imidazole

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1 - Sepration and determination trace amount of cadmium ions in real and water samples by cloud point extraction - flame atomic absorption spectrophotometry after preconcentration with non-ionic surfactant Triton-X114
gholamhossein vatankhah mahboube ebrahimi darush jafari

2-(3- indolyl) 4,5 di phynyl imidazole.(IDPI) was used as a complexing agent in cloud point extraction for the first time and applied for selective pre-concentration of trace amounts of cadmium. The method is based on the extraction of cadmium at pH= 7.0 by using non-i چکیده کامل

2-(3- indolyl) 4,5 di phynyl imidazole.(IDPI) was used as a complexing agent in cloud point extraction for the first time and applied for selective pre-concentration of trace amounts of cadmium. The method is based on the extraction of cadmium at pH= 7.0 by using non-ionic surfactant Triton-X114 and 2-(3- indolyl) 4,5 di phynyl imidazole. (IDPI) as a chelating agent. The adopted concentrations for IDPI, Triton X-114 and HNO3, bath temperature were optimized, The response are linear over concentration range of 8.0-90 (ng mL-1) for Cd2+ and RSD % (n =5) 1.8 for Cd2+, Detection limits (3SDb/m, n =10, m = slope of calibration) of 2.8 (ng.mL-1) for Cd2+ respectively. The enrichment factors was 33 for Cd2+. the preconcentration factors was 39 for Cd2+ respectively. The high efficiency of cloud point extraction to carry out the determination of analytes in complex matrices was demonstrated. The proposed method was successfully applied to the ultra-trace determination of cadmium in real and water samples. پرونده مقاله

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2 - Determination of Trace Amount of Zn2+ Ion in soil, blood and vegetable and water samples by Flame Atomic Absorption Spectrometry After Cloud Point Extraction Using Selective Synthesis Ligand2-(3- indolyl) – 4,5 di phynyl imidazole.
gholamhossein vatankhah hboube ebrahimi darush jafari

Abstract A simple, sensitive and feasible cloud-point extraction(CPE) methodology has been developed for the separation and preconcentration of cadmium and lead ions in real samples. The metals in the aqueous solution were complexes with 2-(3- indolyl) - 4,5 di phynyl i چکیده کامل

Abstract A simple, sensitive and feasible cloud-point extraction(CPE) methodology has been developed for the separation and preconcentration of cadmium and lead ions in real samples. The metals in the aqueous solution were complexes with 2-(3- indolyl) - 4,5 di phynyl imidazole.(IDPI), at pH = 7.0 and Triton X-114 was added as surfactant. Thevariables effecting like concentration of Triton X-114 and HNO3, bath temperature, centrifuge rate and time on the cloud-point extraction were optimized. Under optimum conditions, the response are linear over concentration range of 0.077-1.29(µg mL-1)for Zn2+andRSD % (n =5) 1.6 forZn2+, Detection limits (3SDb/m, n = 10, m = slope of calibration) of 0.14(µg.mL-1) Zn2+respectively. The enrichment factors was 33, the preconcentrationfactors was 27 for Zn2+respectively. The high efficiency of cloud point extraction to carry out the determination of analytes in complex matrices was demonstrated. The proposed method was successfully applied to the ultra-trace determination of cadmium in real samples. پرونده مقاله

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3 - Quantitative structure–property relationship models to Predict some thermodynamic properties of Imidazole Derivatives using molecular descriptor and genetic algorithm-multiple linear regressions
shiva Moshayedi fatemeh shafiei Tahereh Momeni Isfahani

10.30495/jptc.2021.20401

Imidazole is compound with a wide range of biological activities and imidazole derivatives are the basis of several groups of drugs.In this study the relationship between molecular descriptors and the thermal energy (Eth kJ/mol), and heat capacity (Cv J/mol) of imidazol چکیده کامل

Imidazole is compound with a wide range of biological activities and imidazole derivatives are the basis of several groups of drugs.In this study the relationship between molecular descriptors and the thermal energy (Eth kJ/mol), and heat capacity (Cv J/mol) of imidazole derivatives is studied. The chemical structures of 85 Imidazole derivatives were optimized at HF/6-311G* level with Gaussian 98 software.Molecular descriptors were calculated for selected compound by using the Dragon software.The Genetic algorithm- multiple linear regression (GA-MLR) and backward methods were used to select the suitable descriptors and also for predicting the thermodynamic properties of imidazole derivatives.The obtained models were evaluated by statistical parameters, such as correlation coefficient (R2adj), Fisher ratio (F), Root Mean Square Error (RMSE), Durbin-Watson statistic (D) and significance (Sig).The predictive powers of the GA- MLR models are studied using leave-one-out (LOO) cross-validation and external test set. The predictive ability of the GA-MLR models with two-three selected molecular descriptors was found to be satisfactory. The developed QSPR models can be used to predict the property of compounds not yet synthesized. پرونده مقاله

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4 - Application of Water for Synthesis of Cyclopentadienes via Multi-component Reactions of N-methyl imidazole
Alireza Ahmadi Agh Mashhadi Zinatossadat Hossaini

A water-accelerated multi-component synthesis of organic target molecules was used as a key method for the preparation of cyclopentadiene derivatives. The three-component condensation reactions of primary amines with alkyl propiolates in the presence of N-methylimidazol چکیده کامل

A water-accelerated multi-component synthesis of organic target molecules was used as a key method for the preparation of cyclopentadiene derivatives. The three-component condensation reactions of primary amines with alkyl propiolates in the presence of N-methylimidazole in water at room temperature were developed as efficient and clean green synthetic procedures for the high-yielding preparation of 4-oxo-2,5-cyclopentadiene-1,2-dicarboxylate derivatives. پرونده مقاله

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5 - Three Component Syntheses of Pyrrolo Imidazole Derivatives in the Presence of N-methyl imidazole, Activated Acetylenes and Phenylsulfonylacetophenone
Anvar Mirzaei

Because of the significant role in biological processes in living cells and the diverse types of physiological activities, heterocyclic compounds are in focus of intense investigations by academic, industry and applied-oriented chemists. Considerably, ascientific rena چکیده کامل

