List of Articles Seyed Mahdi Rezayat Sorkhabadi

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  1 - The Investigation of the Toxicity of Palladium Nanoparticles on Human Lymphocyte
  maryam zivari fard majid sharifi arian shojaei Seyed Mahdi Rezayat seyyedeh elaheh mousavi Mojtaba Falahati
  10.22034/jna.2020.1893038.1188
  Palladium nanoparticles (Pd-NPs) have various applications in industries, such as: Biomedicine, Sewage treatment, Electronics, and Catalytic processes. Different studies on NP have shown that they have negative impacts on different cell categories in vitro. Despite exte More

  Palladium nanoparticles (Pd-NPs) have various applications in industries, such as: Biomedicine, Sewage treatment, Electronics, and Catalytic processes. Different studies on NP have shown that they have negative impacts on different cell categories in vitro. Despite extensive considerations, the molecular mechanism of Pd-NPs toxicity has remained elusive thus far. Therefore, in this paper, we investigated the toxicity of Pd-NPs by evaluating their effects on human lymphocyte. Blood lymphocyte cells were initially isolated by ficoll solution and were exposed to Pd-NPs and Pd (II) ions. Then, we examined oxidative stress, cell cycle and apoptosis employing flow cytometry. We found the NPs administration suppressed cell growth which in turn resulted in cell apoptosis. Also, cell cycle stopped at sub G1 phase, resulting in DNA damage as well as profound ROS increase. Our results showed that Pd-NPs treatment for 24 hours led to apoptosis, oxidative stress, as well as cell cycle blockage. It is notable that Pd (II) ions induced more severe toxicity. Our findings provide valuable insights on Pd-NPs toxicity. Manuscript profile
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  2 - Green synthesis of silver nanoparticles and antioxidant activities in Bunium persicum (Boiss.) B.Fedtsch. seeds extract .
  Nastaran Kazemivash Ahmad Majd Sayyeh Jafari Marandi Seyed Mahdi Rezayat
  10.22034/jna.2018.559599.1069
  In this study, the antioxidant activity and green synthesis of silver nanoparticles of ethanolic extracted from the seeds of Bunium persicum (Boiss.) B.Fedtsch. was investigated for a first time. B.persicum is a local plant of Iran and the Study of antioxidant activity More

  In this study, the antioxidant activity and green synthesis of silver nanoparticles of ethanolic extracted from the seeds of Bunium persicum (Boiss.) B.Fedtsch. was investigated for a first time. B.persicum is a local plant of Iran and the Study of antioxidant activity in this plant performed using DPPH method and shows the notable Results in scavenging the free radicals. Antioxidant activity of extract checked in comparison to BHT. IC50 of B.persicum respectively was 1000 mg/mL that reveals notable antioxidant effect. Another experiment performed on green synthesis of silver nanoparticles in this plant extract. Green synthesis of silver nanoparticles in B. persicum confirmed by the FT_IR, scanning electron microscopy (SEM) , UV-vis spectroscopy and EDX spectra . Ag NPs were almost spherical in shape with an average diameter of 51 nm. Results showed significant antioxidant effects that cause the formation of spherical silver nanoparticles with nearly homological size in this plant that can be used as the basis of medical studies in the future. Manuscript profile
• Open Access Article
  • Abstract Page
  • Full-Text
  
  3 - The Investigation of the Toxicity of Palladium Nanoparticles on Human Lymphocyte
  Maryam Zivari fard Majid Sharifi Arian Shojaei Seyed Mahdi Rezayat Seyyedeh Elaheh Mousavi Mojtaba Falahati
  10.22034/jna.2021.685599
  Palladium nanoparticles (Pd-NPs) have various applications in industries, such as:Biomedicine, Sewage treatment, Electronics, and Catalytic processes. Differentstudies on NP have shown that they have negative impacts on different cellcategories in vitro. Despite extensi More

  Palladium nanoparticles (Pd-NPs) have various applications in industries, such as:Biomedicine, Sewage treatment, Electronics, and Catalytic processes. Differentstudies on NP have shown that they have negative impacts on different cellcategories in vitro. Despite extensive considerations, the molecular mechanismof Pd-NPs toxicity has remained elusive thus far. Therefore, in this paper,we investigated the toxicity of Pd-NPs by evaluating their effects on a humanlymphocyte. Blood lymphocyte cells were initially isolated by ficoll solution andwere exposed to Pd-NPs and Pd (II) ions. Then, we examined oxidative stress, cellcycle, and apoptosis employing flow cytometry. We found the NPs administrationsuppressed cell growth, which in turn resulted in cell apoptosis. Also, the cell cyclestopped at the sub G1 phase, resulting in DNA damage as well as profound ROSincrease. Our results showed that Pd-NPs treatment for 24 hours led to apoptosis,oxidative stress, as well as cell cycle blockage. It is notable that Pd (II) ions inducedmore severe toxicity. Our findings provide valuable insights on Pd-NPs toxicity. Manuscript profile
• Open Access Article
  • Abstract Page
  • Full-Text
  
  4 - Green synthesis of silver nanoparticles and antioxidant activities in Bunium persicum (Boiss.) B.Fedtsch. seeds extract
  Nastaran Kazemivash Ahmad Majd Sayeh Jafari Marandi Seyed Mahdi Rezayat
  10.22034/jna.2018.543690
  In this study, the antioxidant activity and green synthesis of silver nanoparticles of ethanolic extracted from the seeds of Bunium persicum (Boiss.) B.Fedtsch was investigated for the first time. B.persicum is a local plant of Iran and the antioxidant activity of this More

  In this study, the antioxidant activity and green synthesis of silver nanoparticles of ethanolic extracted from the seeds of Bunium persicum (Boiss.) B.Fedtsch was investigated for the first time. B.persicum is a local plant of Iran and the antioxidant activity of this plant was studied using the DPPH method and shows notable results in scavenging the free radicals. Antioxidant activity of extract checked in comparison to BHT.IC50 of B.persicum respectively was 1000mg/mL; revealing a notable antioxidant effect. Another experiment was performed on green synthesis of silver nanoparticles in this plant extract. Green synthesis of silver nanoparticles in B. persicum was confirmed by the Fourier transforms infrared spectroscopy (FTIR), scanning electron microscopy (SEM),UV-Vis spectroscopy, Energy dispersive X-ray diffraction analysis (EDX) and the X-ray diffraction (XRD). Ag NPs were almost spherical in shape, with an average diameter of 51 nm. Results showed significant antioxidant effects that cause the formation of spherical silver nanoparticles with nearly homological size in this plant and can be used as the basis of medical studies in the future. Manuscript profile