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مقاله
1 - Characterization of bioactive compounds from <i>Ficus vallis-choudae</i> Delile (Moraceae)Jean Jules Kezetas Bankeu Amadou Dawé Marius Mbiantcha Guy Raymond Feuya Iftikhar Ali Marthe Aimée Tchuente Tchuenmogne Lateef Mehreen Bruno Lenta Muhammad Ali Augustin Silvère NgouelaTrends in Phytochemical Research , شماره 4 , سال 1 , پاییز 2017Ficus vallis-choudae Delile has been reported to exhibit antifungal, anticonvulsant, anti-inflammatory and antinociceptive activities. Herein we report the first ever pharmacochemical studies on the figs of Ficus vallis-choudae resulting in isolation of a new ceramide n چکیده کاملFicus vallis-choudae Delile has been reported to exhibit antifungal, anticonvulsant, anti-inflammatory and antinociceptive activities. Herein we report the first ever pharmacochemical studies on the figs of Ficus vallis-choudae resulting in isolation of a new ceramide named nkwenamide (1). Also, seven known compounds including the binary mixture of β-amyrin palmitate (2) and lupeol palmitate (3), olean-12-en-3-one (4), n-hexacosan-1-ol (5), β-sitosterol (6), and mixture of β-amyrin (7) and lupeol (8) were isolated. Their structures were elucidated using spectroscopic methods. The methanol extract of the figs of this plant exhibited urease, and α-glucosidase activities and showed DPPH radical scavenging potency with IC50 values, 61.7, 73.7 and 87.4 µg/mL, respectively. It also showed a weak chemiluminescence activity as compared to ibuprofen. The mixture of 2 and 3 exhibited maximum urease inhibitory activity with IC50 value 23.9 µg/mL while the mixture of 7 and 8 showed the maximum α-glucosidase inhibition with IC50 value 44.0 µg/mL. All the isolates showed weak chemiluminescence activity. پرونده مقاله -
مقاله
2 - Constituents of the ripe fruits of <i>Nauclea latifolia</i> Sm. (Rubiaceae) and their antileishmanial activitiesArgan Kelly Nkwenti Wonkam Cyrille Armel Ngansop Njanpa Joël E.T. Ateba Yannick S.F. Fongang Angelbert Awantu J.J.K. Bankeu Jean Rodolph Chouna Fabrice F. Boyom Norbert Sewald Bruno LentaTrends in Phytochemical Research , شماره 4 , سال 6 , پاییز 2022The MeOH extract of the ripe fruits of Nauclea latifolia Sm. (Rubiaceae) showed potent antileishmanial activity in vitro during preliminary screening (IC50 = 2.20 µg/mL) against Leishmania donovani 1S (MHOM/SD/62/1S) promastigotes. Three of the four fractions of t چکیده کاملThe MeOH extract of the ripe fruits of Nauclea latifolia Sm. (Rubiaceae) showed potent antileishmanial activity in vitro during preliminary screening (IC50 = 2.20 µg/mL) against Leishmania donovani 1S (MHOM/SD/62/1S) promastigotes. Three of the four fractions of this extract showed moderate to good activities (7.06 ≤ IC50 ≤ 91.21 µg/mL) on the same strain. The purification of the fractions through CC yielded fifteen compounds whose structures were established based on their MS and NMR data. All the isolated compounds were assessed for their antileishmanial activity against L. donovani and for their cytotoxicity towards Raw 264.7 macrophage cells. 2,6-Dimethoxybenzoquinone (1) and hederagenin (6) showed good antileishmanial activity with IC50 values of 9.94 and 19.3 µM, respectively. Compound 1 was not selective, while compound 6 displayed a good selectivity towards raw 264.7 macrophage cells (SI > 7.82). These results indicate that the extract from N. latifolia fruits could be considered as a source of leishmaniacidal agents. پرونده مقاله