Because of the significant role in biological processes in living cells and the diverse types of physiological activities, heterocyclic compounds are in focus of intense investigations by academic, industry and applied-oriented chemists. Considerably, ascientific renaissance of heterocycles during the last decades is closely related to the development of multicomponent approaches to their synthesis. Multicomponent methodology is fundamentally different from two-component or sequential processestogether with other innovative synthetic methods like microwave- and ultrasonic assisted reactions offer some new possibilities in constructing heterocyclic systems with high level of molecular diversity and complexity. Among them Imidazoles are quite important reagents in modern heterocyclic chemistry, and their reactions with electrophiles are the most widespread and facile synthetic approach for obtaining diverse heterocyclic systems containing Imidazolemoiety. An interest on these heterocycles is attributed to their known biological activities: analgesics, cardiovascular vasodilators, calcium channel blocking agents, potassium channel inhibitors, apoptosis-inducers, and so on. In this research, N-methyl imidazole reacts smoothly with dialkylacetylenedicarboxylates in the presence of phenylsulfonyl acetone to produce pyrroloimidazole derivatives in good yields. پرونده مقاله

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6 - Swelling Characterization of Nanocomposite Hydrogels of Poly (acrylamide-N-vinylimidazole)
Zhila Shirzadeh Shahrbano Foladi Kh. Didehban

In this study, a hydrogel composed of acrylamide (AAm) with N-vinylimidazole (NVI) as co-monomer, with a cross-linker such as N, N` Methylenebisacrylamide and potassium peroxodisulfate as an initiator solution was prepared. Poly (AAm/NVI) hydrogels were synthesized b چکیده کامل

In this study, a hydrogel composed of acrylamide (AAm) with N-vinylimidazole (NVI) as co-monomer, with a cross-linker such as N, N` Methylenebisacrylamide and potassium peroxodisulfate as an initiator solution was prepared. Poly (AAm/NVI) hydrogels were synthesized by free radical solution polymerization. Swelling experiments were performed in water at 25°C, gravimetrically. Here, it was of interest to increase the water absorption capacity of AAm hydrogels with add VI. AAm is a highly hydrophilic monomer, and VI monomer is neutral. The one purpose of this study is to combine both monomers in one polymer. In this respect, a series of hydrogels was synthesized by changing the content of AAm and VI. Then, some swelling of these hydrogels was studied in water. پرونده مقاله

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7 - Caro’sacid-silicagel: An Efficient and Reusable Catalyst for the Synthesis of 2, 4, 5- Trisubstituted Imidazoles under Solvent-free Conditions
Khalil Pourshamsian Naser Montazeri Sadegh Asadyan

Caro’s acid-silicagel was found to be a mild and effective catalyst for the one –pot multicomponent condensation of benzyl, aldehydes and ammonium acetate used for synthesis of 2, 4, 5-trisubstituted imidazole derivatives under solvent–free conditions. چکیده کامل

Caro’s acid-silicagel was found to be a mild and effective catalyst for the one –pot multicomponent condensation of benzyl, aldehydes and ammonium acetate used for synthesis of 2, 4, 5-trisubstituted imidazole derivatives under solvent–free conditions. This catalyst has several advantages such as simple work-up, low cost and reusability. پرونده مقاله

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8 - Application of N-methylimidazole for the Synthesis of Dimethyl-{3-methyl-2-[(alkoxycarbonyl) anilino]-2,3-dihydro-1H-imidazol-1-yl)}-2-butenedioate Derivatives
Rahimeh Hajinasiri Halimeh Khatoon Khajavi

A one-pot synthesis ofdimethyl-{3-methyl-2-[(alkoxycarbonyl) anilino]-2,3-dihydro-1Himidazol-1-yl)}-2-butenedioatesanddimethyl-2-[(alkoxycarbonyl)anilino]-2-butenedioates derivatives via reactions between dimethyl acetylenedicarboxylate,1-methylimidazoleand N-phenylcarb چکیده کامل

A one-pot synthesis ofdimethyl-{3-methyl-2-[(alkoxycarbonyl) anilino]-2,3-dihydro-1Himidazol-1-yl)}-2-butenedioatesanddimethyl-2-[(alkoxycarbonyl)anilino]-2-butenedioates derivatives via reactions between dimethyl acetylenedicarboxylate,1-methylimidazoleand N-phenylcarbamates is described. The mild reaction condition, simple mixing of the starting materials and good yields exhibit the synthetic advantage of this method. پرونده مقاله

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9 - New Pt(II) Complexes with Heterocyclic Ligands Derived from Benzimidazole: Synthesis, Characterization, DFT Calculations and Catalytic Activities
Parisa Sadeghzadeh Mehdi Pordel Safar Ali Beyramabadi Abolghasem Davoodnia

In this work, the synthesis, spectral characterization, DFT calculations, and catalytic activity of thenew Pt(II) complexes with the ligand derived from benzimidazole derivatives have been described.The new heterocyclic ligands were obtained from the reaction of o-amino چکیده کامل

In this work, the synthesis, spectral characterization, DFT calculations, and catalytic activity of thenew Pt(II) complexes with the ligand derived from benzimidazole derivatives have been described.The new heterocyclic ligands were obtained from the reaction of o-amino-ketones with hydrazinehydrate in high yieldandPt(II) complexes prepared from the coordination of the new ligands toPt(II) cation. The new compounds have been characterized by spectral and microanalytical data.The DFT calculations at the B3LYP/6-311+G(d,p) level were also applied to gain further insightinto the geometry of Pt(II) complexes. The catalytic activity of Pt(II) complexes in Biginellireactionwas also examined as heterogeneous catalysts. The results showed that the 3,4-dihydropyrimidin-2(1H)-ones have been synthesized, in excellent yields, under solvent-free conditions, by reaction oftert-butyl acetoacetate, alcohol, arylaldehydes, and urea in the presence of Pt(II) complexes as anefficient and heterogeneous and catalyst. پرونده مقاله

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10 - New Benzimidazoles Derivatives: Synthesis, Characterization and Antifungal Activities
Abbas Ahmadi Babak Nahri-Niknafs

One of the most important goals in medicinal chemistry is the development of new heterocyclic compounds with pharmaceutical activity. Thus, a novel series of the derivatives of benzimidazole were synthesized and the structures of all the synthesized compounds have been چکیده کامل

One of the most important goals in medicinal chemistry is the development of new heterocyclic compounds with pharmaceutical activity. Thus, a novel series of the derivatives of benzimidazole were synthesized and the structures of all the synthesized compounds have been confirmed by IR, 1 H- and 13C-NMR, Mass Spectroscopy and elemental analysis. The title compounds have been evaluated for antifungal activities against Candida albicans, Candida glabrata, and Candida krusei. Some of these compounds have been found to exhibit moderate to good antifungal activity when compared with commercially available fungicides. پرونده مقاله

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11 - Co(II) تثبیت شده بر روی بستر مغناطیسی نانوفیبر سلولز آمین دار شده: یک نانوکاتالیزگر مغناطیسی ناهمگن جدید، زیستی و کارآمد برای سنتز مشتقات بنزایمیدازول
مهری سلیمی معصومه جعفرپور سوسن یزدانی شواکند فهیمه فیض پور

