Benzimidazole

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1 - New Pt(II) Complexes with Heterocyclic Ligands Derived from Benzimidazole: Synthesis, Characterization, DFT Calculations and Catalytic Activities
Parisa Sadeghzadeh Mehdi Pordel Safar Ali Beyramabadi Abolghasem Davoodnia

In this work, the synthesis, spectral characterization, DFT calculations, and catalytic activity of thenew Pt(II) complexes with the ligand derived from benzimidazole derivatives have been described.The new heterocyclic ligands were obtained from the reaction of o-amino چکیده کامل

In this work, the synthesis, spectral characterization, DFT calculations, and catalytic activity of thenew Pt(II) complexes with the ligand derived from benzimidazole derivatives have been described.The new heterocyclic ligands were obtained from the reaction of o-amino-ketones with hydrazinehydrate in high yieldandPt(II) complexes prepared from the coordination of the new ligands toPt(II) cation. The new compounds have been characterized by spectral and microanalytical data.The DFT calculations at the B3LYP/6-311+G(d,p) level were also applied to gain further insightinto the geometry of Pt(II) complexes. The catalytic activity of Pt(II) complexes in Biginellireactionwas also examined as heterogeneous catalysts. The results showed that the 3,4-dihydropyrimidin-2(1H)-ones have been synthesized, in excellent yields, under solvent-free conditions, by reaction oftert-butyl acetoacetate, alcohol, arylaldehydes, and urea in the presence of Pt(II) complexes as anefficient and heterogeneous and catalyst. پرونده مقاله

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2 - New Benzimidazoles Derivatives: Synthesis, Characterization and Antifungal Activities
Abbas Ahmadi Babak Nahri-Niknafs

One of the most important goals in medicinal chemistry is the development of new heterocyclic compounds with pharmaceutical activity. Thus, a novel series of the derivatives of benzimidazole were synthesized and the structures of all the synthesized compounds have been چکیده کامل

One of the most important goals in medicinal chemistry is the development of new heterocyclic compounds with pharmaceutical activity. Thus, a novel series of the derivatives of benzimidazole were synthesized and the structures of all the synthesized compounds have been confirmed by IR, 1 H- and 13C-NMR, Mass Spectroscopy and elemental analysis. The title compounds have been evaluated for antifungal activities against Candida albicans, Candida glabrata, and Candida krusei. Some of these compounds have been found to exhibit moderate to good antifungal activity when compared with commercially available fungicides. پرونده مقاله

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3 - Co(II) تثبیت شده بر روی بستر مغناطیسی نانوفیبر سلولز آمین دار شده: یک نانوکاتالیزگر مغناطیسی ناهمگن جدید، زیستی و کارآمد برای سنتز مشتقات بنزایمیدازول
مهری سلیمی معصومه جعفرپور سوسن یزدانی شواکند فهیمه فیض پور

کبالت تثبیت شده بر روی نانوفیبر سلولز مغناطیسی عامل دار شده با آمین(Fe3O4@CNF-NH2- CoII) به عنوان یک نانوکاتالیزگر جدید مبتنی بر بستر زیستی سنتز شد. کاتالیزگر سنتز شده با طیف‌سنجی مادون قرمز-تبدیل فوریه(FT-IR)، میکروسکوپ الکترونی روبشی(SEM)، طیف‌سنجی پراش انرژی پرتو ایک چکیده کامل

