Novel synthesis of Pyrimido[4,5- e] [1,3,4] thiadiazines as potential 15- lipoxygenase inhibitors

Subject Areas : Journal of the Iranian Chemical Research

Abdolhassan Doulah ¹ , Masoud Mirzaei ² , Mohsen Nikpour ³ , Yaghoub Farbood ⁴

1 - Department of Nursing, Faculty of Nursing and Midwifery, Islamic Azad University, Ahvaz Branch, Ahvaz 6134968875, Iran
2 - Department of Chemistry, School of Sciences, Ferdowsi University of Mashhad, Mashhad, 91775-1436, Iran
3 - Department of Chemistry, School of Sciences, Islamic Azad University, Ahvaz Branch, Ahvaz, 6134968875, Iran
4 - Physiology Research Center and Department Physiology, Medicine Faculty, Ahwaz Jondishapour University of Medical Sciences, Ahwaz, Iran

Received: 2011-02-03 Accepted : 2011-03-25 Published : 2011-03-31

Keywords: 1-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-1-methylhydrazine, Dimethylthio carbamoylchloride, pyrimidothiadiazine, Cyclocondensation,

Abstract :

Treatment of 1-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-1-methylhydrazine withdimethylthiocarbamoylchloride gave 7-chloro-N,N, 1,5-tetramethyl-1H-pyrimido[4,5-e][1,3,4]thiadiazin-3-amine in basic acetonitrile. The latter compounds were reacted withsecondary amines in boiling ethanol to afford the related 7-amino derivatives.

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