 2025. https://doi.org/10.1007/s11468-024-02729-z
[4] Kretschmann, E., & Raether, H. “Radiative decay of non radiative surface plasmons excited by light”, Zeitschrift für Naturforschung A, vol. 23, no. 12, pp. 2135-2136, Dec. 1968. https://doi.org/10.1515/zna-1968-1247
[5] Otto, A., “Excitation of nonradiative surface plasma waves in silver by the method of frustrated total reflection”, Zeitschrift für Physik A Hadrons and nuclei, vol. 216, no. 4, pp. 398-410, Aug. 1968. https://doi.org/10.1007/BF01391532
[6] Jorgenson, R.C. and Yee, S.S., “A fiber-optic chemical sensor based on surface plasmon resonance”, Sensors and Actuators B: Chemical, vol. 12, no. 3, pp. 213-220, Apr. 1993. https://doi.org/10.1016/0925-4005(93)80021-3
[7] Knight, J.C., Birks, T.A., Atkin, D.M. and Russell, P.S.J., “Pure silica single-mode fibre with hexagonal photonic crystal cladding”, In Optical fiber communication conference (p. PD3). Optica Publishing Group, Feb. 1996. rev-01.docx
[8] Zhang, Q., Huang, C., Liao, X., Wang, Y., Tang, J., Hu, J., Shao, W. and Liu, J., “Highly Sensitive PCF Sensor Based on Au-TiO 2 for Cancer Cell Detection”, IEEE Sensors Journal. Feb. 2025. doi: 10.1109/JSEN.2025.3537767.
[9] Mahmud, R.R., Anzum, M.S., Hassan, A.A., Rafsan, A.A., Salimullah, S.M. and Nayan, M.F., “Dual-side polished SPR-PCF ultra-wide refractive index sensor with high amplitude sensitivity”, Journal of Optics, vol. 27, no. 2, pp.025101, Jan. 2025. doi: 10.1088/2040-8986/ada4bd
[10] Zhang, Q., Zhang, Z., Huang, C., Liao, X., Tang, J., Hu, J., Wang, Y. and Shao, W., “Research on D-shape PCF Temperature Sensor with Simple Structure and High Sensitivity”, Optik, vol. 323, pp. 172228, Jan. 2025. https://doi.org/10.1016/j.ijleo.2025.172228
[11] Fan, Z., Lin, J., Zhang, X., Meng, J. and Liu, J., “Photonic crystal fiber SPR refractive index sensor based on Au and TiO2 coatings”, Optics Communications, vol. 578, pp. 131512, Apr. 2025. https://doi.org/10.1016/j.optcom.2025.131512
[12] Rifat, A. A., Hasan, M. R., Ahmed, R., & Butt, H. “Photonic crystal fiber-based plasmonic biosensor with external sensing approach”, Journal of Nanophotonics, vol. 12, no. 1, pp. 012503-012503, Jan. 2018. https://doi.org/10.1117/1.JNP.12.012503
[13] Bahloul, L., Ferhat, M. L., Haddouche, I., & Cherbi, L. “A high-resolution refractive index sensor of partially cleaved PCF based on surface plasmon resonance”. Journal of Optics. pp. 1-9, Jun. 2022. https://doi.org/10.1007/s12596-021-00795-8
[14] Liu C, Shen T, Liang H, Chen JJ, Yang T. “Surface plasmon resonance refractive index sensor based on photonic crystal fiber with silver film and titanium dioxide film”, In 2021 IEEE 6th Optoelectronics Global Conference (OGC) 2021 Sep 15, (pp. 47-51). IEEE. doi: 10.1109/OGC52961.2021.9654350.
[15] Pravesh R, Kumar D, Pandey BP, Chaudhary VS, Kumar S. “Design and analysis of a double D-shaped dual core PCF sensor for detecting biomolecules in the human body”, IEEE Sensors Journal, vol. 24, no. 2, pp. 14159-14166, Mar. 2024. doi: 10.1109/JSEN.2024.3380095.