کبالت تثبیت شده بر روی نانوفیبر سلولز مغناطیسی عامل دار شده با آمین(Fe3O4@CNF-NH2- CoII) به عنوان یک نانوکاتالیزگر جدید مبتنی بر بستر زیستی سنتز شد. کاتالیزگر سنتز شده با طیف‌سنجی مادون قرمز-تبدیل فوریه(FT-IR)، میکروسکوپ الکترونی روبشی(SEM)، طیف‌سنجی پراش انرژی پرتو ایکس(EDX)، میکروسکوپ الکترونی عبوری(TEM)، آنالیز وزن سنجی حرارتی(TGA)، مغناطیس‌سنجی نمونه ارتعاشی(VSM) و طیف سنجی نشر اتمی پلاسمای جفت شده القایی(ICP-OES) مشخصه یابی و مورفولوژی آن مورد بررسی قرار گرفت. این نانو کاتالیزگر مغناطیسی برای سنتز کارآمد مشتقات بنزایمیدازول از طریق واکنش تراکمی آلدهید های آروماتیک و آریل 2،1-دی آمین ها با استفاده از اتانول به عنوان حلال تحت اتمسفر هوا به خوبی عمل کرد. نانوکاتالیزگر فوق، به طور موفقیت آمیز توسط آهنربای خارجی تا 5 بار مورد بازیافت و بدون کاهش چشمگیر در فعالیت آن مورد استفاده مجدد قرار گرفت. استفاده ازحلال سبز در سنتز بنزایمیدازول ها، راندمان خوب تا عالی محصولات، استفاده ازکاتالیزگر قابل بازیافت بدون از دست دادن فعالیت کاتالیزگری، روش کارساده، این روش را ازنظر محیط زیستی و اقتصادی برای سنتزبنزایمیدازول ها مطلوب می کند. پرونده مقاله

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4 - سنتز کارآمد بنزیمیدازول ها در شرایط بدون حلال با استفاده از کمپلکس کیتوسان-مس (II) استخراج شده از پوسته میگوی خلیج فارس
یوسف دلشاد عبدالحمید دهقانی میلاد قزلسفلو سهیلا قاسمی

در این پژوهش، کاتالیزگری ارزان قیمت، دوست دار محیط زیست و قابل استفاده مجدد با روش مناسب سنتز شده است. برای این منظور، ابتدا ذرات کیتوسان از طریق فرایند استیل زدایی از ضایعات پوسته میگوی خلیج فارس تهیه شده و در ادامه کمپلکسی مبتنی بر مس بر روی بستری از ذرات کیتوسان با م چکیده کامل

در این پژوهش، کاتالیزگری ارزان قیمت، دوست دار محیط زیست و قابل استفاده مجدد با روش مناسب سنتز شده است. برای این منظور، ابتدا ذرات کیتوسان از طریق فرایند استیل زدایی از ضایعات پوسته میگوی خلیج فارس تهیه شده و در ادامه کمپلکسی مبتنی بر مس بر روی بستری از ذرات کیتوسان با موفقیت بدست آمد. ساختار کمپلکس کیتوسان-مس(II)، با استفاده از روش های گوناگون از قبیل طیف سنجی مادون قرمز تبدیل فوریه، پراش پرتو ایکس، میکروسکوپ الکترونی روبشی، طیف سنجی پراش انرژی پرتو ایکس و طیف سنجی مرئی- فرابنفش تایید شد. با توجه به کاربرد وسیع بنزیمیدازول ها در صنعت و داروسازی، خواص کاتالیزگری کمپلکس کیتوسان-مس (II)سنتز شده، در واکنش دو جزئی سنتز مشتق های مختلف بنزیمیدازول تحت شرایط بدون حلال مطالعه شد. استفاده از کاتالیزگر کمپلکس کیتوسان-مس(II)، در سنتز مشتقات بنزیمدازول چندین مزیت از جمله بازده قابل توجه، شرایط واکنش ملایم، زمان سنتز کوتاه، جداسازی آسان کاتالیزگر و اجتناب از تولید زباله های سمی را نشان داد. علاوه بر این، کمپلکس کیتوسان-مس(II) به راحتی توسط صاف کردن بازیابی شد و می‌توان آن را برای پنج چرخه بدون از دست دادن فعالیت کاتالیزگری مورد استفاده ی مجدد قرار داد. پرونده مقاله

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5 - 5-sulfosalicylic acid as an efficient organocatalyst for environmentally benign synthesis of 2-substituted benzimidazoles
Chandrakant Bhenki Shrikrishna Karhale Vasant Helavi