کبالت تثبیت شده بر روی نانوفیبر سلولز مغناطیسی عامل دار شده با آمین(Fe3O4@CNF-NH2- CoII) به عنوان یک نانوکاتالیزگر جدید مبتنی بر بستر زیستی سنتز شد. کاتالیزگر سنتز شده با طیف‌سنجی مادون قرمز-تبدیل فوریه(FT-IR)، میکروسکوپ الکترونی روبشی(SEM)، طیف‌سنجی پراش انرژی پرتو ایک چکیده کامل

کبالت تثبیت شده بر روی نانوفیبر سلولز مغناطیسی عامل دار شده با آمین(Fe3O4@CNF-NH2- CoII) به عنوان یک نانوکاتالیزگر جدید مبتنی بر بستر زیستی سنتز شد. کاتالیزگر سنتز شده با طیف‌سنجی مادون قرمز-تبدیل فوریه(FT-IR)، میکروسکوپ الکترونی روبشی(SEM)، طیف‌سنجی پراش انرژی پرتو ایکس(EDX)، میکروسکوپ الکترونی عبوری(TEM)، آنالیز وزن سنجی حرارتی(TGA)، مغناطیس‌سنجی نمونه ارتعاشی(VSM) و طیف سنجی نشر اتمی پلاسمای جفت شده القایی(ICP-OES) مشخصه یابی و مورفولوژی آن مورد بررسی قرار گرفت. این نانو کاتالیزگر مغناطیسی برای سنتز کارآمد مشتقات بنزایمیدازول از طریق واکنش تراکمی آلدهید های آروماتیک و آریل 2،1-دی آمین ها با استفاده از اتانول به عنوان حلال تحت اتمسفر هوا به خوبی عمل کرد. نانوکاتالیزگر فوق، به طور موفقیت آمیز توسط آهنربای خارجی تا 5 بار مورد بازیافت و بدون کاهش چشمگیر در فعالیت آن مورد استفاده مجدد قرار گرفت. استفاده ازحلال سبز در سنتز بنزایمیدازول ها، راندمان خوب تا عالی محصولات، استفاده ازکاتالیزگر قابل بازیافت بدون از دست دادن فعالیت کاتالیزگری، روش کارساده، این روش را ازنظر محیط زیستی و اقتصادی برای سنتزبنزایمیدازول ها مطلوب می کند. پرونده مقاله

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12 - ارتباط کمی ساختار-فعالیت بر روی یک سری از مشتقات ایمیدازو [1 و 2-a ] پیریدین کربوکسامید به عنوان عوامل ضد سل
محسن نکوئی نیا سعید یوسفی نژاد

مقاومت بیماری سل به دارو همچنان یکی از مهمترین چالش های پیش رو در درمان این بیماری عفونی است و بنابراین کشف و توسعه داروهای جدید موثر ضد سل همواره مورد توجه محققان است. در این مطالعه، تحلیل ارتباط کمی ساختار-فعالیت (QSAR) بر روی یک سری از مشتقات ایمیدازول[1 و2- a] پیرید چکیده کامل

مقاومت بیماری سل به دارو همچنان یکی از مهمترین چالش های پیش رو در درمان این بیماری عفونی است و بنابراین کشف و توسعه داروهای جدید موثر ضد سل همواره مورد توجه محققان است. در این مطالعه، تحلیل ارتباط کمی ساختار-فعالیت (QSAR) بر روی یک سری از مشتقات ایمیدازول[1 و2- a] پیریدین کربوکسامید به عنوان عوامل ضد سل اعمال شد. فعالیت بیولوژیکی 18 ترکیب با روش های رگرسیون خطی چندگانه و شبکه عصبی مصنوعی برآورد شد. چهار توصیف کننده مولکولی (nCl، MATS8m، BELe4 وGATS8e) با استفاده از رگرسیون خطی چندگانه گام به گام انتخاب شدند. بهترین نتایج شبکه عصبی مصنوعی با الگوی 5-5-1 آموزش داده شده با الگوریتم پس انتشار رو به جلو به دست آمد. یک مجموعه آزمون حاوی 5 ترکیب برای ارزیابی توانایی پیش‌بینی مدل استفاده شد. نتایج نشان داد که رویکرد شبکه عصبی مصنوعی در مقایسه با رگرسیون خطی چندگانه قدرت پیش بینی بهتری را ارائه می دهد. بر اساس نتایج این مطالعه، الکترونگاتیوی، جرم اتمی و هندسه مولکولی عوامل مهم کنترل کننده فعالیت ضد سل هستند. پرونده مقاله

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13 - سنتز کارآمد بنزیمیدازول ها در شرایط بدون حلال با استفاده از کمپلکس کیتوسان-مس (II) استخراج شده از پوسته میگوی خلیج فارس
یوسف دلشاد عبدالحمید دهقانی میلاد قزلسفلو سهیلا قاسمی

در این پژوهش، کاتالیزگری ارزان قیمت، دوست دار محیط زیست و قابل استفاده مجدد با روش مناسب سنتز شده است. برای این منظور، ابتدا ذرات کیتوسان از طریق فرایند استیل زدایی از ضایعات پوسته میگوی خلیج فارس تهیه شده و در ادامه کمپلکسی مبتنی بر مس بر روی بستری از ذرات کیتوسان با م چکیده کامل

در این پژوهش، کاتالیزگری ارزان قیمت، دوست دار محیط زیست و قابل استفاده مجدد با روش مناسب سنتز شده است. برای این منظور، ابتدا ذرات کیتوسان از طریق فرایند استیل زدایی از ضایعات پوسته میگوی خلیج فارس تهیه شده و در ادامه کمپلکسی مبتنی بر مس بر روی بستری از ذرات کیتوسان با موفقیت بدست آمد. ساختار کمپلکس کیتوسان-مس(II)، با استفاده از روش های گوناگون از قبیل طیف سنجی مادون قرمز تبدیل فوریه، پراش پرتو ایکس، میکروسکوپ الکترونی روبشی، طیف سنجی پراش انرژی پرتو ایکس و طیف سنجی مرئی- فرابنفش تایید شد. با توجه به کاربرد وسیع بنزیمیدازول ها در صنعت و داروسازی، خواص کاتالیزگری کمپلکس کیتوسان-مس (II)سنتز شده، در واکنش دو جزئی سنتز مشتق های مختلف بنزیمیدازول تحت شرایط بدون حلال مطالعه شد. استفاده از کاتالیزگر کمپلکس کیتوسان-مس(II)، در سنتز مشتقات بنزیمدازول چندین مزیت از جمله بازده قابل توجه، شرایط واکنش ملایم، زمان سنتز کوتاه، جداسازی آسان کاتالیزگر و اجتناب از تولید زباله های سمی را نشان داد. علاوه بر این، کمپلکس کیتوسان-مس(II) به راحتی توسط صاف کردن بازیابی شد و می‌توان آن را برای پنج چرخه بدون از دست دادن فعالیت کاتالیزگری مورد استفاده ی مجدد قرار داد. پرونده مقاله

