Journal of the Iranian Chemical Research: 2 (2)

Open Access Article

1 - UV-Visible spectrophotometry of Repaglinide in bulk and in formulation by using methyl orange as reagents
Smita Sharma Mukesh Sharma

Two sensitive spectrophotometric methods are presented for the assay of Repaglinide in bulkdrug and in formulations using methyl orange, as reagents. Oxidant by reacting with a fixedamount of either methyl orange and measuring the absorbance at 485.2 nm (method-I) andme More

Two sensitive spectrophotometric methods are presented for the assay of Repaglinide in bulkdrug and in formulations using methyl orange, as reagents. Oxidant by reacting with a fixedamount of either methyl orange and measuring the absorbance at 485.2 nm (method-I) andmeasuring the absorbance at 618.9 nm (method-II). Developed method is based on the formationof extractable colored complex of drug with coloring agent Methyl orange dye. A wavelengthmaximum was found to be 618.9 nm. The concentration range of 15-50 μg ml-1 with linearregression of 0.9995, while the percentage recovery, LOD and LOQ were 99.42-99.08 %, 2.17μg ml-1 and 1.08 μg ml-1 respectively. The result of analysis have been validated statistically andalso by recovery studies. From the percentage recovery and specificity studies it was concludedthat there was no interference of common additives during the estimation. This proves thesuitability of this method for the routine quality control analysis of the Repaglinide informulation. Manuscript profile

Open Access Article

2 - The effect of temperature and water absorption on enzymatic degradation of starch / polyvinyl alcohol blend film by α-Amylase
Mohammad Taghi Taghizadeh Zahra Abbasi

Thermoplastic starch (TPS) materials present several advantages to the plastic industry andwhen blended with other materials they can exhibit improved mechanical and moisturesensitivity properties compared to pure TPS materials. Further investigations on TPS: PVAblends More

Thermoplastic starch (TPS) materials present several advantages to the plastic industry andwhen blended with other materials they can exhibit improved mechanical and moisturesensitivity properties compared to pure TPS materials. Further investigations on TPS: PVAblends are of particular interest due to their excellent compatibility and improved properties suchas tensile strength, elongation, toughness and processability, predominantly due to animprovement in melt strength compared to pure TPS material. The aims of the study were toinvestigate the effect of varying polyvinyl alcohol content within the TPS blends on the rate andextent of starch enzymatic hydrolysis using enzyme alpha-amylase. Analyses the enzymaticdegradation behavior of poly(vinyl alcohol) with starch was based on the determinations ofWeight loss and the reducing sugars. The degraded residues have been examined by FT-IRspectroscopy and scanning electronic microscopy (SEM). Manuscript profile

Open Access Article

3 - Determination of mercury (II) by spectrophotometric method based on self assembly of gold nanoparticles
Yan Du Jing Yan Mei Ni Bao Du

Due to the binding of the –COO- group with the mercury (II), gold nanoparticlesfunctionalized with glutathione can self-assemble to form a supermolecular network in the HAc-NaAc buffer solution. The aggregation of functionalized gold nanoparticles and mercury (II) More

Due to the binding of the –COO- group with the mercury (II), gold nanoparticlesfunctionalized with glutathione can self-assemble to form a supermolecular network in the HAc-NaAc buffer solution. The aggregation of functionalized gold nanoparticles and mercury (II)caused the shift of maximum absorption peak of the UV-Vis spectrum from 520 nm to 609 nm.Based on this principle, a simple spectrophotometric method for determination of mercury (II)was preliminarily established. The detection limit of the developed method for determination ofmercury (II) was about 8.5×10-8 mol L-1. Manuscript profile

Open Access Article

4 - Novel synthesis of Pyrimido[4,5- e] [1,3,4] thiadiazines as potential 15- lipoxygenase inhibitors
Abdolhassan Doulah Masoud Mirzaei Mohsen Nikpour Yaghoub Farbood

Treatment of 1-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-1-methylhydrazine withdimethylthiocarbamoylchloride gave 7-chloro-N,N, 1,5-tetramethyl-1H-pyrimido[4,5-e][1,3,4]thiadiazin-3-amine in basic acetonitrile. The latter compounds were reacted withsecondary amines in b More

Treatment of 1-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-1-methylhydrazine withdimethylthiocarbamoylchloride gave 7-chloro-N,N, 1,5-tetramethyl-1H-pyrimido[4,5-e][1,3,4]thiadiazin-3-amine in basic acetonitrile. The latter compounds were reacted withsecondary amines in boiling ethanol to afford the related 7-amino derivatives. Manuscript profile