[16] Divya J, Selvendran S, Raja AS, Borra V. “A Novel Plasmonic Sensor Based on Dual-Channel D-Shaped Photonic Crystal Fiber for Enhanced Sensitivity in Simultaneous Detection of Different Analytes”, IEEE Transactions on NanoBioscience. vol. 23, no. 1, pp. 127-139, Jul 2023. doi: 10.1109/TNB.2023.3294330.
[17] Mittal S, Saharia A, Ismail Y, Petruccione F, Bourdine AV, Morozov OG, Demidov VV, Yin J, Singh G, Tiwari M, Kumar S. “Design and performance analysis of a novel hoop-cut SPR-PCF sensor for high sensitivity and broad range sensing applications”, IEEE Sensors Journal. vol. 24, no. 3, pp. 2697-2704, Feb. 2024. doi: 10.1109/JSEN.2023.3339813.
[18] Mukhopadhyay AK, Sarkar S, Mukherjee S, Das NR. “Optimization and characterization of a PCF-based SPR sensor for enhanced sensitivity and reliability in diverse chemical and biological applications”, Journal of the Optical Society of America B. vol. 42, no. 1, pp. 97-104, Dec 2024. https://doi.org/10.1364/JOSAB.537519
[19] Nagasaki, A., Saitoh, K. and Koshiba, M., “Polarization characteristics of photonic crystal fibers selectively filled with metal wires into cladding air holes”, Optics express, vol. 19, no. 4, pp.3799-3808, Feb. 2011.
https://doi.org/10.1364/OE.19.003799
[20] Khalil AE, El-Saeed AH, Farag MA, Hashish ME, Roshdi M, Hameed MF, Azab MY, Obayya SS. “Highly sensitive photonic crystal fiber biosensor based on alternative plasmonic material”, InNanophotonics VII, . vol. 10672, pp. 102-108, SPIE. May 2018. https://doi.org/10.1117/12.2306300
[21] Gupta, B.D. and Verma, R.K., “Surface plasmon resonance‐based fiber optic sensors: principle, probe designs, and some applications”, Journal of sensors, p. 979761, Aug. 2009. https://doi.org/10.1155/2009/979761
[22] Das A, Huraiya MA, Tabata H, Ramaraj SG. “Ultra-sensitive refractive index detection with gold-coated PCF-based SPR sensor”, Talanta Open. vol. 10, pp. 100384, 2024 Dec 2024. https://doi.org/10.1016/j.talo.2024.100384
[23] Majeed MF, Ahmad AK. “Design and analysis of a high sensitivity open microchannel PCF-based surface plasmon resonance refractometric sensor”, Optical Materials. vol. 147, pp. 147:114617, Jan 2024. https://doi.org/10.1016/j.optmat.2023.114617
[24] Hassan AA, Nafiz AA, Mahmud RR, Nayan MF, Salimullah SM. “Investigation of dual plasmonic material integrated wrench-shaped PCF sensor with broadband resonance for cancer cell & chemical detection”, Optik. vol. 318, pp. 318:172092, Dec 2024. https://doi.org/10.1016/j.ijleo.2024.172092
[25] Meng, F., Wang, H., & Fang, D. “Research on D-shape open-loop PCF temperature refractive index sensor based on SPR effect”. IEEE Photonics Journal, vol. 14, no. 3, pp. 1-5, Apr. 2022. doi: 10.1109/JPHOT.2022.3166822.
[26] Sorathiya, V., Lavadiya, S., Faragallah, O. S., Eid, M. M., & Rashed, A. N. Z. “D shaped dual core photonics crystal based refractive index sensor using graphene–titanium–silver materials for infrared frequency spectrum”, Optical and Quantum Electronics, vol. 54, no. 5, pp. 290, May 2022. https://doi.org/10.1007/s11082-022-03700-0
[27] Zhang KK, Wang YY, Wang Q, Wang HY, Qian YZ, Zhang DY, Xue YY, Li S, Zhang L. “Sensitive monitoring of refractive index by surface plasmon resonance (SPR) with a gold α-iron (III) oxide thin film. Instrumentation Science & Technology”, vol. 51, no. 5, pp. 558-573, Sep 2023. https://doi.org/10.1080/10739149.2023.2180030