Green syntheses of pyrrolooxazole derivatives via multicomponent reaction of alkyl bromides
Subject Areas :
Keywords: Antioxidant activity, Clover leaves, DPPH, Fe3O4 MNPs, FRAP, 1H-Pyrrolooxazole.,
Abstract :
In the present study, iron oxide magneticnanoparticles (Fe3O4 MNPs) were synthesized in a green biosynthetic mannar using aqueous extract of clover leaves. Fe3O4-MNPs were applied as a magnetically separable nanocatalyst for the green syntheses of 1H-pyrrolooxazoles (4a-f) as promising antioxidant compounds in excellent yields at room temperature. The antioxidant activities of the most stable compounds (1a, 1b,4a, and 4b) were evaluated by both DPPH radical scavenging and ferric reduction activity potential (FRAP) assays. Compound 1b was shown a remarkable radical scavenging activity, and 4a was shown very good reducing activity relative to standards (BHT and TBHQ).