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14 - Synthesis Mechanism of formation and Advanced applications of some unique five membered heterocycle derivatives
Noor ud Din Zargar Khaliq uz Zaman Khan

ABSTRACTHeterocyclic compounds are widely distributed in nature and have played a vital role in synthetic organic chemistry. Five membered heterocycles, an important class of heterocyclic compounds, have been frequently synthesized and find a diverse range of applicatio چکیده کامل

ABSTRACTHeterocyclic compounds are widely distributed in nature and have played a vital role in synthetic organic chemistry. Five membered heterocycles, an important class of heterocyclic compounds, have been frequently synthesized and find a diverse range of applications in chemistry, biology and biochemistry of both pharmacological and chemical importance. Palladium-catalyzed cyclisation of different enynethiols has afforded a series of substituted thiophenes. The substrates, (Z)-2-en-4-yne-1- thiols, undergo cyclo isomerisation in dimethyl acetamide in the presence of catalytic amounts of PdI2 along with KI, to yield corresponding thiophenes 4 . Chiral imidazoles have been synthesized by thio-Ugi reaction . The method involves the treatment of thioamides with ammonia and cyclisation of the resulting substituted amidines in aqueous hydrochloric acid to afford corresponding imidazoles 11.This article will discuss on various synthetic pathways adopted for the synthesis of different five membered heterocycle derivatives and explore the mechanistic aspects apart from the recent applications of some unique compounds. پرونده مقاله

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15 - One pot three-component synthesis of imidazole derivatives using NH3/NH4Cl
Amineh Derisavi Mohammad Kazem Mohammadi

Imidazole is a planar, five membered heteroaromatic molecule with pyrrole type and pyridine type annular nitrogens. Several approaches are available of imidazoles from alpha halo ketones, aminonitrile, aldehyde ect. Reactivity of imidazole and benzimidazole is referred چکیده کامل

Imidazole is a planar, five membered heteroaromatic molecule with pyrrole type and pyridine type annular nitrogens. Several approaches are available of imidazoles from alpha halo ketones, aminonitrile, aldehyde ect. Reactivity of imidazole and benzimidazole is referred from sets of resonance structure in which the dipolar contributors have finite importance. Imidazoles among the principal groups of heterocyclic compounds that have biological properties. Due to the presence of imidazole rings in natural products and active pharmaceutical ingredients, different ways for the synthesis of heterocyclic compounds of this type investigated. The aim of this project is substituted derivatives 2,4,5-Imidazoles. In this study, three-substituted imidazole compounds synthesized using ammonium chloride as a catalyst cost in terms of reflux were studied. Reaction with aldehydes and ammonium acetate Acenaphthene quinone in crowding conditions in the presence of ammonium chloride was performed successfully and imidazole derivatives were prepared with good yields. The key advantages of this process are high yields,cost effectiveness of catalyst,easy work-up and purification of products by non-chromatographic method. پرونده مقاله

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16 - Synthesis of new trisubtitued imdidazole compounds in solvent free condition
Omid Baravaye

Treatment of 7-chloro-1-phenylpyrimido[4,5-e][1,3,4]thiadiazines with hydrazine in boiling ethanol gave corresponding7-hydrazinyl derivatives. Diazotization of the latter compounds acheived a mixture of 5H-tetrazolo[1',5':1,2]pyrimido[4,5-e][1,3,4]thiadiazine and 9H-tet چکیده کامل

Treatment of 7-chloro-1-phenylpyrimido[4,5-e][1,3,4]thiadiazines with hydrazine in boiling ethanol gave corresponding7-hydrazinyl derivatives. Diazotization of the latter compounds acheived a mixture of 5H-tetrazolo[1',5':1,2]pyrimido[4,5-e][1,3,4]thiadiazine and 9H-tetrazolo[5',1':2,3]pyrimido[4,5-e][1,3,4]thiadiazines. Ratio of these two group of products determined by 1HNMR studies and no significant preference was observed for their formation. Efforts for separation of the products were unsuccessful and its reason is discussed. پرونده مقاله

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17 - Synthesis of new phenanthro imidazole derivatives in solvent free condition
Masih Golkari

phenanthro Imidazole derivatives were made synthesis the combinations of phenanthroquinone , Benzealdehyde derivatives in the presence of amines compounds. In all reactions, reactions were investigated under Microwave conditions. The structure of all compounds was studi چکیده کامل

phenanthro Imidazole derivatives were made synthesis the combinations of phenanthroquinone , Benzealdehyde derivatives in the presence of amines compounds. In all reactions, reactions were investigated under Microwave conditions. The structure of all compounds was studied by an IR Spectrums and 1HNMR Spectrums. Excellent yields, short reaction times, simplicity of operation and easy separation are several advantages of this technique. The results shown that the optimal conditions for the formation of phenanthro derivative of imidazole are at 70 ˚C, the power of 400 W and the time of two minutes. پرونده مقاله

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18 - Baker’s yeast promoted green synthesis of functionalized imidazoles using multicomponent reaction of guanidine
Neda Mashal Javad Azizian Kambiz larijani Fereshteh Nematollahi Homa Azizian

10.30495/iranjoc.2023.704987

In this research new derivatives of imidazoles were prepared using multicomponent reactions of primary amines, isocyanates, diethyl oxalate and guanidine in water at room temperature in the presence of baker’s yeast as catalyst in good yields. The short time of re چکیده کامل

In this research new derivatives of imidazoles were prepared using multicomponent reactions of primary amines, isocyanates, diethyl oxalate and guanidine in water at room temperature in the presence of baker’s yeast as catalyst in good yields. The short time of reaction, high yields of product and easy separation of them are some advantages of this procedure. Another work in this research is investigation of antioxidant property of some synthesized compounds by diphenyl-picrylhydrazine (DPPH) radical trapping experiment. Presently, bacteria that are not destroyed with drug have generated many problems in the performance of much transferable disease. For this reason, discovering appropriate and new procedures for the dealing with these pathogens are important and recent study has focused on the investigation of the antibacterial effects on the prepared compounds. پرونده مقاله

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19 - Efficient synthesis of imidazole derivatives using multicomponent reactions of activated acetylenic compounds
Narges Ghasemi Parvaneh Firoozi-Khanghah Narjes Haerizadeh

10.30495/iranjoc.2023.706235

An efficient synthesis of imidazolo thiazines is described. This involves a reaction of isothiocyanate with Pyruvates in the Presence of imidazole.

