A review on hepatoprotective effects of Nigella sativa L.
Subject Areas : Journal of Medicinal Herbs, "J. Med Herb" (Formerly known as Journal of Herbal Drugs or J. Herb Drug)مهرداد استادپور 1 , مجید غلامی آهنگران 2
1 - فارغ التحصیل دانشکده دامپزشکی ، واحد شهرکرد ، دانشگاه آزاد اسلامی ، شهرکرد ، ایران
2 - گروه علوم بالینی ، دانشکده دامپزشکی ، واحد شهرکرد ، دانشگاه آزاد اسلامی ، شهرکرد ، ایران
Keywords: Toxicity, Nigella sativa, Thymoquinone, Black seeds, Hepatoprotective,
Abstract :
Background & Aim:Nigella sativa L. (Black seeds) which is a member of the Ranunculaceae family, grows in Southwestern Asia, Europe, and Northern Africa. The use ofN. Sativaseeds and oil in traditional remedies goes back more than 2000 years, and the herb is described as ‘the Melanthion’ by hippocrates and dioscorides.Experimental: In the current literature review, key words including N. Sativa, thymoquinone, black seeds, toxicity, protection of hepatocellular were searched in scientific websites such as Science Direct, PubMed, Google Scholar etc. to compile the protective effects of N. Sativaagainst hepatocellular damage.Results: Many active components of N. Sativahave been identified, including thymoquinone, dithymoquinone, thymohydroquinone, nigellone, melanthin, nigilline, nigelamine, damascenone, p -cymene and pinene. N. Sativais a medicinal plant with antifungal, anti-viral, anti-bacterial, anti-parasite, anti-oxidant, analgesic, antipyretic, anti-tussive, and anti-inflammatory properties. Thymoquinone could prevent many disorders such as neurobehavioral kidney and liver disorders. N. Sativawas also found to be able to relieve the symptoms of patients with several diseases, such as hypertension, dyslipidemia, metabolic syndrome, diabetes and natural and chemical toxicities.Recommended applications/industries: According to literature,N. Sativatreatment will decrease the elevated lipid peroxidation, liver enzyme levels and increase antioxidant enzyme levels. N. Sativaadministration can also protect hepatic tissue from deleterious effects of toxic metals.
A Hagag, A., M AbdElaal, A., S Elfaragy, M., M Hassan, S. and A Elzamarany, E. 2015. Therapeutic value of black seed oil in methotrexate hepatotoxicity in Egyptian children with acute lymphoblastic leukemia. Infectious Disorders-Drug Targets (Formerly Current Drug Targets-Infectious Disorders), 15(1):64-71.
Abdel-Daim, M.M. and Ghazy, E.W. 2015. Effects of Nigella sativa oil and ascorbic acid against oxytetracycline-induced hepato-renal toxicity in rabbits. Iranian Journal of Basic Medical Sciences, 18(3):221-227.
Abdel-Wahab, W.M. 2014. Thymoquinone attenuates toxicity and oxidative stress induced by bisphenol A in liver of male rats. Pakistan journal of biological sciences: PJBS, 17(11):1152-1160.
AbuKhader, M.M. 2013. Thymoquinone in the clinical treatment of cancer: Fact or fiction? Pharmacognosy Reviews, 7(14):117-222.
Ahmad, A., Husain, A., Mujeeb, M., Khan, S.A., Najmi, A.K., Siddique, N.A., Damanhouri, Z.A. and Anwar, F. 2013. A review on therapeutic potential of Nigella sativa: A miracle herb. Asian Pacific journal of tropical biomedicine, 3(5):337-352.
Ali, B.H. and Blunden, G. 2003. Pharmacological and toxicological properties of Nigella sativa. Phytotherapy Research: An international journal devoted to pharmacological and toxicological evaluation of natural product derivatives, 17(4):299-305.
Aljabre, S.H., Alakloby, O.M. and Randhawa, M.A. 2015. Dermatological effects of Nigella sativa. Journal of dermatology & dermatologic surgery, 19(2):92-98.
Amin, B. and Hosseinzadeh, H. 2016. Black cumin (Nigella sativa) and its active constituent, thymoquinone: an overview on the analgesic and anti-inflammatory effects. Planta medica, 82(1-2):8-16.
Amin, B., Taheri, M.M.H. and Hosseinzadeh, H. 2014. Effects of intraperitoneal thymoquinone on chronic neuropathic pain in rats. Planta medica, 80(15):1269-1277.
Banerjee, S., Padhye, S., Azmi, A., Wang, Z., Philip, P.A., Kucuk, O., Sarkar, F.H. and Mohammad, R.M. 2010. Review on molecular and therapeutic potential of thymoquinone in cancer. Nutrition and cancer, 62(7):938-946.
Cherif, M., Valenti, B., Abidi, S., Luciano, G., Mattioli, S., Pauselli, M., Bouzarraa, I., Priolo, A. and Salem, H.B. 2018. Supplementation of Nigella sativa seeds to Barbarine lambs raised on low-or high-concentrate diets: Effects on meat fatty acid composition and oxidative stability. Meat science, 139:134-141.
