Mehrzad Moghadasi Articles List

Open Access Article

1 - Effects of instability versus high-volume resistance training on thigh muscle cross-sectional area and hormonal adaptations
Nooshin Mehrpuya Mehrzad Moghadasi

Introduction: Instability resistance training (IRT) is a combination of unique training movements aimed at improving strength, endurance, coordination, flexibility, power, and core stability within a single workout. The aim of present study was to comparison the effect More

Introduction: Instability resistance training (IRT) is a combination of unique training movements aimed at improving strength, endurance, coordination, flexibility, power, and core stability within a single workout. The aim of present study was to comparison the effect of instability vs. high-volume resistance training (HVRT) on thigh muscles hypertrophy and hormonal adaptations. Material & Methods: Based on physical health screening, twenty middle-aged men (aged: 26.5 ± 3.6 years; ± SD) selected as the subject. The subjects divided into two groups randomly: HVRT group (n=10) or IRT group (n=10). The subjects in the HVRT group were performed biceps brachii, triceps, chest press, lat pull down, side lateral raise, leg press, dead lift, squat, hamstring and calf sitting with 6 to 10 RMs in 4 sets and 1 min rest between sets for 8 weeks. The subjects in the IRT group were performed total resistance exercise (TRX) suspension training with 10 rep in 2 sets and 20 second rest between the sets for 8 weeks. Paired-sample t-test, independent- sample t-test, wilcoxon and Mann-witney U teases were use for data analyzing. Results: The results indicated that quadriceps and total thigh muscles cross-sectional area (CSA) were increased after two types of resistance training (P<0.05) and hamstrings CSA was increased only after HVRT method. The data indicated that growth hormone (GH) and testosterone concentration and testosterone/cortisol ratio were increased after HVRT and IRT methods (P<0.05), however for cortisol levels no significant changes were observed. Conclusions: In conclusion, it seems that instability and high volume resistance training-induced changes in anabolic hormones contribute in thigh muscles hypertrophy in untrained men. Manuscript profile

Open Access Article

2 - Aerobic exercise is a feasible intervention for delaying disease progression in Alzheimer’s disease
Fatemeh Akbari Mehrzad Moghadasi Sirus Farsi Mohammad Amin Edalatmanesh

Introduction: Alzheimer’s disease (AD) is a chronic neurodegenerative disease that is characterized by a gradual loss of memory and cognitive function. Tau hyperphosphorylation and aggregation is major proximal causes of neuron loss in AD pathogenesis. Physical ex More

Introduction: Alzheimer’s disease (AD) is a chronic neurodegenerative disease that is characterized by a gradual loss of memory and cognitive function. Tau hyperphosphorylation and aggregation is major proximal causes of neuron loss in AD pathogenesis. Physical exercise may be an important adjunct to pharmacological treatment of AD, but the effects of aerobic exercise on tau gene expression are not well known. Thus, the purpose of present study was to determine the effects of aerobic exercise on tau gene expression in rats with trimethyltin (TMT) model of AD. Material & Methods: In this experiment, Thirty tow mature Sprague-dawley male rats were subjected to Alzheimer’s disease through intraperitoneally injection of 8 mg/kg TMT and then were divided into (1) control, (2) Alzheimer-infected control group, (3) endurance training, and (4) sham to study the impact of the disease on the variables. The rats in the endurance training group ran on a rat treadmill with the speed of 15 to 20 meters per minute for 15 to 30 minutes in each session, 3 times a week for 8 weeks. To analyze the results of the tests, one-way ANOVA and Tukey post hoc test were run using SPSS. Results: The results indicated that TMT injection increases the tau gene expression in the Alzheimer-infected control group. No significant differences were observed between sham and control groups. TMT rats had increased levels of tau gene expression that were significantly ameliorated by exercise (P<0.05). Conclusions: Our results suggest that aerobic exercise is a feasible intervention for delaying disease progression in AD. Manuscript profile

Open Access Article

3 - Effects of Heavy Duty versus traditional resistance training on thigh muscle cross-sectional area
Javad Mokaram Bakhtajerdi Mehrzad Moghadasi

