Modelling and Control of Mutation Dynamics of the Cancer Cells Employing Chemotherapy
الموضوعات :
Hami Tourajizadeh
1
,
zahra zarandi
2
,
zakie farbodi
3
,
ehsan sadeghi
4
1 - Department of Mechanical Engineering, Faculty of engineering,
University of Kharazmi, Tehran, Iran
2 - Department of Mechanical Engineering, Faculty of engineering,
University of Kharazmi, Tehran, Iran
3 - Department of Mechanical Engineering, Faculty of engineering,
University of Kharazmi, Tehran, Iran
4 - Departeman of Electrical Engineering, Sistan and Baluchestan University,
Zahedan, Iran
تاريخ الإرسال : 25 السبت , جمادى الأولى, 1442
تاريخ التأكيد : 08 الثلاثاء , رمضان, 1442
تاريخ الإصدار : 28 الثلاثاء , رجب, 1443
الکلمات المفتاحية:
Metastasis Controlling,
Dynamics of mutation,
Cancer Modelling,
Stem-cells,
ملخص المقالة :
In this paper, the analytic model of the mutation dynamics related to the cancer cells which is under the control of chemotherapy is developed and its corresponding metastasis is controlled using chemotherapy method. The progress of a cancer tumours is contributed to two main factors including metastasis and mutation. It is observed that controlling the metastasis dynamic without considering the mutation phenomenon is doomed to fail. In this paper, the mathematical model of the cancer dynamic is improved considering the mutation of the stem cells and the effect of chemotherapy injection as the corresponding controlling signal is investigated in the extracted state space. Controlling the cancer growth and its mutation process is accomplished here using PID controller and State Feedback Control (SVFC) method. It is shown that by the aid of the proposed model of this paper, not only the number of the cancer cells can be converted to zero, but also the mutation process can be blocked since the feedback of the mutated cells are also engaged in the state space of the system. Verification of the model is conducted by the aid of simulation in the MATLAB and comparing the results with previous studies.
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