Daba, M.H. and Abdel-Rahman, M.S. 1998. Hepatoprotective activity of thymoquinone in isolated rat hepatocytes. Toxicology letters, 95(1):23-29.
Darakhshan, S., Pour, A.B., Colagar, A.H. and Sisakhtnezhad, S. 2015. Thymoquinone and its therapeutic potentials. Pharmacological research, 95:138-158.
El-Gharieb, M.A., El-Masry, T.A., Emara, A.M. and Hashem, M.A. 2010. Potential hepatoprotective effects of vitamin E and Nigella sativa oil on hepatotoxicity induced by chronic exposure to malathion in human and male albino rats. Toxicological & Environ Chemistry, 92(2):391-407.
EL‐Kholy, W.M., Hassan, H.A., Nour, S.E., Abe Elmageed, Z.E. and Matrougui, K. 2009. Hepatoprotective effects of Nigella sativa and bees' honey on hepatotoxicity induced by administration of sodium nitrite and sunset yellow. The FASEB Journal, 23:733-2.
ERDOĞAN, Ü., YILMAZER, M. and ERBAŞ, S. 2020. Hydrodistillation of Nigella sativa seed and analysis of Thymoquinone with HPLC and GC-MS. Bilge International Journal of Science and Technology Research, 4(1):27-30.
Forouzanfar, F., Bazzaz, B.S.F. and Hosseinzadeh, H. 2014. Black cumin (Nigella sativa) and its constituent (thymoquinone): a review on antimicrobial effects Iranian Journal of Basic Medical Sciences, 17(12):929.
Gani, M.S. and John, S.A. 2013. Evaluation of hepatoprotective effect of Nigella sativa L. International Journal of Pharmacy and Pharmaceutical Sciences, 5(4):428-430.
Gholamnezhad, Z., Keyhanmanesh, R. and Boskabady, M.H. 2015. Anti-inflammatory, antioxidant, and immunomodulatory aspects of Nigella sativa for its preventive and bronchodilatory effects on obstructive respiratory diseases: A review of basic and clinical evidence. Journal of Functional Foods, 17:910-927.
Hariharan, P., Paul‐Satyaseela, M. and Gnanamani, A. 2016. In vitro profiling of antimethicillin‐resistant Staphylococcus aureus activity of thymoquinone against selected type and clinical strains. Letters in Applied Microbiology, 62(3):283-289.
Hassan, A.S., Ahmed, J.H. and Al-Haroon, S.S. 2012. A study of the effect of Nigella sativa (Black seeds) in isoniazid (INH)-induced hepatotoxicity in rabbits. Indian Journal of Pharmacology, 44(6):678.
Havakhah, S., Sadeghnia, H.R., Mosa-Al-Reza Hajzadeh, N.M., Roshan, S.S., Hosseinzadeh, H., Mohareri, N. and Rad, A.K. 2014. Effect of Nigella sativa on ischemia-reperfusion induced rat kidney damage. Iranian journal of basic medical sciences, 17(12):986-994.
Hosseini, S.M., Taghiabadi, E., Abnous, K., Hariri, A.T., Pourbakhsh, H. and Hosseinzadeh, H. 2017. Protective effect of thymoquinone, the active constituent of Nigella sativa fixed oil, against ethanol toxicity in rats. Iranian Journal of Basic Medical Sciences, 20(8):927.
Hosseinzadeh, H., Eskandari, M. and Ziaee, T. 2008. Antitussive effect of thymoquinone, a constituent of Nigella sativa seeds, in guinea pigs. Pharmacologyonline, 2:480-484.
Hosseinzadeh, H., Moghim, F.F. and Mansouri, S.M.T. 2007. Effect of Nigella sativa seed extracts on ischemia-reperfusion in rat skeletal muscle. Pharmacologyonline, 2:326-335.
Hosseinzadeh, H. and Montahaei, R. 2007. Protective effect of Nigella sativa L. extracts and thymoquinone, its active constituent, on renal ischemia-reperfusion-induced oxidative damage in rats. Pharmacologyonline, 1:176-189.
Hosseinzadeh, H., Parvardeh, S., Asl, M.N., Sadeghnia, H.R. and Ziaee, T. 2007. Effect of thymoquinone and Nigella sativa seeds oil on lipid peroxidation level during global cerebral ischemia-reperfusion injury in rat hippocampus. Phytomedicine, 14(9):621-627.
Hosseinzadeh, H., Taiari, S. and Nassiri-Asl, M. 2012. Effect of thymoquinone, a constituent of Nigella sativa L., on ischemia–reperfusion in rat skeletal muscle. Naunyn-Schmiedeberg's archives of pharmacology, 385(5):503-508.
Javidi, S., Razavi, B.M. and Hosseinzadeh, H. 2016. A review of neuropharmacology effects of Nigella sativa and its main component, thymoquinone. Phytotherapy research, 30(8):1219-1229.