An efficient synthesis of imidazolo thiazines is described. This involves a reaction of isothiocyanate with Pyruvates in the Presence of imidazole. پرونده مقاله

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20 - An efficient synthesis of new derivatives of thiazole using multicomponent reactions
Mahboubeh Ghasemian Dazmiri Loghman Moradi

10.30495/iranjoc.2023.706238

N-methyl imidazole accelerated synthesis of thiazole derivatives by employing of three-component reactions of primary amines, dialkyl acetylenedicarboxylates and isothiocyanates under solvent-free conditions at room temperature in a good yield. The above synthetic proce چکیده کامل

N-methyl imidazole accelerated synthesis of thiazole derivatives by employing of three-component reactions of primary amines, dialkyl acetylenedicarboxylates and isothiocyanates under solvent-free conditions at room temperature in a good yield. The above synthetic procedure offers rapid access to novel and diversely substituted thiazole derivatives. پرونده مقاله

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21 - Snail shell as a natural and highly efficient catalyst for the synthesis of imidazole derivatives
Zakaria Benzekribe Houda Serrar Abdelkebir Zarguil Said Boukhris Abdelaziz Souizi

A convenient, simple and green process for the synthesis of 2,4,5-triaryl-1H-imidazole and 1,2,4,5-tetraaryl-1H-imidazole derivatives using snail shell, which is abundant in Morocco, as a catalyst in ethanol at 40 °C has been developed. Additionally, short reaction چکیده کامل

A convenient, simple and green process for the synthesis of 2,4,5-triaryl-1H-imidazole and 1,2,4,5-tetraaryl-1H-imidazole derivatives using snail shell, which is abundant in Morocco, as a catalyst in ethanol at 40 °C has been developed. Additionally, short reaction times, excellent yields, simple procedure and relative non-toxicity of the catalyst are other noteworthy advantages and make this method an interesting alternative to other methodologies. Finally, this solid catalyst can be recovered and reused at least seven times with negligible loss in activity. The catalyst has been characterized by X-ray diffraction, scanning electron microscope, Fourier transforms infrared spectroscopy (FT-IR) and measuring the specific surface. پرونده مقاله

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22 - One-pot synthesis of tri- and tetrasubstituted imidazoles using nano-LaMnO3 perovskite-type oxide as reusable heterogeneous catalyst in solvent-free condition
Haleh Sanaeishoar Haman Tavakkoli Mahsa Asareh Fouad Mohave

A convenient synthetic method for the synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetra substituted imidazole derivatives, has been developed via one-pot condensation reaction in solvent-free condition when aldehyde, ammonium acetate/amine, and 1,2-diketone are reacte چکیده کامل

A convenient synthetic method for the synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetra substituted imidazole derivatives, has been developed via one-pot condensation reaction in solvent-free condition when aldehyde, ammonium acetate/amine, and 1,2-diketone are reacted using 0.8 mol% of NP-LaMnO3 at 80 °C under solvent free conditions. Catalyst could be recovered and reused in five reaction cycles without any loss of its activities, giving a total turnover number (TON) = 594 and turn over frequency (TOF) = 71 h−1. High yield, little catalyst loading, elimination of solvent, simple workup, recovery and reusability of the catalyst are some of the impressive features of the present method. پرونده مقاله

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23 - 5-sulfosalicylic acid as an efficient organocatalyst for environmentally benign synthesis of 2-substituted benzimidazoles
Chandrakant Bhenki Shrikrishna Karhale Vasant Helavi

A water soluble, Bronsted acid, 5-sulfosalicylic acid as an efficient organocatalyst was used for the synthesis of physiologically active 2-substituted benzimidazole derivatives from o-phenylenediamine and aromatic aldehydes in ethanol at reflux condition. Cost-effectiv چکیده کامل

A water soluble, Bronsted acid, 5-sulfosalicylic acid as an efficient organocatalyst was used for the synthesis of physiologically active 2-substituted benzimidazole derivatives from o-phenylenediamine and aromatic aldehydes in ethanol at reflux condition. Cost-effectiveness, use of non-hazardous solvents, metal free and commercially available catalyst, single-step, environmentally friendly green method, high conversions, cleaner reaction profiles and simple experimental and workup procedures are the remarkable features of this method. A water soluble, Bronsted acid, 5-sulfosalicylic acid as an efficient organocatalyst has been used for the synthesis of physiologically active 2-substituted benzimidazole derivatives from o-phenylenediamine and aromatic aldehydes in ethanol at reflux condition. Cost-effectiveness, use of non-hazardous solvents, metal free and commercially available catalyst, single step, environmentally friendly green method, high conversions, cleaner reaction profiles and simple experimental and workup procedures are the remarkable features of this method. پرونده مقاله

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24 - Kaolin-SO3H as an efficient catalyst for one-pot synthesis of 1,2,4,5-tetrasubstituted imidazoles
Bi Bi Fatemeh Mirjalili Hamidreza Akrami

Kaolin-SO3H as a new solid acid is prepared via reaction of kaolin and chlorosulfonic acid. This natural based catalyst is very inexpensive and easy available. Imidazoles are an important class of heterocycles being the core fragment of different natural products and bi چکیده کامل

Kaolin-SO3H as a new solid acid is prepared via reaction of kaolin and chlorosulfonic acid. This natural based catalyst is very inexpensive and easy available. Imidazoles are an important class of heterocycles being the core fragment of different natural products and biological systems such as anti-allergic, anti-inflammatory, analgesic, antifungal, antimycotic, antibiotic, antiulcerative, antibacterial, antitumor and inhibitors of the p38 MAP kinase. A simple, highly versatile and efficient synthesis of 1,2,4,5-tetrasubstituted imidazoles is achieved using Kaolin-SO3H as a catalyst at moderate temperature under solvent free condition. The key advantages of this process are high yields with simple work-up using easy available inexpensive natural based catalyst. پرونده مقاله

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25 - Nano TiO2@SiO2 as an efficient and reusable catalyst for the synthesis of multi-substituted imidazoles
Maryam Haghighi Kobra Nikoofar

Nano TiO2 supported on SiO2 (Nano TiO2@SiO2) as a solid Lewis acid, was described to be an effective and reusable catalyst for one-pot three-component reaction of benzil, aryl aldehydes and ammonium acetate for the synthesis 2-aryl-4,5-diphenyl-1H-imdazoles synthesis. T چکیده کامل

