Exploring the biological potential of Cruciata taurica (Pall. ex Willd.) Ehrend.: Evaluating antibacterial, antioxidant, antidiabetic, and cytotoxic properties
Subject Areas : Medicinal and Herbal PlantsShiva Khalil-Moghaddam 1 , Roya Moghimi 2 , Thomas Efferth 3 , Sajedeh Mousavian 4
1 - Department of Biology, Yadegar-e-Imam Khomeini (RAH), Shahre Rey Branch, Islamic Azad University, Tehran, Iran
2 - Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran
3 - Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University Mainz, Germany
4 - Departmant of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
Keywords: Bioactivity, Cancer, Cruciata taurica (Pall. ex Willd.) Ehrend., Cytotoxic, Ethnopharmacology, Multidrug resistance, Plant extract,
Abstract :
This study focused on the biological properties of Cruciata taurica, a plant found in the Irano-Turanian region, which has not been extensively studied in terms of its phytochemical and biological activities. The methanolic extract of the plant was obtained and its cytotoxic, antibacterial, antidiabetic, and antioxidant properties were investigated. The antibacterial activity of the fractions was evaluated using broth microdilution method, while the antioxidant properties were assessed through the DPPH assay and the cytotoxic properties were determined using the RRA assay. This study revealed that the residual aqueous fraction exhibited the highest extraction yield and the most potent antioxidant activity. The EtOAc fraction showed strong antibacterial activity against certain bacteria, while the n-hexane fraction exhibited greater antidiabetic effects. Additionally, the EtOAc fraction was found to be the most cytotoxic. Overall, the study suggested that C. taurica has potential therapeutic applications due to its various biological properties.
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