Open Access Article

5 - Prediction of melting points of a diverse chemical set using fuzzy regression tree
Vali Zare-Shahabadi

The classification and regression trees (CART) possess the advantage of being able to handlelarge data sets and yield readily interpretable models. In spite to these advantages, they are alsorecognized as highly unstable classifiers with respect to minor perturbations i More

The classification and regression trees (CART) possess the advantage of being able to handlelarge data sets and yield readily interpretable models. In spite to these advantages, they are alsorecognized as highly unstable classifiers with respect to minor perturbations in the training data.In the other words methods present high variance. Fuzzy logic brings in an improvement in theseaspects due to the elasticity of fuzzy sets formalism. ACS, which is a meta-heuristic algorithmand derived from the observation of real ants, was used to optimize fuzzy parameters. Thepurpose of this study was to explore the use of fuzzy regression tree (RT) for modeling ofmelting points of a large variety of chemical compounds. To test the ability of the resulted tree, aset of approximately 4173 structures and their melting points were used (3000 compounds astraining set and 1173 as validation set). Further, an external test set contains of 277 drugs wereused to validate the prediction ability of the tree. Comparison the results obtained from both treesshowed that the fuzzy RT performs better than that produced by recursive partitioning procedure. Manuscript profile

Open Access Article

6 - Design novel optical sensor for determination of bismuth based on immobilization of 4-(4-nitrophenyl)-1-naphthol on a triacetylcellulose membrane
Ali Niazi Shiva Karimi Afshar

A novel optical sensor has been proposed for sensitive determination of bismuth ion basedon immobilization of 4-(4-nitrophenylazo)-1-naphthol on a triacetylcellulose membrane.Chemical binding of bismuth ions in solution with a 4-(4-nitrophenylazo)-1-naphtholimmobilized More

A novel optical sensor has been proposed for sensitive determination of bismuth ion basedon immobilization of 4-(4-nitrophenylazo)-1-naphthol on a triacetylcellulose membrane.Chemical binding of bismuth ions in solution with a 4-(4-nitrophenylazo)-1-naphtholimmobilized on the triacetylcelluse surface could be monitored spectrophotometrically. Theoptode shows excellent response over wide concentration range 0.4-3.6 μg mL-1 bismuth with alimit of detection of 0.14 μg mL-1 bismuth. The influence of factors responsible for the improvedsensitivity of the sensor were studied and identified. The response time of the optode was 30 secfor a stirrer solution. The influence of potential interfering ions on the determination of 0.4 μgmL-1 bismuth was studied. The proposed optode was applied to the determination of bismuth inpharmaceutical formulation samples. Manuscript profile

Open Access Article

7 - Tautomeric equilibria for ionized oxamic acid - inhibitor of LDH
Ewa D. Raczyńska Małgorzata Hallmann Kinga Duczmal

Amide-iminol tautomerism was studied for ionized oxamic acid (OA+•) in the gas phase using theDFT method with the UB3LYP functional and various basis sets {6-31++G(d,p), 6-311+G(d,p), and augcc-pVDZ}. Among twenty tautomers-rotamers possible for OA+•, eleven i More

Amide-iminol tautomerism was studied for ionized oxamic acid (OA+•) in the gas phase using theDFT method with the UB3LYP functional and various basis sets {6-31++G(d,p), 6-311+G(d,p), and augcc-pVDZ}. Among twenty tautomers-rotamers possible for OA+•, eleven isomers were found to bethermodynamically stable. Similarly as for the neutral molecule, ionization (OA → OA+• + e) favors theamidization process (amide ← iminol). Isomerization seems to change solely the conformationalpreferences. π-Electron delocalization in the NCO and OCO moieties is close to that for n-π conjugatedfragments. Manuscript profile

Open Access Article

8 - Convenient method for synthesis of a carbon-14 analogue of DL-Phenyl alanine
Gholamhossien Shirvani Nader Saemian Mohsen Javaheri

DL-Phenyl alanine labeled with carbon-14 in the α-position has been synthesized from ethyl[2-14C] acetate as part of a 6-step sequence.

DL-Phenyl alanine labeled with carbon-14 in the α-position has been synthesized from ethyl[2-14C] acetate as part of a 6-step sequence. Manuscript profile

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