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Open Access Article
1 - Microwave-assisted Solid-phase(SPPS) and Solution-phase (SPS) Synthesis of Biological Dipeptide ((β-alanine-L histidine)
Maryam Khosravi Rahmatollah Rahimi Mahboubeh Rabbani Ebrahim SafaviPeptides have shown Promising effect as pharmaceutics with the potential to treat a widevariety of diseases. Peptides are mostly synthesized by biological technology or chemicalmethods. Solution phasepeptide synthesis (SPS) and solid phase peptide synthesis (SPPS) aretw MorePeptides have shown Promising effect as pharmaceutics with the potential to treat a widevariety of diseases. Peptides are mostly synthesized by biological technology or chemicalmethods. Solution phasepeptide synthesis (SPS) and solid phase peptide synthesis (SPPS) aretwo major chemical techniques for peptidesproduction.In this research, the synthesis ofdipeptde(β-alanine-L-histidine)wasexaminedby the both SPS and SPPS methods. Thesolution phase synthesizeswasdonebyN-phthalic anhydride as a protective group andthe solidphase using standardtert-Butyloxycarbonyl (BOC) and Fluorenylmethyloxycarbonylchloride(Fmoc).Inthe both methods,themicrowave was assisted in different steps. Themolecular structure of the dipeptide(β-alanine-L-histidine) wasdefined using differentspectrometrymethods such as:UV-Vis, FT-IR, 1HNMR and LC-Massanalysis. Manuscript profile -
Open Access Article
2 - Green Synthesis of α-Fe2O (hematite) Nanoparticles using Tragacanth Gel
Saeid Taghavi Fardood Ali Ramazani Zahra Golfar Sang Woo Jooα-Fe2O3 (hematite) nanoparticles were synthesized using tragacanth gel as biotemplate andiron chloride as the iron source by the sol-gel method. This method has many advantages suchas nontoxic, economic viability, ease to scale up, less time consuming and environm Moreα-Fe2O3 (hematite) nanoparticles were synthesized using tragacanth gel as biotemplate andiron chloride as the iron source by the sol-gel method. This method has many advantages suchas nontoxic, economic viability, ease to scale up, less time consuming and environmentalfriendly approach for the synthesis of α-Fe2O3 nanoparticles without using any organicchemicals. Nanoparticles were characterized by Fourier transform infrared (FT-IR)spectroscopy, UV-visible spectroscopy and X-ray diffraction (XRD). The powder X-raydiffraction (XRD) analysis revealed the formation of Rhombohedral phase α-Fe2O3 withaverage particle size of 21 nm. Manuscript profile -
Open Access Article
3 - Solvent Effect on the Molecular Structure, Chemical Reactivity and Spectroscopy Properties of Z-Ligustilide: A Main Active Component of Multitude Umbelliferae Medicinal Plants
Mahmoud Osanloo Reza GhiasiIn this investigation, the structural, electronic properties, 13C and 1H NMR parameters and firsthyperpolarizability of Z-Ligustilide were explored. As well, the solvent effect on structural parameters, frontier orbital energies, electronic transitions, and 13C and 1H N MoreIn this investigation, the structural, electronic properties, 13C and 1H NMR parameters and firsthyperpolarizability of Z-Ligustilide were explored. As well, the solvent effect on structural parameters, frontier orbital energies, electronic transitions, and 13C and 1H NMR parameters was illustrated based on Polarizable Continuum Model (PCM).These consequences specify that the polarity of solvents participates on the structures and spectroscopic properties of Z-Ligustilide.NBO analysis was used to examining of the hybridation of atoms, atomic charges and their second order stabilization energy within the molecule. Manuscript profile -
Open Access Article
4 - Sodium Bismuthate: An Efficient Catalyst for the One-pot Synthesis of Biologically Active Spiro[4H-pyran] Derivativesunder Solvent-free Conditions
Farzaneh Mohamadpour Malek Taher Maghsoodlou Reza Heydari Mojtaba LashkariAn efficient sodium bismuthate (NaBiO3) synthesis of biologically active spiro[4H-pyran]derivatives has been accomplished via one-pot three-condensation of isatin/acenaphthequinone, malononitrile and different reagents including 1,3-dicrbonyl compounds, α-naphthol MoreAn efficient sodium bismuthate (NaBiO3) synthesis of biologically active spiro[4H-pyran]derivatives has been accomplished via one-pot three-condensation of isatin/acenaphthequinone, malononitrile and different reagents including 1,3-dicrbonyl compounds, α-naphthol and 4-hydroxycumarin under solvent-free conditions. The notable advantages of the present procedure are: eco-friendly, environmentally benign nature,low-cost and non-toxic catalyst, simplicity of operation with no necessity of chromatographicpurification steps, short reaction times, good to high yields and solvent-free conditions. Manuscript profile -
Open Access Article
5 - Mechanical Synthesis of Zn-HKUST-1 Metal-Organic Framework and Investigation its Fluorescence Sensing Ability Toward to Detect Explosive-like Nitro aromatic Analytes Such as TNT