Nano TiO2 supported on SiO2 (Nano TiO2@SiO2) as a solid Lewis acid, was described to be an effective and reusable catalyst for one-pot three-component reaction of benzil, aryl aldehydes and ammonium acetate for the synthesis 2-aryl-4,5-diphenyl-1H-imdazoles synthesis. To explore the high efficacy of the catalytic system the four-component cyclization of benzil, aryl aldehydes, ammonium acetate and anilines has also been accomplished successfully to obtain their 1,2-diaryl-4,5-diphenyl-1H-imidazole adducts. A plausible mechanism has also been expressed. The catalyst has been recovered and its reusability confirmed in 4 runs. High yields, simple operation, easy-work procedure, mild reaction conditions in addition with reusability are some advantages of this protocol. پرونده مقاله

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26 - Synthesis of benzimidazole derivatives using Ni2+ supported on hydroxyapatite-core@shell γ-Fe2O3 nanoparticles both under solvent and solvent-free conditions
Eshagh Rezaee Nezhad Saaid Karimian

Ni2+ supported on hydroxyapatite-core@shell γ-Fe2O3 nanoparticles (γ-Fe2O3@HAp-Ni2+) was found to be a useful catalyst for the synthesis of benzimidazole derivatives from o-phenylenediamine and aldehydes under solvent and solvent-free conditions at 80 °C چکیده کامل

Ni2+ supported on hydroxyapatite-core@shell γ-Fe2O3 nanoparticles (γ-Fe2O3@HAp-Ni2+) was found to be a useful catalyst for the synthesis of benzimidazole derivatives from o-phenylenediamine and aldehydes under solvent and solvent-free conditions at 80 °C. This reaction affords the corresponding benzimidazole derivatives compared with the classical reactions this method consistently gives a high yield, easy magnetic separation, a short reaction time, simple workup and recyclable property of the catalyst. In this way, the catalyst was readily recovered using an external magnet and could be reused in five consecutive runs without significant loss of reactivity. The mean size and the surface morphology of the nanocatalyst were characterized by TEM, SEM, VSM, XRD and FTIR techniques. پرونده مقاله

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27 - Synthesis of 2,4,5-triaryl-1H-imidazoles using a potent, green and reusable nano catalyst (FHS/SiO2)
Mehdi Bakavoli Hossein Eshghi Ali Mohammadi Hassanali Moradi Javad Ebrahimi

A simple, green and efficient method for synthesis of 2,4,5-trisubstituted imidazoles is described via three-component cyclocondensation of benzil or benzoin, aldehyde and ammonium acetate by using the nano SiO2-supported ferric hydrogen sulfate (FHS/SiO2), as a catalys چکیده کامل

A simple, green and efficient method for synthesis of 2,4,5-trisubstituted imidazoles is described via three-component cyclocondensation of benzil or benzoin, aldehyde and ammonium acetate by using the nano SiO2-supported ferric hydrogen sulfate (FHS/SiO2), as a catalyst, under solvent-free conditions. The nano SiO2 support and catalyst were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM) and IR spectroscopy. In this project, the optimum conditions such as: reaction temperature, reaction time and amount of catalyst were investigated. The major advantages of the present method are high yields, shorter reaction times, easy work-up, purification of products by non-chromatographic method and the reusability of the catalyst. پرونده مقاله

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28 - Spotlight: Use of heterogeneous catalysts in benzimidazole synthesis
Elham Amouhadi

Elham Amouhadi was born in 1983 in Esfahan, Iran. She received her B.Sc. in Applied Chemistry (2005) and M.Sc. in Inorganic Chemistry (2016) from Islamic Azad University Shahreza Branch. She is currently working towards her Ph.D. under the supervision of Professor Razie چکیده کامل

Elham Amouhadi was born in 1983 in Esfahan, Iran. She received her B.Sc. in Applied Chemistry (2005) and M.Sc. in Inorganic Chemistry (2016) from Islamic Azad University Shahreza Branch. She is currently working towards her Ph.D. under the supervision of Professor Razieh Fazaeli at Islamic Azad University Shahreza Branch. Her research interest is the design, synthesis, and characterization of Inorganic Catalysts. پرونده مقاله

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29 - Trifluoroacetate-bonded polyethylene graphene oxide composite as a novel and efficient catalyst for the synthesis of benzimidazoles under solvent-free conditions
Esmael Rostami Seyed Mahdi Haghayeghi

A green and efficient trifluoroacetate-bonded polyethylene graphene oxide composite was utilized in this research to prepare benzimidazoles with good to excellent yield under a solvent-free condition. The trifluoroacetate-bonded polyethylene graphene oxide composite was چکیده کامل

A green and efficient trifluoroacetate-bonded polyethylene graphene oxide composite was utilized in this research to prepare benzimidazoles with good to excellent yield under a solvent-free condition. The trifluoroacetate-bonded polyethylene graphene oxide composite was constructed by polyethylene/diethylenetriamine-functionalized graphene oxide composite bonded by 2-aminothiazole and CF3COOHmoieties. Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD) analysis, field emission scanning electron microscopy (FESEM), energy dispersive x-ray spectroscopy (EDS), and thermogravimetric analysis (TGA) were also employed to characterize the composite. Benzimidazoles were synthesized by reacting 1,2-phenylenediamine with aromatic aldehydes in the presence of composite (0.02 g) under solvent-free conditions at 75°C. The composite was recovered and used in five runs without considerable loss of activity. Compared to the other catalysts employed for the synthesis of benzimidazole, the present composite (catalyst) benefits from a series of advantages such as cost-effectiveness, easy storage and handling, recoverability and durability, environmental friendliness, non-metallic nature, and ease of disposal. The present synthetic route has also some advantages, including, moderate condition, easy workup, solvent-free nature, and environmental safety. پرونده مقاله

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30 - Synthesis of 5-amino-1-aryl-4-cyanoimidazoles from formamidines under solvent-free condition
Asieh Yahyazadeh Farhad Shirini Fatamah Tavakoli

The aryl-(Z)-N-[2-amino-1,2-dicyanovinyl]formamidine 2 cyclize in solvent-free conditions and in the presence of a base to give a 5-amino-1-aryl-4-cyanoimidazoles 3. Silica sulfuric acid as an efficient and reusable heterogeneous catalyst has been used for the preparati چکیده کامل

The aryl-(Z)-N-[2-amino-1,2-dicyanovinyl]formamidine 2 cyclize in solvent-free conditions and in the presence of a base to give a 5-amino-1-aryl-4-cyanoimidazoles 3. Silica sulfuric acid as an efficient and reusable heterogeneous catalyst has been used for the preparation of amidines 2 from formimidate 1 through reaction with aromatic amines at room temperature and in good to excellent yields. All these derivatives were fully characterized by spectroscopic data. پرونده مقاله

