Crocus sativus (Iranian saffron) is a widely consumed spice that has been historically attributed to various therapeutic properties. It is commonly used as a food colorant and flavoring agent in the food industry. Encapsulating spices using nanoemulsions can enhance properties such as stability and antibacterial activity. In this study, we developed a C. sativus nanoemulsion using ultrasonication. Toxicological assessment is imperative for validating the incorporation of spice nanoemulsions into foods. Therefore, the aim of this study was to evaluate the potential acute oral toxicity of this nanoemulsion in albino rats. All assessments were conducted using a single prototype batch representative of projected human exposure levels. Results indicated no treatment-related mortalities or statistically significant changes in food or water intake. Additionally, no gross abnormalities were observed in vital organs upon macroscopic examination at doses exceeding the projected human intake. Overall, this nanoemulsion demonstrated a satisfactory acute oral toxicity profile under the conditions tested. تفاصيل المقالة

Price return and P/E are two interesting factors for a lot of investors; The Bohmian quantum mechanics used referring to the time correlation of return and P/E of the stock market under consideration. In this study, we extend the quantum potential concept to determine the behaviour of P/E and also price return in two different industry of Tehran stock market during a time interval of April. 2008 to march 2019. The obtained results show that the quantum potential behaves in the same manner for P/E and price return, also confines the variations of the P/E and price return into a specific domain. Furthermore, a joint quantum potential as a function of return and P/E is derived by the probability distribution function (PDF) constructed by the real data of a given market. It serves as a suitable instrument to investigate the relationship between these variables. The resultant PDF and the corresponding joint quantum potential illustrate that where we have light points in joint quantum potential chart, the probability of those amount of P/E and price return are more than other points. In addition, because of the rectangular shape of the joint quantum potential chart we can say that these two variables behave as two independent variables in the Market. تفاصيل المقالة