A water soluble, Bronsted acid, 5-sulfosalicylic acid as an efficient organocatalyst was used for the synthesis of physiologically active 2-substituted benzimidazole derivatives from o-phenylenediamine and aromatic aldehydes in ethanol at reflux condition. Cost-effectiv چکیده کامل

A water soluble, Bronsted acid, 5-sulfosalicylic acid as an efficient organocatalyst was used for the synthesis of physiologically active 2-substituted benzimidazole derivatives from o-phenylenediamine and aromatic aldehydes in ethanol at reflux condition. Cost-effectiveness, use of non-hazardous solvents, metal free and commercially available catalyst, single-step, environmentally friendly green method, high conversions, cleaner reaction profiles and simple experimental and workup procedures are the remarkable features of this method. A water soluble, Bronsted acid, 5-sulfosalicylic acid as an efficient organocatalyst has been used for the synthesis of physiologically active 2-substituted benzimidazole derivatives from o-phenylenediamine and aromatic aldehydes in ethanol at reflux condition. Cost-effectiveness, use of non-hazardous solvents, metal free and commercially available catalyst, single step, environmentally friendly green method, high conversions, cleaner reaction profiles and simple experimental and workup procedures are the remarkable features of this method. پرونده مقاله

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6 - Synthesis of benzimidazole derivatives using Ni2+ supported on hydroxyapatite-core@shell γ-Fe2O3 nanoparticles both under solvent and solvent-free conditions
Eshagh Rezaee Nezhad Saaid Karimian

Ni2+ supported on hydroxyapatite-core@shell γ-Fe2O3 nanoparticles (γ-Fe2O3@HAp-Ni2+) was found to be a useful catalyst for the synthesis of benzimidazole derivatives from o-phenylenediamine and aldehydes under solvent and solvent-free conditions at 80 °C چکیده کامل

Ni2+ supported on hydroxyapatite-core@shell γ-Fe2O3 nanoparticles (γ-Fe2O3@HAp-Ni2+) was found to be a useful catalyst for the synthesis of benzimidazole derivatives from o-phenylenediamine and aldehydes under solvent and solvent-free conditions at 80 °C. This reaction affords the corresponding benzimidazole derivatives compared with the classical reactions this method consistently gives a high yield, easy magnetic separation, a short reaction time, simple workup and recyclable property of the catalyst. In this way, the catalyst was readily recovered using an external magnet and could be reused in five consecutive runs without significant loss of reactivity. The mean size and the surface morphology of the nanocatalyst were characterized by TEM, SEM, VSM, XRD and FTIR techniques. پرونده مقاله

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7 - Spotlight: Use of heterogeneous catalysts in benzimidazole synthesis
Elham Amouhadi

Elham Amouhadi was born in 1983 in Esfahan, Iran. She received her B.Sc. in Applied Chemistry (2005) and M.Sc. in Inorganic Chemistry (2016) from Islamic Azad University Shahreza Branch. She is currently working towards her Ph.D. under the supervision of Professor Razie چکیده کامل

Elham Amouhadi was born in 1983 in Esfahan, Iran. She received her B.Sc. in Applied Chemistry (2005) and M.Sc. in Inorganic Chemistry (2016) from Islamic Azad University Shahreza Branch. She is currently working towards her Ph.D. under the supervision of Professor Razieh Fazaeli at Islamic Azad University Shahreza Branch. Her research interest is the design, synthesis, and characterization of Inorganic Catalysts. پرونده مقاله

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8 - Trifluoroacetate-bonded polyethylene graphene oxide composite as a novel and efficient catalyst for the synthesis of benzimidazoles under solvent-free conditions
Esmael Rostami Seyed Mahdi Haghayeghi

A green and efficient trifluoroacetate-bonded polyethylene graphene oxide composite was utilized in this research to prepare benzimidazoles with good to excellent yield under a solvent-free condition. The trifluoroacetate-bonded polyethylene graphene oxide composite was چکیده کامل