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31 - Trans-3,5-dihydroperoxy-3,5-dimethyl-1,2-dioxolane/HOAc/KI system as a new and mild catalyst for efficient synthesis of 1H-benzimidazoles and 1H-benzothiazoles in water
Kaveh Khosravi Akbar Mobinikhaledi Samira Kazemi Davood Azarifar Payam Rahmani

An efficient method has been developed for the catalysis of condensation of 1,2-phenylenediamines and 2-aminothiophenoles with different aldehydes into their corresponding 2-aryl-1H-benzimidazoles and 2-aryl-1H-benzothiazoles under mild condition. In this method, trans- چکیده کامل

An efficient method has been developed for the catalysis of condensation of 1,2-phenylenediamines and 2-aminothiophenoles with different aldehydes into their corresponding 2-aryl-1H-benzimidazoles and 2-aryl-1H-benzothiazoles under mild condition. In this method, trans-3,5-dihydroperoxy-3,5-dimethyl-1,2-dioxolane (DHPDMDO)/HOAc/KI system was used as a novel and effective oxidant in water at room temperature with excellent results. پرونده مقاله

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32 - Synthesis of 2-Substitued Benzimidazoles Using P2O5-SiO2
Ahmad Reza Momeni Somayeh Bagheri

P2O5-SiO2 (30% w/w) was found to be a useful catalyst for the synthesis of various 2-substituted aryl benzimidazoles under solvent-less and in solvent conditions from o-phenylenediamine and aldehydes. The products were directly recrystallized from methanol.

P2O5-SiO2 (30% w/w) was found to be a useful catalyst for the synthesis of various 2-substituted aryl benzimidazoles under solvent-less and in solvent conditions from o-phenylenediamine and aldehydes. The products were directly recrystallized from methanol. پرونده مقاله

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33 - Improving methodology for the preparation of highly substituted imidazoles using nano-MgAl2O4 as catalyst under microwave irradiation
Javad Safari Soheila Gandomi-Ravandi Zahra Akbari

An efficient synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles by one-step condensation of an aldehyde, benzil, ammonium acetate and primary amine in the presence of nanocrystalline magnesium aluminate under microwave irradiation is described. Th چکیده کامل

An efficient synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles by one-step condensation of an aldehyde, benzil, ammonium acetate and primary amine in the presence of nanocrystalline magnesium aluminate under microwave irradiation is described. The advantages of this catalyst are including simple work-up, low cost and reusability. Compared with conventional methods, the main advantages of the present procedure are its being a green method, its milder conditions, necessary shorter reaction time, and its higher yields and its selectivity. The structures of products were characterized by 1H NMR, 13C NMR, IR, elemental analyses, MS and UV spectral data. Their melting points were compared with literature report. پرونده مقاله

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34 - Magnetic Fe3O4 nanoparticles as a highly efficient catalyst for the synthesis of imidazoles under ultrasound irradiation
Javad Safari Zohre Zarnegar

To be fairly general and catalyst is easily separated by magnetic devices and can be reused without any apparent loss of activity for the reaction. Fe3O4 nanoparticles were prepared by chemical coprecipitation method and was found to be a mild and effective catalyst for چکیده کامل

To be fairly general and catalyst is easily separated by magnetic devices and can be reused without any apparent loss of activity for the reaction. Fe3O4 nanoparticles were prepared by chemical coprecipitation method and was found to be a mild and effective catalyst for the efficient, one-pot, three-component synthesis of 2,4,5-trisubstituted imidazoles at room temperature under ultrasound irradiation. The high yields of products and short reaction time were attributed to the nanosize of about 20 nm in which the catalyst could act as a nanoreactor. This methodology is found. پرونده مقاله

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35 - Ultrasound based method for one-pot synthesis of substituted imidazoles using SiO2-OSbCl2 as highly effective and reusable catalyst
Javad Safari Zohre Zarnegar Simin Naseh Zahra Akbari

A simple highly versatile and efficient sonochemical synthesis of 1,2,4,5-tetrasubstituted and 2,4,5-trisubstituted imidazoles is achieved by condensation of 1,2-dicarbonyl compound, aldehyde, ammonium acetate and primary amine using antimony trichloride immobilized on چکیده کامل

A simple highly versatile and efficient sonochemical synthesis of 1,2,4,5-tetrasubstituted and 2,4,5-trisubstituted imidazoles is achieved by condensation of 1,2-dicarbonyl compound, aldehyde, ammonium acetate and primary amine using antimony trichloride immobilized on silica gel (SiO2-OSbCl2) as a catalyst in ethanol at moderate temperature. Operational simplicity, practicability and applicability to various substrates make this method an interesting alternative to previously applied procedures. From the environmental standpoint, this eco-friendly green catalyst is stable, highly active, easy to prepare and handle. پرونده مقاله

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36 - Urea-hydrogen peroxide/silica phosphoric acid-catalyzed oxidation- condensation Tandem reaction: One-pot synthesis of 2-substituted benzimidazoles from alcohols
Ahmad Reza Momeni Heshmat Allah Samimi Reyhaneh Jahanian

An efficient one-pot oxidation/condensation tandem process has been developed for the synthesis of 2-substituted benzimidazole derivatives from benzylic alcohols and 1,2-phenylenediamine with use of urea-hydrogen peroxide/silica phosphoric acid as a bifunctional catalys چکیده کامل

An efficient one-pot oxidation/condensation tandem process has been developed for the synthesis of 2-substituted benzimidazole derivatives from benzylic alcohols and 1,2-phenylenediamine with use of urea-hydrogen peroxide/silica phosphoric acid as a bifunctional catalyst. This method provides a rapid and efficient access to 2-substituted benzimidazoles. پرونده مقاله

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37 - One-pot synthesis of 2,4,5-trisubstituted imidazoles catalyzed by dicationic magnetic room temperature ionic liquid
Bijan Mombani Godajdar Ali Reza Kiasat

Regarding the green chemistry's goals, dicationic magnetic room temperature ionic liquid open up new avenue to introduce an amazing and efficient system for facilitating catalyst recovery in different organic reactions. Ability of this dicationic magnetic room temperatu چکیده کامل

Regarding the green chemistry's goals, dicationic magnetic room temperature ionic liquid open up new avenue to introduce an amazing and efficient system for facilitating catalyst recovery in different organic reactions. Ability of this dicationic magnetic room temperature ionic liquid catalyst in the one-pot three-components condensation reaction of benzil, aromatic aldehyde, and ammonium acetatate are also described. Utilization of easy reaction conditions, catalyst with high catalytic activity and good reusability, and simple magnetically work-up, makes this methodology as an interesting option for the synthesis of 2,4,5-trisubstituted imidazoles. پرونده مقاله

