List of Articles Mohammad Amin Edalatmanesh

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  1 - Aerobic exercise is a feasible intervention for delaying disease progression in Alzheimer’s disease
  Fatemeh Akbari Mehrzad Moghadasi Sirus Farsi Mohammad Amin Edalatmanesh
  Introduction: Alzheimer’s disease (AD) is a chronic neurodegenerative disease that is characterized by a gradual loss of memory and cognitive function. Tau hyperphosphorylation and aggregation is major proximal causes of neuron loss in AD pathogenesis. Physical ex More

  Introduction: Alzheimer’s disease (AD) is a chronic neurodegenerative disease that is characterized by a gradual loss of memory and cognitive function. Tau hyperphosphorylation and aggregation is major proximal causes of neuron loss in AD pathogenesis. Physical exercise may be an important adjunct to pharmacological treatment of AD, but the effects of aerobic exercise on tau gene expression are not well known. Thus, the purpose of present study was to determine the effects of aerobic exercise on tau gene expression in rats with trimethyltin (TMT) model of AD. Material & Methods: In this experiment, Thirty tow mature Sprague-dawley male rats were subjected to Alzheimer’s disease through intraperitoneally injection of 8 mg/kg TMT and then were divided into (1) control, (2) Alzheimer-infected control group, (3) endurance training, and (4) sham to study the impact of the disease on the variables. The rats in the endurance training group ran on a rat treadmill with the speed of 15 to 20 meters per minute for 15 to 30 minutes in each session, 3 times a week for 8 weeks. To analyze the results of the tests, one-way ANOVA and Tukey post hoc test were run using SPSS. Results: The results indicated that TMT injection increases the tau gene expression in the Alzheimer-infected control group. No significant differences were observed between sham and control groups. TMT rats had increased levels of tau gene expression that were significantly ameliorated by exercise (P<0.05). Conclusions: Our results suggest that aerobic exercise is a feasible intervention for delaying disease progression in AD. Manuscript profile
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  2 - The effect of swimming exercise and hesperidin on hippocampal cell damage after pentylenetetrazol induced prenatal seizures in rats
  Samaneh Rafiei Shaghayegh Keshavarzi Mehdi Noura Mohammad Amin Edalatmanesh
  Introduction: Prenatal seizures cause the production of free radicals in fetal nervous system and selective neuronal death of hippocampus. The purpose of this study is to evaluate the effect of swimming exercise (EX) and hesperidin administration (HES) as a potent antio More

  Introduction: Prenatal seizures cause the production of free radicals in fetal nervous system and selective neuronal death of hippocampus. The purpose of this study is to evaluate the effect of swimming exercise (EX) and hesperidin administration (HES) as a potent antioxidant on hippocampal cell damage in rats following pentylenetetrazol (PTZ) induced prenatal seizures.Materials & method: In this experimental study, infants from 20 females pregnant Wistar rats were randomly put in 5 groups of control, PTZ+NS, PTZ+HES, PTZ+EX, PTZ+HES+EX. From the 14th day of pregnancy, animals were exposed to repeated PTZ injection (50mg/kg, intraperitoneal) for 5 consecutive days. From the first day of pregnancy to the term delivery, swimming exercise training with moderate intensity and 3 times a week and daily hesperidin gavage for 3 weeks was done. Finally, the hippocampal cell density was evaluated in different hippocampus areas of male infants at postnatal day 30.Results: The increase of cell damage and decrease of cellular density in different regions of hippocampus was seen in PTZ+NS group than the control group (p<0.05). Meanwhile, the increase of hippocampal cellular density and decrease of mortality of pyramidal neurons was also observed in PTZ+HES+EX group compared to PTZ+NS group (p<0.05).Conclusions: The interaction of swimming exercise training and hesperidin have neuroprotective effects in rats’ prenatal seizure models. Manuscript profile