Kanter, M., Coskun, O. and Budancamanak, M. 2005. Hepatoprotective effects of Nigella sativa L and Urtica dioica L on lipid peroxidation, antioxidant enzyme systems and liver enzymes in carbon tetrachloride-treated rats. World Journal of Gastroenterology, 11(42): 6684.
Kapoor, S. 2009. Emerging clinical and therapeutic applications of Nigella sativa in gastroenterology. World Journal of Gastroenterology, 15(17):2170.
Karimi, Z., Alizadeh, A.M., Dolatabadi, J.E.N. and Dehghan, P. 2019. Nigella sativa and its Derivatives as Food Toxicity Protectant Agents. Advanced Pharmaceutical Bulletin, 9(1):22-28
Karna, S.K.L. 2013. Phytochemical screening and gas chromatography mass spectrometry and analysis of seed extract of Nigella sativa Linn. Int J Chem Studies, 1(4):183-188.
Khan, A., Chen, H.C., Tania, M. and Zhang, D.Z. 2011. Anticancer activities of Nigella sativa (black cumin). African Journal of Traditional, Complementary and Alternative Medicines, 8(5): 100-110.
Manju, S., Malaikozhundan, B., Vijayakumar, S., Shanthi, S., Jaishabanu, A., Ekambaram, P. and Vaseeharan, B. 2016. Antibacterial, antibiofilm and cytotoxic effects of Nigella sativa essential oil coated gold nanoparticles. Microbial pathogenesis, 91:129-135.
Mansour, M.A., Ginawi, O.T., El-Hadiyah, T., El-Khatib, A.S., Al-Shabanah, O.A. and Al-Sawaf, H.A. 2001. Effects of volatile oil constituents of Nigella sativa on carbon tetrachloride-induced hepatotoxicity in mice: evidence for antioxidant effects of thymoquinone. Research Communications in Molecular Pathology and Pharmacology, 110 (3-4):239-252.
Mansour, M.A. 2000. Protective effects of thymoquinone and desferrioxamine against hepatotoxicity of carbon tetrachloride in mice. Life Sciences, 66(26): 2583-2591.
Mehri, S., Shahi, M., Razavi, B.M., Hassani, F.V. and Hosseinzadeh, H. 2014. Neuroprotective effect of thymoquinone in acrylamide-induced neurotoxicity in Wistar rats. Iranian Journal of Basic Medical Sciences, 17(12): 1007-1010.
Mollazadeh, H. and Hosseinzadeh, H. 2014. The protective effect of Nigella sativa against liver injury: a review. Iranian journal of basic medical sciences, 17(12):958.
Nadaf, N.H., Gawade, S.S., Muniv, A.S., Waghmare, S.R., Jadhav, D.B. and Sonawane, K.D. 2015. Exploring anti-yeast activity of Nigella sativa seed extracts. Industrial Crops and Products, 77:624-630.
Noorbakhsh, M.F., Hayati, F., Samarghandian, S., Shaterzadeh-Yazdi, H. and Farkhondeh, T., 2018. An overview of hepatoprotective effects of thymoquinone. Recent patents on food, nutrition & agriculture, 9(1): 14-22.
Pourbakhsh, H., Taghiabadi, E., Abnous, K., Hariri, A.T., Hosseini, S.M. and Hosseinzadeh, H. 2014. Effect of Nigella sativa fixed oil on ethanol toxicity in rats. Iranian Journal of Basic Medical Sciences, 17(12):1020-1028.
Razavi, B.M. and Hosseinzadeh, H. 2014. A review of the effects of Nigella sativa L. and its constituent, thymoquinone, in metabolic syndrome. Journal of Endocrinological Investigation, 37(11):1031-1040.
Shabana, A., El-Menyar, A., Asim, M., Al-Azzeh, H. and Al Thani, H. 2013. Cardiovascular benefits of black cumin (Nigella sativa). Cardiovascular Toxicology, 13(1):9-21.
Simalango, D.M. and Utami, N.V. 2014. In-vitro antihelminthic effect of ethanol extract of black seeds (Nigella sativa) against Ascaris suum. Procedia Chem, 13:181-185.
Tabassum, H., Ahmad, A. and Ahmad, I.Z. 2018. Nigella sativa L. and its bioactive constituents as Hepatoprotectant: a review. Current pharmaceutical biotechnology, 19(1):43-67.
Yildiz, F., Coban, S., Terzi, A., Ates, M., Aksoy, N., Cakir, H., Ocak, A.R. and Bitiren, M. 2008. Nigella sativa relieves the deleterious effects of ischemia reperfusion injury on liver. World journal of Gastroenterology, 14(33):5204-5210.
Zafeer, M.F., Waseem, M., Chaudhary, S. and Parvez, S. 2012. Cadmium‐induced hepatotoxicity and its abrogation by thymoquinone. Journal of biochemical and molecular toxicology, 26(5):199-205.