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38 - Synthesis of tri and four substituted imidazoles derivatives using zinc oxid nanotubes modified by SiO2 as a powerful and reusable catalyst
Bijan Mombeni Godajdar Ebrahim Niknam

In recent years, zinc oxid nanotubes have attracted much attention. The direct use of , zinc oxidnanotubes modified by SiO2 as recoverable catalysts for organic reactions is very rare. The catalystswere characterized by XRD. The average particle size of ZnO catalysts is چکیده کامل

In recent years, zinc oxid nanotubes have attracted much attention. The direct use of , zinc oxidnanotubes modified by SiO2 as recoverable catalysts for organic reactions is very rare. The catalystswere characterized by XRD. The average particle size of ZnO catalysts is 57 nm and there are highdensitydefects on nanotubes surfaces . A simple and efficient method for the imidazol derivativessynthesis from the condensation benzil and ammonium acetate with substituted aromatic aldehydesin the presence of a catalytic amount zinc oxid nanotubes modified by SiO2 is described. The reasonproposed for higher catalytic activity of zinc oxid nanotubes modified by SiO2 is a combinationeffect of the small particle size and high-density surface defects. The practical and simple methodled to excellent yields of the tri and four substituted imidazoles derivatives under mild conditionsand within short times. پرونده مقاله

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39 - Synthesis and Antimicrobial Activity of 5-chloro-1-ethyl-2-methylimidazole-4-sulfonyl-8-Quinolinoxide
Oluwaseyi Ovonramwen Bodunde Owolabi Amowie Philip Oviawe Abiodun Falodun

10.22034/jchr.2020.1889510.1081

A new 5-chloro-1-ethyl-2-methylimidazole-4-sulfonyl-8-quinolinoxide was synthesized starting from diethyloxalate via a four-reaction step. The new compound obtained in a simple and efficient procedure in the solvent and solvent-free with good yield and methanol served a چکیده کامل

A new 5-chloro-1-ethyl-2-methylimidazole-4-sulfonyl-8-quinolinoxide was synthesized starting from diethyloxalate via a four-reaction step. The new compound obtained in a simple and efficient procedure in the solvent and solvent-free with good yield and methanol served as a precipitating agent to isolate compound 2. The purity of 5-chloro-1-ethyl-2-methylimidazole-4-sulfonyl-8-quinolinoxide was tested by thin-layer chromatography (TLC) and characterized by Fourier transform infrared spectroscopy (FT-IR), proton nuclear magnetic resonance (NMR), Carbon-13 (C13) nuclear magnetic resonance (13C-NMR), and DEPT 135 to confirm the presence and nature of CH2. The solvent-free reaction of compound 1 was better in relation to green chemistry and better yield. The presence of solvent responsible for a color change that differentiates between compound 1 and 2 as they have the same physical data, functional group, and the chemical shift studied. The newly synthesized compound was evaluated and screened in vitro against Gram-positive (methicillin-susceptible Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, and Bacillus subtilis), Gram-negative (Pseudomonas aeruginosa, Escherichia coli, and Klebsiella pneumoniae) bacterial strains, and Candida albicans using the standard microbiological method. 5-Chloro-1-ethyl-2-methylimidazole-4-sulfonyl-8-quinolinoxide exhibited weak activities when compared with the standard drug ciprofloxacin and itraconazole used for many bacterial and fungal infections respectively. پرونده مقاله

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40 - Synthesis, Characterization and Study the Biological Activity of Some New Heterocyclic Compounds Derived from Terephthalic Acid
Eman M. Hussain Rajaa K. Baqir Jumbad H. Tomma

10.22034/jchr.2023.1976713.1665

The organic compound imidazole has the chemical formula C3N2H4. Numerous significant biological compounds contain imidazole. The amino acid histidine is the most prevalent. The substituted imidazole derivatives have great potential for treating a variety of systemic fun چکیده کامل

The organic compound imidazole has the chemical formula C3N2H4. Numerous significant biological compounds contain imidazole. The amino acid histidine is the most prevalent. The substituted imidazole derivatives have great potential for treating a variety of systemic fungi infections. Thiourea is an organosulfur compound with the formula SC(NH2)2. It is a reagent in organic synthesis. In this paper, some new imidazole and thiourea derivatives are synthesized, characterized, and studied for their biological activity. These new compounds were synthesized from the starting material terephthalic acid, which was transformed to corresponding ester [I] by the refluxing of diacid with methanol in the presence of H2SO4 as a catalyst, compound [I] condensation with hydrazine hydrate 80% to yielded acid hydrazide [II], which was refluxed with 2 moles of various aromatic aldehydes in the presence of few drops of glacial acetic acid as a catalyst to yielded Schiff bases . Refluxing of chosen derivative with acetyl chloride in dry benzene gave new acetyl compounds which were reacted with thiourea and anhydrous sodium carbonate with acetone as a solvent to give new thiourea derivatives . Compounds were used to synthesize new imidazole derivatives by the reaction of appropriate compound with 2 moles of benzoin in dry DMF under cyclization reaction. FTIR, 1HNMR, and mass spectroscopy are used to characterize the synthesized compounds. پرونده مقاله

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41 - Multicomponent Reactions Synthesis of Triaryl-1H Imidazoles Using Reductive-oxidative Reactions by MnO2-FeSO4 as a Catalyst
Ali A.Raheem Ali T.Saleh

10.22034/jchr.2021.682034

The study's chief purpose is to investigate multicomponent reactions synthesis of triaryl-1h imidazoles using reductive-oxidative reactions by MnO2 - FeSO4 as a catalyst.Some novel substituted imidazoles have been synthesized using MCRs, one-pot synthesis, and MnO2/FeSO چکیده کامل

The study's chief purpose is to investigate multicomponent reactions synthesis of triaryl-1h imidazoles using reductive-oxidative reactions by MnO2 - FeSO4 as a catalyst.Some novel substituted imidazoles have been synthesized using MCRs, one-pot synthesis, and MnO2/FeSO4 as a catalyst; the method involves the reaction of benzil, aromatic aldehyde, and ammonium acetate in the presence of MnO2/FeSO4 as a reductive-oxidative catalyst under mild conditions. the obtained compounds were nontoxic, excellent yields, and environmentally friendly. The compounds were elucidated using IR and 1H-NMR spectra. To satisfy the aim of the study, Reactions have been performed simply by mixing 1,2-diketone with an aldehyde and ammonium acetate in the presence of the catalytic reagent of MnO2/FeSO4. The mixture was prepared by ground them together in a mortar with a pestle at room temperature for several minutes; after that, they purified by column chromatography, 2,4,5-triaryl substituted imidazole derivatives were obtained in excellent yields. پرونده مقاله

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