Mohammad Javad Taghizadeh Seyed Salman Seyed Afghahi Hossein GhasempoorMetal-Organic Framework (MOFs) are new crystalline materials which because of having propertiessuch as high porosity, optical and electrical properties, etc., have been considered in areas such as gasstorage, catalysis, pollutants removal and so on. Therefore, in order MoreMetal-Organic Framework (MOFs) are new crystalline materials which because of having propertiessuch as high porosity, optical and electrical properties, etc., have been considered in areas such as gasstorage, catalysis, pollutants removal and so on. Therefore, in order to develop these compounds andtheir use in this study, in this work, Zn-HKUST-1 metal-organic framework was synthesized by fastand also environmentally friendly physical mixing (grinding by hand) method. To identify productsspectroscopy methods such as FT-IR and PXRD were employed. The sensing ability of this frameworkto detect explosive-like nitroaromatic analyets such as nitrobenzene, 1,3-dinitrobenzene and TNT wastested. The results showed that the sensitivity of Zn-HKUST-1 to TNT is more than two other analytesand this metal-organic framework can be effective in detecting explosives such as TNT. Alsoultrasound assisted synthesis (sonochemical) of this framework and effect of initial reagentsconcentration and power generating ultrasonic apparatus on the size and shape of the products wereinvestigated. Manuscript profile -
Open Access Article
6 - Synthesis of Tetrahydrobenzo[a]xanthene-11-one Derivatives Using ZrO2–SO3H as Highly Efficient Recyclable Nano-catalyst
Ahmad Nakhaei Sepideh YadegarianThe catalytic effect of Zirconia Sulfuric Acid (ZrSA) nanoparticle which is synthesized from thereaction of ZrO with chlorosulfonic acid has been investigated in the synthesis oftetrahydrobenzo[a]xanthene-11-ones by one-pot three-component reaction of β-naphthol,ar MoreThe catalytic effect of Zirconia Sulfuric Acid (ZrSA) nanoparticle which is synthesized from thereaction of ZrO with chlorosulfonic acid has been investigated in the synthesis oftetrahydrobenzo[a]xanthene-11-ones by one-pot three-component reaction of β-naphthol,aromatic aldehydes, and dimedone. Different reaction conditions were studied in the presence ofZrSA nanoparticle as catalyst. The results showed that ZrSA exhibited high catalytic activitytowards the synthesis of tetrahydrobenzo[a]xanthene-11-ones, with the desired products beingformed in high yields. Furthermore, the catalyst was recyclable and could be reused at least threetimes without any discernible loss in its catalytic activity. Overall, this new catalytic method forthe synthesis of tetrahydrobenzo[a]xanthene-11-ones provides rapid access to the desiredcompounds under solvent-free conditions at 110 °C following a simple work‐up procedure, andavoids the use of harmful organic solvents. This method therefore represents a significantimprovement over the methods currently available for the synthesis oftetrahydrobenzo[a]xanthene-11-ones. Manuscript profile -
Open Access Article
7 - A Synthetic Approach for Evaluation of Cytosinediazonium Susceptibility
Kamahldin Haghbeen Shima Rezaeian Mehdi Bakavoli Fatemeh MiraziziReaction of a nucleobase with nitrosonium ion leads to its diazotization. Due to the instability,the nucleobase-diazonium assumingly falls in dediazotization and successive ring openingreactions. The resulting intermediate of the ring opening reaction is able to covalen MoreReaction of a nucleobase with nitrosonium ion leads to its diazotization. Due to the instability,the nucleobase-diazonium assumingly falls in dediazotization and successive ring openingreactions. The resulting intermediate of the ring opening reaction is able to covalently cross-linkthe opposite strands of DNA. To examine this assumption for cytosine, some 4-amino-5-cyanopyrimidines were synthesized via [3+3] condensation of amidines with ethoxymethylenemalonitrile and successively converted to the corresponding 4-amino-5carboxyamido derivatives. These compounds were then exposed to nitrosonium ion under different conditions. Results of this study indicate that the diazonium of a 4-aminopyrimidine prefers deamination over the dediazotization. Therefore, the dediazotization and its successive ring-opening reactions of the pyrimidine cation would happen under some exceptionalconditions which deserve to be explored in more detailed studies. In view of the cytosinechemistry and cytotoxicity of NO, the results are presented and discussed. Manuscript profile -
Open Access Article
8 - Green Corrosion Inhibitor for Carbon Steel by Marrubium astranicum Leaves Extracts in 1 M HCl
Banafsheh Norouzi Rahime Hajinasiri Jabber Yousefi Shahram ZabihiThe aim of this study was to investigate the effect of inhibition of Marrubium astranicumleaves extract on the corrosion of carbon steel in hydrochloric acid solution by using weightloss and tafel polarization methods. Inhibition was found to increase with increasingcon MoreThe aim of this study was to investigate the effect of inhibition of Marrubium astranicumleaves extract on the corrosion of carbon steel in hydrochloric acid solution by using weightloss and tafel polarization methods. Inhibition was found to increase with increasingconcentration of the leaves extract. The inhibition efficiency of this extract at an optimumconcentration of 100 mg L-1 was 99.9 %. The effect of inhibitor concentration, immersiontime and temperature on the corrosion behavior of carbon steel in 1 M HCl was also studied.The inhibition was assumed to occur via adsorption of the inhibitor molecules on the metalsurface. The adsorption of the extract on the carbon steel surface obeys the Langmuiradsorption isotherm. The results obtained show that the leave extract of plant could serve asan effective green inhibitor of the corrosion of carbon steel in hydrochloric acid. Manuscript profile
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