Biology and Chemistry of Benzimidazole Derivatives as Antiulcer Agents: A Review
محورهای موضوعی :
Geeta Yadav
1
(
Department of Pharmacy, Chandigarh Pharmacy College (CPC), Chandigarh Group of Colleges- CGC, Jhanjeri, Punjab-140307, India
)
کلید واژه: Benzimidazole, Imidazole, Heterocyclic, Proton pump inhibitors, Clinical drugs,
چکیده مقاله :
A flexible heterocyclic moiety found in many synthetic and natural compounds is benzimidazole. Because of its wide-ranging effects, it has drawn interest from researchers all around the world for the treatment of many illnesses. Many proton pump inhibitors that have received clinical approval have been available in the market since the discovery of Omeprazole in 1988, which was the first inhibitor based on benzimidazole. But the primary focus of research is on the necessity of pursuing specific goals in order to lessen the adverse effects of proton pump inhibitors. In order to achieve these goals, numerous different proton pump inhibitor medication combinations have also been tested. At the moment, clinical trials are being conducted on a few novel and inventive formulations. In order to set the stage for future investigations, a thorough analysis of antiulcer benzimidazoles was conducted. Researchers and academicians would find this review paper useful in their efforts to create less hazardous and more therapeutically active benzimidazoles. To the best of our knowledge, this study is the first attempt to compile important developments on benzimidazoles that have been suggested as antiulcer drugs.
A flexible heterocyclic moiety found in many synthetic and natural compounds is benzimidazole. Because of its wide-ranging effects, it has drawn interest from researchers all around the world for the treatment of many illnesses. Many proton pump inhibitors that have received clinical approval have been available in the market since the discovery of Omeprazole in 1988, which was the first inhibitor based on benzimidazole. But the primary focus of research is on the necessity of pursuing specific goals in order to lessen the adverse effects of proton pump inhibitors. In order to achieve these goals, numerous different proton pump inhibitor medication combinations have also been tested. At the moment, clinical trials are being conducted on a few novel and inventive formulations. In order to set the stage for future investigations, a thorough analysis of antiulcer benzimidazoles was conducted. Researchers and academicians would find this review paper useful in their efforts to create less hazardous and more therapeutically active benzimidazoles. To the best of our knowledge, this study is the first attempt to compile important developments on benzimidazoles that have been suggested as antiulcer drugs.
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