The interaction of acetaminophen drug by chitosan-capped gold Nanoparticles was investigated using a resonance Rayleigh scattering (RRS) spectroscopic technique. The standard deviation of (1.1 %), and detection limit of the method (0.5 ng mL-1 in time 6 min, 325 nm) wer More
The interaction of acetaminophen drug by chitosan-capped gold Nanoparticles was investigated using a resonance Rayleigh scattering (RRS) spectroscopic technique. The standard deviation of (1.1 %), and detection limit of the method (0.5 ng mL-1 in time 6 min, 325 nm) were obtained for sensor level response chitosan-capped AuNPs with (97%) confidence evaluated. The results indicated that this method had good selectivity in the presence of coexisting compounds. The scattering intensity (ΔIRRS) was linearly dependent on acetaminophen drug concentration over the range (0.5 to 200.0 ng mL-1) with a determination coefficient (r) of 0.998. This method could be suitably used for analysis of acetaminophen drug in pharmaceutical, human fluid, and other drugs, and hospital samples.
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