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Open Access Article
1 - Preparation and Characterization of Magnetic Gelatin-Polyvinyl Alcohol Hydrogel for using in the Release of Furosemide Drug
Benyamin Masoumi Masoud MokhtaryThe magnetic gelatin-polyvinylalcohol hydrogel was prepared using K2S2O8 in aqueous media inthe presence of N,N′-methylenebisacrylamide, and Fe3O4 nanoparticles. The magnetic gelatinpolyvinylalcohol (Fe3O4/PVA-gelatin) hydrogel was characterized by FT-IR, SEM, and MoreThe magnetic gelatin-polyvinylalcohol hydrogel was prepared using K2S2O8 in aqueous media inthe presence of N,N′-methylenebisacrylamide, and Fe3O4 nanoparticles. The magnetic gelatinpolyvinylalcohol (Fe3O4/PVA-gelatin) hydrogel was characterized by FT-IR, SEM, and EDX. Also,magnetic characterization of the synthesized Fe3O4/PVA-gelatin hydrogel was specified by avibrating sample magnetometer (VSM). Then, the loading and release of the furosemide drug wereinvestigated using magnetic gelatin-polyvinylalcohol hydrogel. The FT-IR results confirmed theformation of gelatin-polyvinyl alcohol magnetic hydrogel. The effects of temperature and pH on theloading and release of furosemide drug in gelatin-polyvinylalcohol magnetic hydrogel were studied.The gelatin-PVA magnetic hydrogel is sensitive to pH and temperature and provides the controlledrelease of furosemide. The results showed that the highest loading of the drug was achieved at roomtemperature after 6 hours. Also, the highest drug release was observed after 4 hours at 40 °C in pH= 7. Manuscript profile -
Open Access Article
2 - Production of Ethylene Glycol Diacetate Ester Using a Heterogeneous Titanium (IV) Isopropoxide Catalyst: Response Surface Methodology
Borna Bayat Kambiz Tahvildari Amin Bazyari Alireza HemmatiIn this study, the reactive batch distillation of ethylene glycol monoacetate (EGMA) and ethyleneglycol diacetate (EGDA) was investigated experimentally and numerically via the esterificationreaction of acetic acid (AA) and monoethylene glycol (MEG) in the presence of h MoreIn this study, the reactive batch distillation of ethylene glycol monoacetate (EGMA) and ethyleneglycol diacetate (EGDA) was investigated experimentally and numerically via the esterificationreaction of acetic acid (AA) and monoethylene glycol (MEG) in the presence of heterogeneoustitanium (IV) isopropoxide catalyst. Four operating parameters, including time (4-12 hr),temperature (60-100°C), the molar ratio of acetic acid to ethylene glycol (0.4-2.2 M), and catalystweight (1-5wt%), were selected to design experiments, model and optimize the process through theresponse surface methodology (RSM). By applying the central composite design (CCD) method inRSM, two linear and second-order models were proposed for the responses of MEG conversion andEGD selectivity. The response surface plots showed that the reaction temperature and time had amore significant effect on increasing the reaction yield, while the molar ratio of reactants andcatalyst weight were two critical parameters in increasing selectivity. The results of processoptimization to maximize the responses indicated that the optimum process point in the operatingrange was at 9.5 hr, the temperature of 90°C, the molar ratio of 2.92:1, and catalyst weight of 2wt%where the predicted MEG conversion and selectivity were 100% and 94.72%, respectively. TheMEG conversion reduced from 91.1% to 56.7% after using the catalyst four times. Manuscript profile -
Open Access Article
3 - Preparation of Novel Thermo-sensitive Polymer/βCD/WS2 Nano-carriers for invitro Drug Release of Tamoxifen in the Presence and Absence of Near-Infrared (NIR) Laser
Abbas Bohloli Maryam Daghighi Asli Elham Moniri Azar BagheriIn this work, two novel N-isopropylacrylamide (NIPAA)/Beta-cyclodextrin (β-CD)/WS2 and NIPAA/N, Ndimethyl acrylamide (DMAA)/WS2/βCD nanocarriers were prepared for in vitro tamoxifen drug release inthe absence and presence of Near-Infrared (NIR) laser. The char MoreIn this work, two novel N-isopropylacrylamide (NIPAA)/Beta-cyclodextrin (β-CD)/WS2 and NIPAA/N, Ndimethyl acrylamide (DMAA)/WS2/βCD nanocarriers were prepared for in vitro tamoxifen drug release inthe absence and presence of Near-Infrared (NIR) laser. The characterization of resulting nanocarriers wascarried out using X-ray diffraction (XRD), Fourier transforms infrared spectroscopy (FTIR), field-emissionscanning electron microscopy (FE-SEM), and thermogravimetric analysis (TGA). To study the effect oftemperature on drug release for chemotherapy, tamoxifen drug release was comparatively evaluated at threedifferent temperatures (25, 37, and 50°C) with pH 7.4 in the absence of a NIR laser. It was found thattamoxifen release from the synthesized nanocarriers at 50°C was significantly greater than that at 25 and37°C. To investigate the effect of