Ring-opening polymerization was used in this study to intelligent new novel drug natural polymer which has been prepared from grafted copolymerization of Casein with phthalic anhydride (A1)by using ring-opening polymerization. Then the prepared (A1)was bonded with different such as procaine, salbutamol, amoxicillin, and paracetamol through the ring opening of phthalic anhydride to produce a copolymer of casein –g-phthalic anhydride compound [A1] and reacted with SOCl2 in acetone. compound [A1] reaction with different drugs salbutamol, amoxicillin, paracetol, and procaine. Spectral evidence established the structure of synthesized compounds: UV-Visble, FT-IR, and 1HNMR, Thermo gravimetric analysis was carried out y TGA and DSC. The controlled drug release was studied by different pH values at 37°C. The sustained release was observed as pH-sensitive in specific sites with controlling release with suitable concentration. it was found high in basic medium about 90%. antibacterial activity against several bacterial strains i.e. gram-positive bacteria: Staphylococcus aureus and Bacillus subtitles gram-negative bacteria: Pseudomonas aeruginosa and Escherichia coli.
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