A green and efficient trifluoroacetate-bonded polyethylene graphene oxide composite was utilized in this research to prepare benzimidazoles with good to excellent yield under a solvent-free condition. The trifluoroacetate-bonded polyethylene graphene oxide composite was constructed by polyethylene/diethylenetriamine-functionalized graphene oxide composite bonded by 2-aminothiazole and CF3COOHmoieties. Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD) analysis, field emission scanning electron microscopy (FESEM), energy dispersive x-ray spectroscopy (EDS), and thermogravimetric analysis (TGA) were also employed to characterize the composite. Benzimidazoles were synthesized by reacting 1,2-phenylenediamine with aromatic aldehydes in the presence of composite (0.02 g) under solvent-free conditions at 75°C. The composite was recovered and used in five runs without considerable loss of activity. Compared to the other catalysts employed for the synthesis of benzimidazole, the present composite (catalyst) benefits from a series of advantages such as cost-effectiveness, easy storage and handling, recoverability and durability, environmental friendliness, non-metallic nature, and ease of disposal. The present synthetic route has also some advantages, including, moderate condition, easy workup, solvent-free nature, and environmental safety. پرونده مقاله

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9 - Trans-3,5-dihydroperoxy-3,5-dimethyl-1,2-dioxolane/HOAc/KI system as a new and mild catalyst for efficient synthesis of 1H-benzimidazoles and 1H-benzothiazoles in water
Kaveh Khosravi Akbar Mobinikhaledi Samira Kazemi Davood Azarifar Payam Rahmani

An efficient method has been developed for the catalysis of condensation of 1,2-phenylenediamines and 2-aminothiophenoles with different aldehydes into their corresponding 2-aryl-1H-benzimidazoles and 2-aryl-1H-benzothiazoles under mild condition. In this method, trans- چکیده کامل

An efficient method has been developed for the catalysis of condensation of 1,2-phenylenediamines and 2-aminothiophenoles with different aldehydes into their corresponding 2-aryl-1H-benzimidazoles and 2-aryl-1H-benzothiazoles under mild condition. In this method, trans-3,5-dihydroperoxy-3,5-dimethyl-1,2-dioxolane (DHPDMDO)/HOAc/KI system was used as a novel and effective oxidant in water at room temperature with excellent results. پرونده مقاله

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10 - Synthesis of 2-Substitued Benzimidazoles Using P2O5-SiO2
Ahmad Reza Momeni Somayeh Bagheri

P2O5-SiO2 (30% w/w) was found to be a useful catalyst for the synthesis of various 2-substituted aryl benzimidazoles under solvent-less and in solvent conditions from o-phenylenediamine and aldehydes. The products were directly recrystallized from methanol.

P2O5-SiO2 (30% w/w) was found to be a useful catalyst for the synthesis of various 2-substituted aryl benzimidazoles under solvent-less and in solvent conditions from o-phenylenediamine and aldehydes. The products were directly recrystallized from methanol. پرونده مقاله

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11 - Urea-hydrogen peroxide/silica phosphoric acid-catalyzed oxidation- condensation Tandem reaction: One-pot synthesis of 2-substituted benzimidazoles from alcohols
Ahmad Reza Momeni Heshmat Allah Samimi Reyhaneh Jahanian

An efficient one-pot oxidation/condensation tandem process has been developed for the synthesis of 2-substituted benzimidazole derivatives from benzylic alcohols and 1,2-phenylenediamine with use of urea-hydrogen peroxide/silica phosphoric acid as a bifunctional catalys چکیده کامل

An efficient one-pot oxidation/condensation tandem process has been developed for the synthesis of 2-substituted benzimidazole derivatives from benzylic alcohols and 1,2-phenylenediamine with use of urea-hydrogen peroxide/silica phosphoric acid as a bifunctional catalyst. This method provides a rapid and efficient access to 2-substituted benzimidazoles. پرونده مقاله

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