Green synthesis of N-methyloxazole derivatives employing bio-Fe3O4-MNPs

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Received: 2025-12-16 Accepted : 2025-12-16 Published : 2025-12-16

Keywords: Fe3O4 MNPs, 1, 3-oxazole, Isothiocyanates, Ammonium thiocyanate, Alkyl (aryl) isothiocyanates.,

Abstract :

1,3-oxazole derivatives were prepared via multicomponent reaction of bromo ketones, aroyl isothiocyanates and methyl iodide in the presence of catalytic amount of Fe3O4 MNPs in water at room temperature in good yields. Also, the reaction of alkyl (aryl) isothiocyanates and -bromo ketones in the presence of catalytic amount of Fe3O4 MNPs in water at room temperature are investigated. The catalyst was reused five times with minor decrease in its catalytic activity. In addition, high yields, easy procedure, easy separation of catalyst from the mixture of reactions are the advantages of these reactions.

References:

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Green synthesis of N-methyloxazole derivatives employing bio-Fe3O4-MNPs