Introduction: Heavy Duty resistance training (HD) is a new method that might improve muscle strength and hypertrophy. The effect of this method on thigh muscle hypertrophy is not well-known. The purpose of the present study was to examine the effects of HD versus tradit More

Introduction: Heavy Duty resistance training (HD) is a new method that might improve muscle strength and hypertrophy. The effect of this method on thigh muscle hypertrophy is not well-known. The purpose of the present study was to examine the effects of HD versus traditional resistance training (TRT) on thigh muscle cross-sectional area (CSA). Material & Methods: Twenty untrained healthy men (age: 25.6 ± 2.0 mean ± SD) volunteered to participate in this study. The subjects were divided into HD group (n=10) or TRT group (n=10) randomly. The subjects in HD and TRT executed five resistance exercises selected to stress the thigh muscle groups in the following order: leg press, squat, leg extension, prone leg curl, and dead lift. HD and TRT consisted of 50-60 min of station weight training per day, 3 days a week, for 8 weeks. TRT training was performed in 5 stations and included 4 sets with 6-12 maximal repetitions at 70-80% of 1-RM in each station with 2-3 minute of rest. HD training was performed in 5 stations and included 4 sets with 6-10 maximal repetitions at 70% of 1-RM in each station with 10 second of rest. Thigh muscle CSA and grow hormone (GH) were measured before and after the intervention. Results: The results showed that maximum strength in each station was increased after HD and TRT (P<0.05). Thigh muscle CSA also was increased after HD and TRT; however the increase in thigh muscle CSA was higher in HD than TRT. For GH no significant differences were observed after the HD and TRT methods. Conclusions: In summary, HD method is better than TRT method for thigh muscle CSA however no significant differences were found for GH level after these resistance training methods. Manuscript profile

Open Access Article

4 - Comparison the effect of short vs. long rest period between the sets in resistance training on testosterone to cortisol ratio
Tanaz Abbasi Mehrzad Moghadasi

Introduction: There is a little information about the effect of rest period length on hormonal adaptation. The purpose of this study was to investigate the effect of short vs. long rest period between the sets in resistance training on testosterone to cortisol ratio (Ts More

Introduction: There is a little information about the effect of rest period length on hormonal adaptation. The purpose of this study was to investigate the effect of short vs. long rest period between the sets in resistance training on testosterone to cortisol ratio (Ts /‪ Co ratio). Material & Methods: Sixteen experienced, weight trained men volunteered to participate in the study. Subjects were randomly assigned to either a short (30 second; P30) or long (120 second; P120) rest period group. During the first 2 weeks of training, 3 sets of 10-12 repetition maximum (RM) with 120 second rest intervals between sets and exercises (hamstring with machine, squat, dead lift and leg press) were performed by both groups. During the next 6 weeks of training, the P120 group trained using 120 second between sets and exercises (4 sets of 8-10RM), and the P30 group trained using 30 second between sets and exercises as the 6 weeks of training progressed (4 sets of 8-10RM). Blood samples were taken at baseline, immediately and 30 min after the last session of training for measurement serum Ts and Co concentrations. Results: The results indicated that Ts /‪ Co ratio had tendency to increase immediately after last session of resistance training in P30 and P120 group however no significant differences were observed between these groups. The Ts /‪ Co ratio at post exercise was higher but not significance in the P120 in compare to the P30. Conclusion: Our results suggested that there is no significant difference in Ts /‪ Co ratio after short or long rest period between the sets in resistance training. Manuscript profile

Open Access Article

5 - Plasma leptin and adiponectin concentrations in postmenopausal women with breast cancer following aerobic exercise
Mehrzad Moghadasi Reza Nouri Laleh Karami Bonari Shima Gholamalishahi Mohadeseh Nematollahzadeh Mahani

Introduction: Breast cancer is the most common cancer in postmenopausal women. Exercise affects breast cancer risk and outcomes, but little is known about the mechanisms through which this effect may be mediated. The purpose of this study was to investigate the effect o More