laser light on drug release for chemo-photothermal therapy, the in vitrorelease tests were carried out at 37°C with a NIR laser light and with a power density of 1 W/cm2for 5 min.The increase of tamoxifen release after a laser light was 29.8% and 48.4%for NIPAA/βCD/WS2 andNIPAA/DMAA/βCD/WS2 samples, respectively. Thus, the combination of chemo/photothermal therapy hada synergistic effect on the drug release of tamoxifen. Furthermore, the total drug release ofNIPAA/DMAA/βCD/WS2 was greater than that of NIPAA/βCD/WS2 nanocarrier. Furthermore, the kineticrelease data were analyzed using Zero-order, First-order, Ritger-Peppas, and Higuchi models which followedthe zero-order kinetic release model. Also, good stability was observed for tamoxifen in the drug releasesystem. Manuscript profile -
Open Access Article
4 - Heat Treatment of Graphene Oxide/Thiourea Mixture in the Solid State and Application for Detection of Uric acid and pH Sensing
Javad Gholami Nastaran JaliliThe heat treatment of the graphene oxide/ thiourea mixture was done by the tube furnace equippedwith an argon inlet. The graphene oxide/ thiourea sample was characterized by UV–visiblespectrometry, Thermogravimetric analysis, Fourier transform infrared spectroscop MoreThe heat treatment of the graphene oxide/ thiourea mixture was done by the tube furnace equippedwith an argon inlet. The graphene oxide/ thiourea sample was characterized by UV–visiblespectrometry, Thermogravimetric analysis, Fourier transform infrared spectroscopy and X-rayphotoelectron spectroscopy. The UV–vis absorption spectra of graphene oxide was shown thecharacteristic absorbance of graphene oxide, and the Fourier transform infrared spectra showedcarboxylic acid group and thiocyanate on the surface of graphene oxide/thiourea. Thedeconvolution of X-ray photoelectron spectra showed the sulfur and nitrogen on the surface ofgraphene oxide. The peak area, the percent of carbon, oxygen, nitrogen, and sulfur of modifiedgraphene oxide based on Scofield’s relative sensitivity factor (RSF), was 73, 16, 7, and 4,respectively. The fluorescence measurements of the modified graphene oxide suspension in thedifferent pH were investigated. The alkaline solution showed the most emission intensity. Thesample was shown good interaction with uric acid in the alkaline solution compared to othersubstances, including thiamin, nicotinamide, urea, ascorbic acid, glucose, and lauric acid, based onfluorescence spectroscopy. Manuscript profile -
Open Access Article
5 - Synthesis of Pyrazolopyranopyrimidine and Dihydropyrano[2,3-c]pyrazole Derivatives using Vitamin D as an Efficient Catalyst under Green Condition
Fatemeh Mir Nourallah Hazeri Malek Taher Maghsoodlou Mojtaba LashkariAn efficient, rapid, and eco-friendly protocol for one-pot, four-component preparation ofdihydropyrano[2,3-c]pyrazole and pyrazolopyranopyrimidine derivatives has been developed usingvitamin D as an efficient catalyst. This method involves several advantages such as low MoreAn efficient, rapid, and eco-friendly protocol for one-pot, four-component preparation ofdihydropyrano[2,3-c]pyrazole and pyrazolopyranopyrimidine derivatives has been developed usingvitamin D as an efficient catalyst. This method involves several advantages such as low-cost andnon-toxic catalysts, high yields of products, simple workup, no hazardous solvent, and no need forcolumn chromatography. Manuscript profile -
Open Access Article
6 - Application of N-isocyaniminotriphenyl phosphorane for preparation of heterocyclic acrylate as a key constituent of many industrial and pharmaceutical compounds
Milad Bazaz Rastkar Bita Mohtat Gholam Bagheri Marandi Hoorieh Djahaniani2-Hydroxy pyridine undergoes a smooth reaction with electron-deficient acetylenic esters in thepresence of N-isocyaniminotriphenyl phosphorane under reflux conditions to produce theheterocyclic acrylate compounds in high yields. The acrylate structures with E/Z isomers More2-Hydroxy pyridine undergoes a smooth reaction with electron-deficient acetylenic esters in thepresence of N-isocyaniminotriphenyl phosphorane under reflux conditions to produce theheterocyclic acrylate compounds in high yields. The acrylate structures with E/Z isomers wereobtained when the reaction was performed with 4-Hydroxy pyridine and 4-Hydroxy quinazoline,the acrylate structures with E/Z isomers were obtained. All compounds have many applications inmedicinal and industrial chemistry—configuration of E/Z isomers distinguished with nuclearmagnetic resonance technique and chemical shift of olefinic proton. The method offers a simple andefficient route for preparing acrylate heterocyclic compared to the other methodologies. Thestructures of the products were deduced and supported by 1HNMR and IR spectroscopy. Manuscript profile
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