The Effect of Probiotic Yogurt on Immune System in Systemic Lupus Erythematosus- A Triple-blind, Randomized and Controlled trial
الموضوعات :
راضیه بنکی
1
,
Tahereh Faezi
2
,
Ahmad Esmaeilzadeh
3
,
Mahdi Mahmoudi
4
,
Elham farhadi
5
,
Majid Alikhani
6
1 - Department of Food Science and Technology, Faculty of Biological Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran
2 - Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran
3 - . Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences
4 - Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran
5 - Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran
6 - Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran
الکلمات المفتاحية: Autoantibodies, Interferon Alfa, Inflammatory factors, Probiotic, Systemic lupus erythematosus,
ملخص المقالة :
Objective:
Systemic lupus erythematosus (SLE) is an autoimmune multisystem disease. The pathogenesis of SLE is multifactorial, and gut microbiota is one of the important factors in SLE pathogenesis. This research aims to evaluate the impact of probiotic yogurt on autoantibodies, inflammatory markers, and cytokines in SLE patients.
Methods:
In this three-blind, randomized controlled trial, thirty-three lupus patients were divided into two groups. The case group received 200 g of probiotic yogurt, and the control group was given 200 g of simple yogurt for 13 weeks. The patients had SLEDAI ≤6 and were on a stable dose of immunosuppressant in the last 3 months, Demography measurements, Blood sampling, and biochemical measurements were analyzed before and after the intervention.
Results:
The level of autoantibodies such as anti-dsDNA did not change significantly by probiotic yogurt (P=0.733), while anti-SSA increased significantly in the control group (P=0.046). The level of ESR decreased in the cases group (P=0.067), while it increased in the control group (P=0.833), but the difference was not significant. About the effect of probiotic yogurt on IFNα as the main cytokine in SLE, it decreased in the cases group (P=0.809) while it increased in the control group (P=0.067), but the difference was not significant. The probiotic and placebo groups at the baseline demographic and clinical features did not differ significantly.
Conclusions: Probiotic yogurt consumption in SLE patients led to a decrease in IFNα and ESR non-significantly.
This study was registered in the Iranian Registry of Clinical Trials (ID: IRCT20240821062833N1).
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