Introduction: Breast cancer is the most common cancer in postmenopausal women. Exercise affects breast cancer risk and outcomes, but little is known about the mechanisms through which this effect may be mediated. The purpose of this study was to investigate the effect of 12 weeks aerobic exercise on plasma leptin and adiponectin in postmenopausal women with breast cancer. Material & Methods: Nineteen postmenopausal women with breast cancer (aged: 55 ± 2.7 years; ± SD) volunteered to participate in this study. The subjects were randomly assigned to training group (n=11) or control group (n=8). Subjects in the experimental group performed 12 weeks of an exercise program which consisted of 25 to 45 minutes of walking with an intensity of 45-65% of target heart rate, three times a week. Results: Body mass and BMI decreased (P<0.05) after 12 weeks exercise training compared to the control group, while no significant change in body fat percent and WHR were found. Plasma leptin decreased (P<0.05) and plasma adiponectin increased (P<0.05) in response to 12 weeks aerobic exercise training compared to the control group, while insulin resistance determined by HOMA-IR did not change in the training group. Conclusions: In summary, 12 weeks aerobic exercise increase plasma adiponectin and decrease plasma leptin in postmenopausal women with breast cancer. Manuscript profile

Open Access Article

6 - Spark Motor Program reduced oxidative stress in boys with Down syndrome
Atefeh Jan Mohammadi Mehrzad Moghadasi

Introduction: Oxidative stress (OS) level is higher in individuals with Down syndrome (DS). Malondialdehyde (MDA) is a marker for lipid peroxidation and the effect of exercise training on MDA in DS patients is not well known. The aim of this study was to examine the eff More

Introduction: Oxidative stress (OS) level is higher in individuals with Down syndrome (DS). Malondialdehyde (MDA) is a marker for lipid peroxidation and the effect of exercise training on MDA in DS patients is not well known. The aim of this study was to examine the effects of selected Spark Motor Program on MDA in boys with DS. Material & Methods: Twenty Down syndrome boys aged between 10~14 participated in this study as the subjects. The subjects were randomly divided into experimental group (n=10) or control group (n=10). The experimental group was performed selected Spark Motor Program 3 days a week for 8 weeks. MDA concentration was measured before and 48h after the intervention. Results: The results showed that MDA decreased after 8 weeks selected experimental in compare to the control group. Conclusions: In summary, Spark Motor Program that selected in this study decreases MDA of boys with DS. Manuscript profile

Open Access Article

7 - Immune responses to exercising in a hot environment in soccer players
Koorosh Mardani Mehrzad Moghadasi Eskandar Rahimi

Introduction: Hot temperature and exercise independently lead to metabolic changes in the human body and depress the immune system. Changes on immunoglobulin A (IgA) and cortisol in response to an intensive exercise in hot environment especially in the soccer players ar More

Introduction: Hot temperature and exercise independently lead to metabolic changes in the human body and depress the immune system. Changes on immunoglobulin A (IgA) and cortisol in response to an intensive exercise in hot environment especially in the soccer players are not well known. Thus, the aim of this study was to investigate the effect of an intensive exercise in thermoneutral and hot conditions on salivary IgA (s-IgA) and cortisol concentrations in soccer players. Material & Methods: Twelve elite male soccer players (age, 21 to 34 years) participated in this study as the subject. Total unstimulated saliva samples were collected before, immediately and 30 min after the exercise training in thermoneutral (HT: 20 ○C and 20% RH) and hot environments (HT: 30 ○C and 20% RH). Water was available ad-libitum. Results: s-IgA and cortisol levels were increased after an intensive exercise at both environments and their levels were significantly higher than baseline until 30 min after the exercise (P<0.05). Total protein concentration was increased 30 min after the exercise in the heat (P<0.05), however no significant differences were observed between two occasions. Salivary flow rate was not affected by 2 conditions or differed at any time-point post-exercise. No significant differences were observed in s-IgA and cortisol levels between two environments. Conclusions: In conclusion, enduring hot temperature intensified stressful responses elicited by intensive exercise. This study advocates that hot temperature deteriorates exercise performance under exhaustive stress and effort conditions in soccer players. Manuscript profile

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List of Articles Mehrzad Moghadasi